Imperial College London
Alternate

DrXavierDidelot

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
//

Contact

 

+44 (0)20 7594 3622x.didelot

 
 
//

Location

 

G30Medical SchoolSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Didelot:2022:10.1101/2022.07.15.500228,
author = {Didelot, X and Helekal, D and Kendall, M and Ribeca, P},
doi = {10.1101/2022.07.15.500228},
title = {Distinguishing imported cases from locally acquired cases within a geographically limited genomic sample of an infectious disease},
url = {http://dx.doi.org/10.1101/2022.07.15.500228},
year = {2022}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>ABSTRACT</jats:title><jats:p>The ability to distinguish imported cases from locally acquired cases has important consequences for the selection of public health control strategies. Genomic data can be useful for this, for example using a phylogeographic analysis in which genomic data from multiple locations is compared to determine likely migration events between locations. However, these methods typically require good samples of genomes from all locations, which is rarely available. Here we propose an alternative approach that only uses genomic data from a location of interest. By comparing each new case with previous cases from the same location we are able to detect imported cases, as they have a different genealogical distribution than that of locally acquired cases. We show that, when variations in the size of the local population are accounted for, our method has good sensitivity and excellent specificity for the detection of imports. We applied our method to data simulated under the structured coalescent model and demonstrate relatively good performance even when the local population has the same size as the external population. Finally, we applied our method to several recent genomic datasets from both bacterial and viral pathogens, and show that it can, in a matter of seconds or minutes, deliver important insights on the number of imports to a geographically limited sample of a pathogen population.</jats:p>
AU  - Didelot,X
AU  - Helekal,D
AU  - Kendall,M
AU  - Ribeca,P
DO  - 10.1101/2022.07.15.500228
PY  - 2022///
TI  - Distinguishing imported cases from locally acquired cases within a geographically limited genomic sample of an infectious disease
UR  - http://dx.doi.org/10.1101/2022.07.15.500228
ER  -
Download