ProfessorXiao-NingXu

Haig NA, Guan Z, Li D, McMichael A, Raetz CRH, Xu X-Net al., 2011, Identification of Self-lipids Presented by CD1c and CD1d Proteins, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 286, Pages: 37692-37701

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• Citations: 30

Zhang Y, Peng Y, Yan H, Xu K, Saito M, Wu H, Chen X, Ranasinghe S, Kuse N, Powell T, Zhao Y, Li W, Zhang X, Feng X, Li N, Leligdowicz A, Xu X, John M, Takiguchi M, McMichael A, Rowland-Jones S, Dong Tet al., 2011, Multilayered Defense in HLA-B51-Associated HIV Viral Control, JOURNAL OF IMMUNOLOGY, Vol: 187, Pages: 684-691, ISSN: 0022-1767

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• Citations: 41

Wu J, Zhong X, Li CK-F, Zhou J-F, Lu M, Huang K-Y, Dong M, Liu Y, Luo F-J, Du N, Chui C, Liu L-Q, Smith NMG, Li B, Shi N-M, Song L-F, Gao Y, Wang D-Y, Wang X, Zhu W-F, Yan Y, Li Z, Chen J-T, McMichael AJ, Yin W-D, Xu X-N, Shu Yet al., 2011, Optimal vaccination strategies for 2009 pandemic H1N1 and seasonal influenza vaccines in humans, VACCINE, Vol: 29, Pages: 1009-1016, ISSN: 0264-410X

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• Citations: 23

Liu W, de Vlas SJ, Tang F, Ma M-J, Wei M-T, Liu L-J, Li Z-D, Zhang L, Xin Z-T, Tong Y-G, Jiang T, Zhang X-A, He C, Li C, Xu X-N, Yang H, Richardus JH, Cao W-Cet al., 2010, Clinical and Immunological Characteristics of Patients with 2009 Pandemic Influenza A (H1N1) Virus Infection after Vaccination, CLINICAL INFECTIOUS DISEASES, Vol: 51, Pages: 1028-1032, ISSN: 1058-4838

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• Citations: 12

Shu Y, Li CK-F, Li Z, Gao R, Liang Q, Zhang Y, Dong L, Zhou J, Dong J, Wang D, Wen L, Wang M, Bai T, Li D, Dong X, Yu H, Yang W, Wang Y, Feng Z, McMichael AJ, Xu X-Net al., 2010, Avian Influenza A(H5N1) Viruses Can Directly Infect and Replicate in Human Gut Tissues, JOURNAL OF INFECTIOUS DISEASES, Vol: 201, Pages: 1173-1177, ISSN: 0022-1899

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• Citations: 29

Freundt EC, Yu L, Goldsmith CS, Welsh S, Cheng A, Yount B, Liu W, Frieman MB, Buchholz UJ, Screaton GR, Lippincott-Schwartz J, Zaki SR, Xu X-N, Baric RS, Subbarao K, Lenardo MJet al., 2010, The Open Reading Frame 3a Protein of Severe Acute Respiratory Syndrome-Associated Coronavirus Promotes Membrane Rearrangement and Cell Death, JOURNAL OF VIROLOGY, Vol: 84, Pages: 1097-1109, ISSN: 0022-538X

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• Citations: 84

Hong H, Gu Y, Zhang H, Simon AK, Chen X, Wu C, Xu X-N, Jiang Set al., 2010, Depletion of CD4+CD25+regulatory T cells enhances natural killer T cell-mediated anti-tumour immunity in a murine mammary breast cancer model, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 159, Pages: 93-99, ISSN: 0009-9104

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• Citations: 27

Li CK-F, Xu X, 2010, Host Immune Responses to SARS Coronavirus in Humans, MOLECULAR BIOLOGY OF THE SARS-CORONAVIRUS, Editors: Lal, Publisher: SPRINGER, Pages: 259-278, ISBN: 978-3-642-03682-8

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• Citations: 15

Zhang P, Li D, Stewart-Jones G, Shao X, Zhang Y, Chen Q, Li Y, He Y-W, Xu X-N, Zhang H-Tet al., 2009, A single amino acid defines cross-species reactivity of tree shrew (<i>Tupaia belangeri</i>) CD1d to human invariant natural killer T (iNKT) cells, IMMUNOLOGY, Vol: 128, Pages: 500-510, ISSN: 0019-2805

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• Citations: 3

Jia N, Li C, Liu Y-X, Richardus JH, Feng D, Yang H, Dang R-L, Ma Y-H, Xu X-N, Cao W-Cet al., 2009, Lower Cellular Immune Responses to Influenza A (H3N2) in the Elderly, JOURNAL OF MEDICAL VIROLOGY, Vol: 81, Pages: 1471-1476, ISSN: 0146-6615

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• Citations: 7

Freundt EC, Yu L, Park E, Lenardo MJ, Xu X-Net al., 2009, Molecular Determinants for Subcellular Localization of the Severe Acute Respiratory Syndrome Coronavirus Open Reading Frame 3b Protein, JOURNAL OF VIROLOGY, Vol: 83, Pages: 6631-6640, ISSN: 0022-538X

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• Citations: 76

Fan S, Gao Y, Shinya K, Li CK, Li Y, Shi J, Jiang Y, Suo Y, Tong T, Zhong G, Song J, Zhang Y, Tian G, Guan Y, Xu X-N, Bu Z, Kawaoka Y, Chen Het al., 2009, Immunogenicity and protective efficacy of a live attenuated H5N1 vaccine in nonhuman primates, PLoS Pathogens, Vol: 5, ISSN: 1553-7366

The continued spread of highly pathogenic H5N1 influenza viruses among poultry and wild birds, together with the emergence of drug-resistant variants and the possibility of human-to-human transmission, has spurred attempts to develop an effective vaccine. Inactivated subvirion or whole-virion H5N1 vaccines have shown promising immunogenicity in clinical trials, but their ability to elicit protective immunity in unprimed human populations remains unknown. A cold-adapted, live attenuated vaccine with the hemagglutinin (HA) and neuraminidase (NA) genes of an H5N1 virus A/VN/1203/2004 (clade 1) was protective against the pulmonary replication of homologous and heterologous wild-type H5N1 viruses in mice and ferrets. In this study, we used reverse genetics to produce a cold-adapted, live attenuated H5N1 vaccine (AH/AAca) that contains HA and NA genes from a recent H5N1 isolate, A/Anhui/2/05 virus (AH/05) (clade 2.3), and the backbone of the cold-adapted influenza H2N2 A/AnnArbor/6/60 virus (AAca). AH/AAca was attenuated in chickens, mice, and monkeys, and it induced robust neutralizing antibody responses as well as HA-specific CD4+ T cell immune responses in rhesus macaques immunized twice intranasally. Importantly, the vaccinated macaques were fully protected from challenge with either the homologous AH/05 virus or a heterologous H5N1 virus, A/bar-headed goose/Qinghai/3/05 (BHG/05; clade 2.2). These results demonstrate for the first time that a cold-adapted H5N1 vaccine can elicit protective immunity against highly pathogenic H5N1 virus infection in a nonhuman primate model and provide a compelling argument for further testing of double immunization with live attenuated H5N1 vaccines in human trials.

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Zhang H, Hong H, Li D, Ma S, Di Y, Stoten A, Haig N, Di Gleria K, Yu Z, Xu X-N, McMichael A, Jiang Set al., 2009, Comparing Pooled Peptides with Intact Protein for Accessing Cross-presentation Pathways for Protective CD8<SUP>+</SUP> and CD4<SUP>+</SUP> T Cells, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 284, Pages: 9184-9191

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• Citations: 65

Bangs SC, Baban D, Cattan HJ, Li CK-F, McMichael AJ, Xu X-Net al., 2009, Human CD4<SUP>+</SUP> Memory T Cells Are Preferential Targets for Bystander Activation and Apoptosis, JOURNAL OF IMMUNOLOGY, Vol: 182, Pages: 1962-1971, ISSN: 0022-1767

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• Citations: 38

Li D, Wang L, Yu L, Freundt EC, Jin B, Screaton GR, Xu XNet al., 2009, Ig-like transcript 4 inhibits lipid antigen presentation through direct CD1d interaction, Journal of Immunology, Vol: 2, Pages: 1033-1040

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Dharmapatni AASSK, Smith MD, Findlay DM, Holding CA, Evdokiou A, Ahern MJ, Weedon H, Chen P, Screaton G, Xu XN, Haynes DRet al., 2009, Elevated expression of caspase-3 inhibitors, survivin and xIAP correlates with low levels of apoptosis in active rheumatoid synovium, ARTHRITIS RESEARCH & THERAPY, Vol: 11, ISSN: 1478-6354

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• Citations: 52

Dong T, Zhang Y, Xu K, Yan H, James I, Peng Y, Blais M, Gaudieri S, Chen X, Lun W, Wu H, Qu W, Zhao C, Li N, Mao Y, Rostron T, Mallal S, Xu X, McMichael A, John M, Rowland-Jones Set al., 2009, Extensive HLA-driven viral diversity following a single-source HIV-1 outbreak in rural China, RETROVIROLOGY, Vol: 6, ISSN: 1742-4690

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Yang H, Yan H, Li W, Zhang X, Fischer W, Zhang H, Wu H, Korber BT, McMichael AJ, Xu X, Goonetilleke Net al., 2009, A greater breadth of HIV-1-specific T cell responses detected using mosaic peptides compare to consensus peptides, RETROVIROLOGY, Vol: 6, ISSN: 1742-4690

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Dejnirattisai W, Duangchinda T, Lin C-LS, Vasanawathana S, Jones M, Jacobs M, Malasit P, Xu X-N, Screaton G, Mongkolsapaya Jet al., 2008, A Complex Interplay among Virus, Dendritic Cells, T Cells, and Cytokines in Dengue Virus Infections, JOURNAL OF IMMUNOLOGY, Vol: 181, Pages: 5865-5874, ISSN: 0022-1767

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• Citations: 69

Li CK-F, Wu H, Yan H, Ma S, Wang L, Zhang M, Tang X, Temperton NJ, Weiss RA, Brenchley JM, Douek DC, Mongkolsapaya J, Tran B-H, Lin C-LS, Screaton GR, Hou J-L, McMichael AJ, Xu X-Net al., 2008, T cell responses to whole SARS coronavirus in humans, JOURNAL OF IMMUNOLOGY, Vol: 181, Pages: 5490-5500, ISSN: 0022-1767

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• Citations: 356

Li D, Xu X-N, 2008, NKT cells in HIV-1 infection, CELL RESEARCH, Vol: 18, Pages: 817-822, ISSN: 1001-0602

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• Citations: 35

Chen DLN, McMichael AJ, Screaton GR, Xu X-Net al., 2008, Generation and characterisation of CD1d tetramer produced by a lentiviral expression system, JOURNAL OF IMMUNOLOGICAL METHODS, Vol: 330, Pages: 57-63, ISSN: 0022-1759

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• Citations: 7

Chen Y, Chan VSF, Zheng B, Chan KYK, Xu X, To LYK, Huang FP, Khoo US, Lin CLSet al., 2007, A novel subset of putative stem/progenitor CD34⁺Oct-4⁺ cells is the major target for SARS coronavirus in human lung, Journal of Experimental Medicine, Vol: 204, Pages: 2529-2536, ISSN: 0022-1007

Identification of the nature of severe acute respiratory syndrome (SARS)-infected cells is crucial toward understanding the pathogenesis. Using multicolor colocalization techniques, we previously reported that SARS+ cells in the lung of fatally infected patients expressed the only known functional receptor, angiotensin-converting enzyme 2, and also a binding receptor, liver/lymph node–specific ICAM-3–grabbing non-integrin (CD209L). In this study, we show that SARS-infected cells also express the stem/progenitor cell markers CD34 and Oct-4, and do not express cytokeratin or surfactant. These putative lung stem/progenitor cells can also be identified in some non-SARS individuals and can be infected by SARS-coronavirus ex vivo. Infection of these cells may contribute to the loss of lung repair capacity that leads to respiratory failure as clinically observed.

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Cox JH, McMichael AJ, Screaton GR, Xu X-Net al., 2007, CTLs target Th cells that acquire bystander MHC class I-peptide complex from APCs, JOURNAL OF IMMUNOLOGY, Vol: 179, Pages: 830-836, ISSN: 0022-1767

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• Citations: 21

Drakesmith H, Sweetland E, Li D, Schimanski L, Bastin J, Cowley D, Xu X-N, Townsend Aet al., 2007, Identification of new ligands for the haemochromatosis protein HFE, AMERICAN JOURNAL OF HEMATOLOGY, Vol: 82, Pages: 529-530, ISSN: 0361-8609

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Chen YX, Chan VSF, Zheng B, Chan KYK TO LYF, Xu X, Khoo US, Lin CLet al., 2007, A novel subset of putative stem/progenitor cells are the major target for SARS coronavirus in human lung, J Exp Med 2007

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He L, Ding Y, Zhang Q, Che X, He Y, Shen H, Wang H, Li Z, Zhao L, Geng J, Deng Y, Yang L, Li J, Cai J, Qiu L, Wen K, Xu X, Jiang Set al., 2006, Expression of elevated levels of pro-inflammatory cytokines in SARS-CoV-infected ACE2<SUP>+</SUP> cells in SARS patients:: relation to the acute lung injury and pathogenesis of SARS, JOURNAL OF PATHOLOGY, Vol: 210, Pages: 288-297, ISSN: 0022-3417

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• Citations: 295

Bangs SC, McMichael AJ, Xu X-N, 2006, Bystander T cell activation - implications for HIV infection and other diseases, TRENDS IN IMMUNOLOGY, Vol: 27, Pages: 518-524, ISSN: 1471-4906

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• Citations: 53

Mongkolsapaya J, Duangchinda T, Dejnirattisai W, Vasanawathana S, Avirutnan P, Jairungsri A, Khemnu N, Tangthawornchaikul N, Chotiyarnwong P, Sae-Jang K, Koch M, Jones Y, McMichael A, Xu X, Malasit P, Screaton Get al., 2006, T cell responses in dengue hemorrhagic fever: Are cross-reactive T cells suboptimal?, JOURNAL OF IMMUNOLOGY, Vol: 176, Pages: 3821-3829, ISSN: 0022-1767

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• Citations: 212

Chen N, McCarthy C, Drakesmith H, Li DM, Cerundolo V, McMichael AJ, Screaton GR, Xu XNet al., 2006, HIV-1 down-regulates the expression of CD1d via Nef, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 36, Pages: 278-286, ISSN: 0014-2980

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• Citations: 101