Imperial College London
Alternate

ProfessorXiao-NingXu

Faculty of Medicine, Department of Infectious Disease

Chair in Human Immunology
 
 
 
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Contact

 

+44 (0)20 3315 6558x.xu

 
 
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Assistant

 

Dr Victoria Male +44 (0)20 3315 3000

 
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Location

 

Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Yang:2021:10.1126/sciimmunol.abg1703,
author = {Yang, H and Rei, M and Brackenridge, S and Brenna, E and Sun, H and Abdulhaqq, S and Liu, MKP and Ma, W and Kurupati, P and Xu, X and Cerundolo, V and Jenkins, E and Davis, SJ and Sacha, JB and Frueh, K and Picker, LJ and Borrow, P and Gillespie, GM and McMichael, AJ},
doi = {10.1126/sciimmunol.abg1703},
journal = {Science Immunology},
pages = {1--11},
title = {HLA-E-restricted, Gag-specific CD8(+) T cells can suppress HIV-1 infection, offering vaccine opportunities},
url = {http://dx.doi.org/10.1126/sciimmunol.abg1703},
volume = {6},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Human leukocyte antigen-E (HLA-E) normally presents an HLA class Ia signal peptide to the NKG2A/C-CD94 regulatory receptors on natural killer (NK) cells and T cell subsets. Rhesus macaques immunized with a cytomegalovirus-vectored simian immunodeficiency virus (SIV) vaccine generated Mamu-E (HLA-E homolog)–restricted T cell responses that mediated post-challenge SIV replication arrest in >50% of animals. However, HIV-1–specific, HLA-E–restricted T cells have not been observed in HIV-1–infected individuals. Here, HLA-E–restricted, HIV-1–specific CD8+ T cells were primed in vitro. These T cell clones and allogeneic CD8+ T cells transduced with their T cell receptors suppressed HIV-1 replication in CD4+ T cells in vitro. Vaccine induction of efficacious HLA-E–restricted HIV-1–specific T cells should therefore be possible.
AU  - Yang,H
AU  - Rei,M
AU  - Brackenridge,S
AU  - Brenna,E
AU  - Sun,H
AU  - Abdulhaqq,S
AU  - Liu,MKP
AU  - Ma,W
AU  - Kurupati,P
AU  - Xu,X
AU  - Cerundolo,V
AU  - Jenkins,E
AU  - Davis,SJ
AU  - Sacha,JB
AU  - Frueh,K
AU  - Picker,LJ
AU  - Borrow,P
AU  - Gillespie,GM
AU  - McMichael,AJ
DO  - 10.1126/sciimmunol.abg1703
EP  - 11
PY  - 2021///
SN  - 2470-9468
SP  - 1
TI  - HLA-E-restricted, Gag-specific CD8(+) T cells can suppress HIV-1 infection, offering vaccine opportunities
T2  - Science Immunology
UR  - http://dx.doi.org/10.1126/sciimmunol.abg1703
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000634505100012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://immunology.sciencemag.org/content/6/57/eabg1703
VL  - 6
ER  -
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