Imperial College London
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ProfessorXiaodongZhang

Faculty of Medicine, Department of Infectious Disease

Professor of Macromolecular Structure and Function
 
 
 
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Contact

 

+44 (0)20 7594 3151xiaodong.zhang Website

 
 
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Assistant

 

Miss Kelly Butler +44 (0)20 7594 2763

 
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Location

 

104Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Zhang:2021:10.1016/j.semcdb.2020.06.012,
author = {Zhang, X and Carver, A},
doi = {10.1016/j.semcdb.2020.06.012},
journal = {Seminars in Cell and Developmental Biology},
pages = {3--13},
title = {Rad51 filament dynamics and its antagonistic modulators},
url = {http://dx.doi.org/10.1016/j.semcdb.2020.06.012},
volume = {113},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Rad51 recombinase is the central player in homologous recombination, the faithful repair pathway for double-strand breaks and key event during meiosis. Rad51 forms nucleoprotein filaments on single-stranded DNA, exposed by a double-strand break. These filaments are responsible for homology search and strand invasion, which lead to homology-directed repair. Due to its central roles in DNA repair and genome stability, Rad51 is modulated by multiple factors and post-translational modifications. In this review, we summarize our current understanding of the dynamics of Rad51 filaments, the roles of other factors and their modes of action in modulating key stages of Rad51 filaments: formation, stability and disassembly.
AU  - Zhang,X
AU  - Carver,A
DO  - 10.1016/j.semcdb.2020.06.012
EP  - 13
PY  - 2021///
SN  - 1084-9521
SP  - 3
TI  - Rad51 filament dynamics and its antagonistic modulators
T2  - Seminars in Cell and Developmental Biology
UR  - http://dx.doi.org/10.1016/j.semcdb.2020.06.012
UR  - https://www.sciencedirect.com/science/article/pii/S1084952119300990?via%3Dihub
UR  - http://hdl.handle.net/10044/1/81069
VL  - 113
ER  -
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