Imperial College London
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DrYuvalElani

Faculty of Engineering, Department of Chemical Engineering

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 1208y.elani Website CV

 
 
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Location

 

413ACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Zhang:2021:10.1038/s41467-021-21832-x,
author = {Zhang, S and Contini, C and Hindley, J and Bolognesi, G and Elani, Y and Ces, O},
doi = {10.1038/s41467-021-21832-x},
journal = {Nature Communications},
pages = {1--11},
title = {Engineering motile aqueous phase-separated droplets via liposome stabilisation},
url = {http://dx.doi.org/10.1038/s41467-021-21832-x},
volume = {12},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - There are increasing efforts to engineer functional compartments that mimic cellular behaviours from the bottom-up. One behaviour that is receiving particular attention is motility, due to its biotechnological potential and ubiquity in living systems. Many existing platforms make use of the Marangoni effect to achieve motion in water/oil (w/o) droplet systems. However, most of these systems are unsuitable for biological applications due to biocompatibility issues caused by the presence of oil phases. Here we report a biocompatible all aqueous (w/w) PEG/dextran Pickering-like emulsion system consisting of liposome-stabilised cell-sized droplets, where the stability can be easily tuned by adjusting liposome composition and concentration. We demonstrate that the compartments are capable of negative chemotaxis: these droplets can respond to a PEG/dextran polymer gradient through directional motion down to the gradient. The biocompatibility, motility and partitioning abilities of this droplet system offers new directions to pursue research in motion-related biological processes.
AU  - Zhang,S
AU  - Contini,C
AU  - Hindley,J
AU  - Bolognesi,G
AU  - Elani,Y
AU  - Ces,O
DO  - 10.1038/s41467-021-21832-x
EP  - 11
PY  - 2021///
SN  - 2041-1723
SP  - 1
TI  - Engineering motile aqueous phase-separated droplets via liposome stabilisation
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-021-21832-x
UR  - https://www.nature.com/articles/s41467-021-21832-x
UR  - http://hdl.handle.net/10044/1/87424
VL  - 12
ER  -
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