Imperial College London
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DrYuvalElani

Faculty of Engineering, Department of Chemical Engineering

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 1208y.elani Website CV

 
 
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Location

 

413ACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ip:2021:10.1002/cbic.202100072,
author = {Ip, T and Li, Q and Brooks, N and Elani, Y},
doi = {10.1002/cbic.202100072},
journal = {ChemBioChem: a European journal of chemical biology},
pages = {2275--2281},
title = {Manufacture of multilayered artificial cell membranes through sequential bilayer deposition on emulsion templates.},
url = {http://dx.doi.org/10.1002/cbic.202100072},
volume = {22},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Efforts to manufacture artificial cells that replicate the architectures, processes and behaviours of biological cells are rapidly increasing. Perhaps the most commonly reconstructed cellular structure is the membrane, through the use of unilamellar vesicles as models. However, many cellular membranes, including bacterial double membranes, nuclear envelopes, and organelle membranes, are multilamellar. Due to a lack of technologies available for their controlled construction, multilayered membranes are not part of the repertoire of cell-mimetic motifs used in bottom-up synthetic biology. To address this, we developed emulsion-based technologies that allow cell-sized multilayered vesicles to be produced layer-by-layer, with compositional control over each layer, thus enabling studies that would otherwise remain inaccessible. We discovered that bending rigidities scale with the number of layers and demonstrate inter-bilayer registration between coexisting liquid-liquid domains. These technologies will contribute to the exploitation of multilayered membrane structures, paving the way for incorporating protein complexes that span multiple bilayers.
AU  - Ip,T
AU  - Li,Q
AU  - Brooks,N
AU  - Elani,Y
DO  - 10.1002/cbic.202100072
EP  - 2281
PY  - 2021///
SN  - 1439-4227
SP  - 2275
TI  - Manufacture of multilayered artificial cell membranes through sequential bilayer deposition on emulsion templates.
T2  - ChemBioChem: a European journal of chemical biology
UR  - http://dx.doi.org/10.1002/cbic.202100072
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33617681
UR  - https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202100072
UR  - http://hdl.handle.net/10044/1/93283
VL  - 22
ER  -
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