Imperial College London


Faculty of Natural SciencesDepartment of Chemistry








Molecular Sciences Research HubWhite City Campus





Publication Type

3 results found

Jin Y, Vadukul D, Gialama D, Ge Y, Thrush R, White J, Aprile Fet al., 2021, The diagnostic potential of amyloidogenic proteins, International Journal of Molecular Sciences, Vol: 22, ISSN: 1422-0067

Neurodegenerative disorders are a highly prevalent class of diseases, whose pathological mechanisms start before the appearance of any clear symptoms. This fact has prompted scientists to search for biomarkers that could aid early treatment. These currently incurable pathologies share the presence of aberrant aggregates called amyloids in the nervous system, which are composed of specific proteins. In this review, we discuss how these proteins, their conformations and modifications could be exploited as biomarkers for diagnostic purposes. We focus on proteins that are associated with the most prevalent neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases, amyotrophic lateral sclerosis, and frontotemporal dementia. We also describe current challenges in detection, the most recent techniques with diagnostic potentials and possible future developments in diagnosis.

Journal article

Su H, Jin Y, Noroozifar M, Kerman Ket al., 2019, Electrochemical Detection of Isoform‐Specific Interaction between Apolipoprotein E and Amyloid‐β, ChemElectroChem, Vol: 6, Pages: 834-840, ISSN: 2196-0216

Journal article

Su H, Li S, Jin Y, Xian Z, Yang D, Zhou W, Mangaran F, Leung F, Sithamparanathan G, Kerman Ket al., 2017, Nanomaterial-based biosensors for biological detections, Advanced Health Care Technologies, Vol: Volume 3, Pages: 19-29

Journal article

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