Youming Zhang is an Asmarley Lecturer in Respiratory Genomics and the Head of Functional Genomics Group of Genomic Medicine Section in National Heart and Lung Institute at Imperial College London.
Dr Zhang was trained as a physician from Tong Ji Medical University, China. He had further clinical and research training and obtained a Master degree in Medicine from Peking Union Medical College. He then worked as a Clinical Research Fellow in Paediatrics at Beijing Children’s Hospital. He was awarded K.C Wong scholarship and ORS from the University of Oxford that allowed him to study a DPhil at Oxford Wellcome Trust Centre for Human Genetics. His doctoral work was on mapping quantitative traits loci (QTL) of asthma in mice (Zhang Y, et al., Hum Mol Genet 1999). After completing his DPhil study in 1999, Dr Zhang began to work on the positional cloning of the asthma locus on human chromosome 13, and eventually cloned PHF11/SETDB2 genes as asthma suspected genes (Zhang Y. et al., Nature Genetics 2003). In 2006, Dr Zhang was appointed as a Research Council UK Fellow at Imperial College London. This fellowship allowed him the autonomy to develop his work on asthma genetics in mice and human. Consequently he established a conditional knockout mouse program to dissect the newly identified asthma gene ORMDL3. He also established two mutagenesis mouse lines of PHF11 and DPP10. In addition, he also led to establish the cell model to investigate the global gene regulation during immunoglobulin class switch recombination in human B cells.
Dr Zhang focuses his work on the function of the novel genes in respiratory diseases. Recently, the group defined the function roles of polymorphisms of asthma novel genes (Holt RJ, et al., JACI 2011, Zhang Y et al., Mammalian Genome, 2014, Holt RJ, et al., Genes and Immunity, 2015). The group applies state-of-art genomics approaches such as siRNA, gene overexpression, global gene expression profiling, RNA sequencing, ChIP sequencing and metabolite screening to dissect the pathways of the novel genes in disease path-physiology.
Dr Zhang also actively collaborates with physicians and scientists nationally and internationally. At Imperial College, he collaborates with Dr Charlotte Dean, Dr Liming Ying, Professors William Cookson, Professor Miriam Moffatt and Professor Clare Lloyd to dissect the functional roles of PHF11, SETDB2, DPP10 and ORMDL3 (Loeser S, et al., JACI 2016, Zhang Y, et al., Disease Models & Mechanisms 2017. Zhang Y, et al., Am J Respir Crit Care Med 2018). He collaborates with Dr David Fear at King’s College London to identify the regulation genes in Immunoglobulin class switching (Zhang Y, et al., Scientific Reports, 2016).
Dr Zhang is an investigator of MRC & Asthma UK Centre in Allergic Mechanisms of Asthma. He is a visiting professor for Shenzhen Medical School, Shenzhen University, PR China and Xiangyan Hospital, Zhongnan University, Hunan, PR China.
Dr Zhang is a member of editorial board of a few international genetic journals. He also has a passion to present his research work in society and he was a high school tutor for the Researchers in Residence scheme in the UK.
et al., 2018, A retrospective investigation of HLA-B*5801 in hyperuricemia patients in a Han population of China, Pharmacogenetics and Genomics, Vol:28, ISSN:1744-6872, Pages:117-124
et al., 2018, Manipulation of Dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma, Disease Models & Mechanisms, Vol:11, ISSN:1754-8403
et al., 2017, Applications of single-cell sequencing for human lung cancer: the progress and the future perspective, Aims Biophysics, Vol:4, ISSN:2377-9098, Pages:210-221
et al., 2016, Global gene regulation during activation of immunoglobulin class switching in human B cells, Scientific Reports, Vol:6, ISSN:2045-2322
et al., 2016, Pulmonary ORMDL3 is critical for induction of Alternaria induced allergic airways disease, Journal of Allergy and Clinical Immunology, Vol:139, ISSN:1097-6825, Pages:1496-1507.e3
Zhang Y, 2018, Gene expression during the activation of human B cells, Gene Expression and Regulation in Mammalian Cells - Transcription From General Aspects, Editor(s): Uchiumi, Rijeka, Croatia, InTechOpen, ISBN:978-953-51-3856-3