Imperial College London
Alternate

DrYoumingZhang

Faculty of Medicine, National Heart & Lung Institute

Lecturer (non-clinical) in Respiratory Genomics
 
 
 
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Contact

 

+44 (0)20 7594 7974y.zhang

 
 
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Location

 

413Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Zuo:2019:10.1186/s12902-019-0419-7,
author = {Zuo, X and Liu, X and Chen, C and Ou, H and Zhang, Y and Yan, D},
doi = {10.1186/s12902-019-0419-7},
journal = {BMC Endocrine Disorders},
title = {An in-depth analysis of glycosylated haemoglobin level, body mass index and left ventricular diastolic dysfunction in patients with type 2 diabetes},
url = {http://dx.doi.org/10.1186/s12902-019-0419-7},
volume = {19},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Glycosylated hemoglobin (HbA1c) has a detrimental impact on the myocardium with left ventricular (LV) diastolic dysfunction. Obesity is a risk factor of type 2 diabetes.  To understand the relationships between HbA1c, body mass index (BMI) and LV diastolic dysfunction, we performed this interaction analysis in patients with type 2 diabetes.        Methods: Total 925 type 2 diabetes patients were selected from the patients who were diagnosed and treated at the First Affiliated Hospital of Shenzhen University. Patients’ BMI levels were defined as normal (BMI < 24kg/m2) and overweight /obese (BMI ≥ 24kg/m2). Patients’ HbA1c levels were grouped as HbA1c ≥ 9%7% ≤ HbA1c < 9% and HbA1c < 7%. Logistic regression, stratified, interaction analyses, multivariate Cox regression and curve fitting analysis were performed to investigate the correlations and interactions between HbA1c and BMI with LV diastolic dysfunction. Results: The BMI levels were significantly associated with LV diastolic dysfunction in the patients with type 2 diabetes [adjusted model: 1.12 (1.05, 1.20), P = 0.001]. While HbA1c levels had association with LV diastolic dysfunction only in normal BMI group patients [adjusted model: 1.14 (1.01, 1.30), P = 0.0394] and curve correlation was observed. There was a significant interaction between BMI and HbA1c to affect LV diastolic dysfunction (P = 0.0335). Cox regression model analysis showed that the risk of LV diastolic dysfunction was a U type correlation with HbA1c levels in the normal weight group with turning point was HbA1c at 10%. HbA1c level was not found to have a significant association with LV diastolic dysfunction in overweight/obese group.  Conclusions: In patients with type 2 diabetes, correlation between LV diastolic dysfunction and HbA1c was interactively affected by BMI. Glycemic control is beneficial to the heart function in normal body weight patients. For overweight/obese patients, the risk of LV diast
AU  - Zuo,X
AU  - Liu,X
AU  - Chen,C
AU  - Ou,H
AU  - Zhang,Y
AU  - Yan,D
DO  - 10.1186/s12902-019-0419-7
PY  - 2019///
SN  - 1472-6823
TI  - An in-depth analysis of glycosylated haemoglobin level, body mass index and left ventricular diastolic dysfunction in patients with type 2 diabetes
T2  - BMC Endocrine Disorders
UR  - http://dx.doi.org/10.1186/s12902-019-0419-7
UR  - http://hdl.handle.net/10044/1/72965
VL  - 19
ER  -
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