Imperial College London
Alternate

DrYoumingZhang

Faculty of Medicine, National Heart & Lung Institute

Lecturer (non-clinical) in Respiratory Genomics
 
 
 
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Contact

 

+44 (0)20 7594 7974y.zhang

 
 
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Location

 

413Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Li:2011:10.1186/1471-2350-12-103,
author = {Li, F and Jiang, L and Willis-Owen, SA and Zhang, Y and Gao, J},
doi = {10.1186/1471-2350-12-103},
journal = {BMC Medical Genetics},
title = {Vitamin D binding protein variants associate with asthma susceptibility in the Chinese han population},
url = {http://dx.doi.org/10.1186/1471-2350-12-103},
volume = {12},
year = {2011}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Asthma is a genetically heterogeneous disease. Polymorphisms of genes encoding components ofthe vitamin D pathway have been reported to associate with the risk of asthma. We have previously demonstratedthat vitamin D status was associated with lung function in Chinese asthma patients. In this study, we testedwhether polymorphisms of genes encoding for vitamin D receptor (VDR), vitamin D 25-hydroxylase (CYP2R1) andvitamin D binding protein (GC) were associated with asthma in the Chinese Han population.Methods: We sequenced all 8 exons of VDR and all 5 exons of CYP2R1 in a Chinese case-control cohort of asthmaconsisting of 467 cases and 288 unrelated healthy controls. Two mutations were identified in these regions. Thesevariants were specified as rs2228570 in exon 2 of VDR and rs12794714 in exon 1 of CYP2R1. We also genotypedtwo common polymorphisms in GC gene (rs4588 and rs7041) by a PCR-restriction fragment length polymorphism(RFLP) method. We analyzed the association between these 4 polymorphisms and asthma susceptibility andasthma-related traits.Results: Polymorphic markers in VDR and CYP2R1 were not associated with asthma in the Chinese Han cohort.Importantly, variants in GC gene, which give rise to the two most common electrophoretic isoforms of the vitaminD binding protein, were associated with asthma susceptibility. Compared with isoform Gc1, Gc2 was significantlyassociated with the risk of asthma (OR = 1.35, 95% CI = 1.01-1.78 p = 0.006).Conclusions: The results provide supporting evidence for association between GC variants and asthmasusceptibility in the Chinese Han population.
AU  - Li,F
AU  - Jiang,L
AU  - Willis-Owen,SA
AU  - Zhang,Y
AU  - Gao,J
DO  - 10.1186/1471-2350-12-103
PY  - 2011///
SN  - 1471-2350
TI  - Vitamin D binding protein variants associate with asthma susceptibility in the Chinese han population
T2  - BMC Medical Genetics
UR  - http://dx.doi.org/10.1186/1471-2350-12-103
UR  - http://hdl.handle.net/10044/1/28407
VL  - 12
ER  -
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