Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Lecturer (non-clinical) in Respiratory Genomics



+44 (0)20 7594 7974y.zhang




413Guy Scadding BuildingRoyal Brompton Campus





Youming's research focuses on the function roles of novel genes identified by genetic and genomic approaches. His interests include dissecting the function roles of the asthma susceptive genes identified by positional cloning and genome-wide association studies such as PHF11, SETDB2, DPP10, ORMDL3, GSDMB and IL33. Most of the genes express in airway epithelium cells and immune cells in human. He is also interested in mechanisms in immunoglobulin class switch recombination.

The group works on the cellular models, air-liquid interface cultures (ALI) for human airway epithelial cell models, mutagenesis mouse models, gene knockout mouse models and clinical investigations with genomic approaches, metabolites screening, cell molecular biological and pharmacological studies to the interesting genes. The group also applies the newly development of gene editing and single-cell sequencing in human cells. The primary task is to sequence the IgE producing B cells. The group apply fluorescence anisotropy, fluorescence correlation spectroscopy, and  Förster resonance energy transfer (FRET) to detect quantitatively the interactions between ORMDL3 and other proteins in single molecule level. 


Dr Liming Ying, Molecular Medicine, National Heart and Lung Institute,Faculty of MedicineImperial College London, 2017

Prof. Min Zhang, Department of Thorax Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen, PR China

Prof Zhigang Liu, Institute of Allergy and Immunology, Shenzhen University, Shenzhen, PR China

Professor Dewin Yan, Department of Endocrinology,The First Affiliated Hospital of Shenzhen University, PR China

Prof. Jinming Gao, Peking Union Medical College

Professor Clare Lloyd, Leukocyte Biology, NHLI, Imperial College London

Dr Charlotte Dean, Lung Development and Disease Group,NHLI, Imperial College London

Dr David Fear, Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, United Kingdom

Dr Xiaodan Yao, Associate professor of medicine, Research Institute of Nephrology, School of Medicine, Nanjing University, China

Research Student Supervision

Barbolov,M, The role of GSDMB in epithelial inflammation

Chen,R, System biology approach to elucidate the role of microbiome in asthma exacerbations

Fernandes,K, CRISPR/Cas9 to manipulate ORMDL3 gene

Iqbal,S, The ORMDL3 function and oxidative stress in airway epithelial cells

Lau,M-L, The investigation of GSDMB function role in airway epithelial inflammation

Laura,G, Poly I:C stimulation in the knockdown and over expression of ORMDL3 in airway epithelial cells

Loeser,S, Characterisation of the in vivo function of ORMDL3

Noor,G, Investigating function roles of asthma novel gene DPP10 in inflammatory response in airway epithelium cells

Piatek,S, Functional Genomics of IL-33 in Human Epithelial Lung Cells

Vaikousi,E, Gene expression changes in preterm birth

Wang,W, Establishing the method to purify ORMDL3 protein for single molecule study