Imperial College London
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Dr Yen F Tai

Faculty of Medicine, Department of Brain Sciences

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3311 1182yen.tai

 
 
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Location

 

Department of NeurologyCharing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Maxan:2018:10.1002/ana.25354,
author = {Maxan, A and Mason, S and Saint-Pierre, M and Smith, E and Ho, A and Harrower, T and Watts, C and Tai, Y and Pavese, N and Savage, JC and Tremblay, M-È and Gould, P and Rosser, AE and Dunnett, SB and Piccini, P and Barker, RA and Cicchetti, F},
doi = {10.1002/ana.25354},
journal = {Annals of Neurology},
pages = {950--956},
title = {Outcome of cell suspension allografts in a patient with Huntington's disease},
url = {http://dx.doi.org/10.1002/ana.25354},
volume = {84},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - For patients with incurable neurodegenerative disorders such as Huntington's (HD) and Parkinson's disease, cell transplantation has been explored as a potential treatment option. Here, we present the first clinicopathological study of a patient with HD in receipt of cell-suspension striatal allografts who took part in the NEST-UK multicenter clinical transplantation trial. Using various immunohistochemical techniques, we found a discrepancy in the survival of grafted projection neurons with respect to grafted interneurons as well as major ongoing inflammatory and immune responses to the grafted tissue with evidence of mutant huntingtin aggregates within the transplant area. Our results indicate that grafts can survive more than a decade post-transplantation, but show compromised survival with inflammation and mutant protein being observed within the transplant site. Ann Neurol 2018; 1-7.
AU  - Maxan,A
AU  - Mason,S
AU  - Saint-Pierre,M
AU  - Smith,E
AU  - Ho,A
AU  - Harrower,T
AU  - Watts,C
AU  - Tai,Y
AU  - Pavese,N
AU  - Savage,JC
AU  - Tremblay,M-È
AU  - Gould,P
AU  - Rosser,AE
AU  - Dunnett,SB
AU  - Piccini,P
AU  - Barker,RA
AU  - Cicchetti,F
DO  - 10.1002/ana.25354
EP  - 956
PY  - 2018///
SN  - 0364-5134
SP  - 950
TI  - Outcome of cell suspension allografts in a patient with Huntington's disease
T2  - Annals of Neurology
UR  - http://dx.doi.org/10.1002/ana.25354
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30286516
UR  - http://hdl.handle.net/10044/1/65114
VL  - 84
ER  -
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