Imperial College London
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Dr Yen F Tai

Faculty of Medicine, Department of Brain Sciences

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3311 1182yen.tai

 
 
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Location

 

Department of NeurologyCharing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Mahmud:2022:10.1101/2022.03.25.22272947,
author = {Mahmud, M and Hadi, Z and Prendergast, M and Ciocca, M and Saad, AR and Pondeca, Y and Tai, Y and Scott, G and Seemungal, B},
doi = {10.1101/2022.03.25.22272947},
publisher = {Cold Spring Harbor Laboratory},
title = {The effect of galvanic vestibular stimulation on postural balance in Parkinson’s Disease: A systematic review and meta-analysis},
url = {http://dx.doi.org/10.1101/2022.03.25.22272947},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - People with Parkinson’s disease (PD) experience postural imbalance, leading to considerably increased risk of falls. Galvanic Vestibular Stimulation (GVS) is postulated to modulate postural balance in humans and improve it in PD. This systematic review and meta-analysis investigate the effects of GVS on postural balance in PD. Six separate databases and research registers were searched for cross-over design trials that evaluated the effects of GVS on postural balance in PD. We used standardized mean difference (Hedges’ g) as a measure of effect size in all studies. We screened 223 studies, evaluated 14, of which five qualified for the meta-analysis. Among n = 40 patients in five studies (range n= 5 to 13), using a fixed effects model we found an effect size estimate of g = 0.43 (p < 0.001, 95% CI [0.29,0.57]). However, the test for residual heterogeneity was significant (p < 0.001), thus we used a random effects model and found a pooled effect size estimate of 0.62 (p > 0.05, 95% CI [– 0.17, 1.41], I2 = 96.21%). Egger’s test was not significant and thus trim and funnel plot indicated no bias. To reduce heterogeneity, we performed sensitivity analysis and by removing one outlier study (n = 7 patients), we found an effect size estimate of 0.16 (p < 0.05, 95% CI [0.01, 0.31], I2 = 0%). Our meta-analysis found GVS has a favourable effect on postural balance in PD patients, but due to limited literature and inconsistent methodologies, this favourable effect must be interpreted with caution.
AU  - Mahmud,M
AU  - Hadi,Z
AU  - Prendergast,M
AU  - Ciocca,M
AU  - Saad,AR
AU  - Pondeca,Y
AU  - Tai,Y
AU  - Scott,G
AU  - Seemungal,B
DO  - 10.1101/2022.03.25.22272947
PB  - Cold Spring Harbor Laboratory
PY  - 2022///
TI  - The effect of galvanic vestibular stimulation on postural balance in Parkinson’s Disease: A systematic review and meta-analysis
UR  - http://dx.doi.org/10.1101/2022.03.25.22272947
UR  - https://www.medrxiv.org/content/10.1101/2022.03.25.22272947v1
UR  - http://hdl.handle.net/10044/1/99365
ER  -
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