Application of high resolution NMR, MAS NMR and LC-NMR-MS spectroscopic methods including molecular dynamics to characterise metabolic biofluids, intact tissues and the changes induced by drug toxicity or disease.
Stress and dietary intervention on health.
Host-organisms interations including microbiota and parasites.
Novel NMR methods and applications.
Wang Y; Tang H; Nicholson JK; Hylands PJ; Sampson J; Holmes E; (26/01/2005) "A metabonomic strategy for the detection of the metabolic effects of chamomile (Matricaria recutita L.) ingestion." J Agric Food Chem volume 53 issue 2 pp. 191-6 (issn: 0021-8561)
Wang Y; Holmes E; Nicholson JK; Cloarec O; Chollet J; Tanner M; Singer BH; Utzinger J; (24/08/2004) "Metabonomic investigations in mice infected with Schistosoma mansoni: an approach for biomarker identification." Proc Natl Acad Sci U S A volume 101 issue 34 pp. 12676-81 (issn: 0027-8424)
Wang Y; Tang H; Nicholson JK; Hylands PJ; Sampson J; Whitcombe I; Stewart CG; Caiger S; Oru I; Holmes E; (01/03/2004) "Metabolomic strategy for the classification and quality control of phytomedicine: a case study of chamomile flower (Matricaria recutita L.)." Planta Med volume 70 issue 3 pp. 250-5 (issn: 0032-0943)
Tang H; Wang Y; Nicholson JK; Lindon JC; (15/02/2004) "Use of relaxation-edited one-dimensional and two dimensional nuclear magnetic resonance spectroscopy to improve detection of small metabolites in blood plasma." Anal Biochem volume 325 issue 2 pp. 260-72 (issn: 0003-2697)
Wang Y; Bollard ME; Keun H; Antti H; Beckonert O; Ebbels TM; Lindon JC; Holmes E; Tang H; Nicholson JK; (01/12/2003) "Spectral editing and pattern recognition methods applied to high-resolution magic-angle spinning 1H nuclear magnetic resonance spectroscopy of liver tissues." Anal Biochem volume 323 issue 1 pp. 26-32 (issn: 0003-2697
P.S. Belton, Y.L. Wang, "Structure and Dynamics in L-leucinamide" Journal of Molecular Structure, Vol. 602-603, 71-78. 2002.
B.P. Hills, Y.L. Wang, H.R. Tang, "Molecular dynamics in concentrated sugar solutions and glasses - an NMR field cycling study" Molecular Physics. Vol 99(9), 1679-1687, 2001.
Y.L. Wang, P.S. Belton, H. Bridon, E. Garanger, N. Wellner, M.L. Parker, A. Grant, P. Feillet, T.R. Noel, "Physio-chemical studies of Caroubin: a gluten-like protein" J Agric Food Chem. Vol. 49, 3414-3419, 2001.
C.L. Hedley, T.Y. Bogracheva, Y.L. Wang, T.L. Wang. "Effect of inter- and intra-allelic variation on starch granular structure". In Starch-Advances in Structure and Function, Eds. T. L. Barsby, A. M. Donald, P. J. Frazier, Royal Society of Chemistry, Cambridge, UK, 2001.
T.Y. Bogracheva, Y.L. Wang, C.L. Hedley, "The Effect of Water Content on the Ordered/Disordered Structures in Starches", Biopolymer, Vol. 58(3) 247-259, 2001.
Y.L. Wang, P.S. Belton, "Application of Fast Field Cycling Proton NMR Relaxation Spectroscopy to a Crystalline Solid", Chem. Phys. Lett., Vol. 325, 33-38, 2000.
P.S. Belton, Y.L. Wang, "Fast Field Cycling NMR ¾ Applications to Food", In Adv. Magn. Reson. Food Sci., (Ed. P. S. Belton, G. A. Webb), RSC, Cambridge, 2000.
H.R. Tang, Y.L. Wang & P. S. Belton "13C CPMAS Studies of Plant Cell Wall Materials and Model Systems Using Proton Relaxation Induced Spectral Editing (PRISE) Techniques", Solid State Nucl. Magn. Reson. Vol. 15(4) 239-248, 2000.
Y.L. Wang, P.S. Belton, H.R. Tang, "Proton NMR relaxation studies of solid tyrosine derivatives and their mixtures with L-leucinamide", Solid State NMR, Vol. 14, 19-23, 1999.
P.S. Belton, Y.L. Wang, "Proton NMR relaxation studies of solid L-Leucinamide", Molecular Physics, Vol. 90, 119, 1997.
Y.L. Wang, P.S. Belton, H.R. Tang, N. Wellner, S.C. Davies, D.L. Hughes, "Solid state NMR, IR and x-ray diffraction studies of the structure and motion of L-Leucinamide", J. Chem. Soc. Perkin Trans. II, 899, 1997.
Y.L. Wang, P.S. Belton, H.R. Tang, "Proton NMR relaxation studies of solid L-alaninamide", Chem. Phys. Lett., Vol. 268, 387, 1997.
et al., 2009, Panorganismal Metabolic Response Modeling of an Experimental Echinostoma caproni Infection in the Mouse, Journal of Proteome Research, Vol:8, ISSN:1535-3893, Pages:3899-3911
et al., 2009, Topographical Variation in Murine Intestinal Metabolic Profiles in Relation to Microbiome Speciation and Functional Ecological Activity, Journal of Proteome Research, Vol:8, ISSN:1535-3893, Pages:3464-3474
et al., 2009, Top-Down Systems Biology Modeling of Host Metabotype-Microbiome Associations in Obese Rodents, Journal of Proteome Research, Vol:8, ISSN:1535-3893, Pages:2361-2375
et al., 2009, Metabolic profiling of a Schistosoma mansoni infection in mouse tissues using magic angle spinning-nuclear magnetic resonance spectroscopy, International Journal for Parasitology, Vol:39, ISSN:0020-7519, Pages:547-558
et al., 2009, Panorganismal Gut Microbiome-Host Metabolic Crosstalk, Journal of Proteome Research, Vol:8, ISSN:1535-3893, Pages:2090-2105