Imperial College London


Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Visiting Professor





MDPSir Alexander Fleming BuildingSouth Kensington Campus





Research Interest

Application of high resolution NMR, MAS NMR and LC-NMR-MS spectroscopic methods including molecular dynamics to characterise metabolic biofluids, intact tissues and the changes induced by drug toxicity or disease.

Stress and dietary intervention on health.

Host-organisms interations including microbiota and parasites.

Novel NMR methods and applications. 

Recent publications

Wang Y; Tang H; Nicholson JK; Hylands PJ; Sampson J; Holmes E; (26/01/2005)  "A metabonomic strategy for the detection of the metabolic effects of chamomile (Matricaria recutita L.) ingestion." J Agric Food Chem  volume 53  issue 2  pp. 191-6  (issn: 0021-8561) 

Wang Y; Holmes E; Nicholson JK; Cloarec O; Chollet J; Tanner M; Singer BH; Utzinger J; (24/08/2004)  "Metabonomic investigations in mice infected with Schistosoma mansoni: an approach for biomarker identification." Proc Natl Acad Sci U S A  volume 101  issue 34  pp. 12676-81  (issn: 0027-8424) 

Wang Y; Tang H; Nicholson JK; Hylands PJ; Sampson J; Whitcombe I; Stewart CG; Caiger S; Oru I; Holmes E; (01/03/2004)  "Metabolomic strategy for the classification and quality control of phytomedicine: a case study of chamomile flower (Matricaria recutita L.)." Planta Med  volume 70  issue 3  pp. 250-5  (issn: 0032-0943) 

Tang H; Wang Y; Nicholson JK; Lindon JC; (15/02/2004)  "Use of relaxation-edited one-dimensional and two dimensional nuclear magnetic resonance spectroscopy to improve detection of small metabolites in blood plasma." Anal Biochem  volume 325  issue 2  pp. 260-72  (issn: 0003-2697)

Wang Y; Bollard ME; Keun H; Antti H; Beckonert O; Ebbels TM; Lindon JC; Holmes E; Tang H; Nicholson JK; (01/12/2003)  "Spectral editing and pattern recognition methods applied to high-resolution magic-angle spinning 1H nuclear magnetic resonance spectroscopy of liver tissues." Anal Biochem  volume 323  issue 1  pp. 26-32  (issn: 0003-2697

P.S. Belton, Y.L. Wang, "Structure and Dynamics in L-leucinamide" Journal of Molecular Structure, Vol. 602-603, 71-78. 2002.

B.P. Hills, Y.L. Wang, H.R. Tang, "Molecular dynamics in concentrated sugar solutions and glasses - an NMR field cycling study" Molecular Physics. Vol 99(9), 1679-1687, 2001.

Y.L. Wang, P.S. Belton, H. Bridon, E. Garanger, N. Wellner, M.L. Parker, A. Grant, P. Feillet, T.R. Noel, "Physio-chemical studies of Caroubin: a gluten-like protein" J Agric Food Chem. Vol. 49, 3414-3419, 2001.

C.L. Hedley, T.Y. Bogracheva, Y.L. Wang, T.L. Wang. "Effect of inter- and intra-allelic variation on starch granular structure". In Starch-Advances in Structure and Function, Eds. T. L. Barsby, A. M. Donald, P. J. Frazier, Royal Society of Chemistry, Cambridge, UK, 2001.

T.Y. Bogracheva, Y.L. Wang, C.L. Hedley, "The Effect of Water Content on the Ordered/Disordered Structures in Starches", Biopolymer, Vol. 58(3) 247-259, 2001.

Y.L. Wang, P.S. Belton, "Application of Fast Field Cycling Proton NMR Relaxation Spectroscopy to a Crystalline Solid", Chem. Phys. Lett., Vol. 325, 33-38, 2000.

P.S. Belton, Y.L. Wang, "Fast Field Cycling NMR ¾ Applications to Food", In Adv. Magn. Reson. Food Sci., (Ed. P. S. Belton, G. A. Webb), RSC, Cambridge, 2000.

H.R. Tang, Y.L. Wang & P. S. Belton "13C CPMAS Studies of Plant Cell Wall Materials and Model Systems Using Proton Relaxation Induced Spectral Editing (PRISE) Techniques", Solid State Nucl. Magn. Reson. Vol. 15(4) 239-248, 2000.

Y.L. Wang, P.S. Belton, H.R. Tang, "Proton NMR relaxation studies of solid tyrosine derivatives and their mixtures with L-leucinamide", Solid State NMR, Vol. 14, 19-23, 1999.

P.S. Belton, Y.L. Wang, "Proton NMR relaxation studies of solid L-Leucinamide", Molecular Physics, Vol. 90, 119, 1997.

Y.L. Wang, P.S. Belton, H.R. Tang, N. Wellner, S.C. Davies, D.L. Hughes, "Solid state NMR, IR and x-ray diffraction studies of the structure and motion of L-Leucinamide", J. Chem. Soc. Perkin Trans. II, 899, 1997.

Y.L. Wang, P.S. Belton, H.R. Tang, "Proton NMR relaxation studies of solid L-alaninamide", Chem. Phys. Lett., Vol. 268, 387, 1997.



Saric J, Li JV, Wang Y, et al., 2009, Panorganismal Metabolic Response Modeling of an Experimental <i>Echinostoma caproni</i> Infection in the Mouse, Journal of Proteome Research, Vol:8, ISSN:1535-3893, Pages:3899-3911

Martin F-PJ, Wang Y, Yap IKS, et al., 2009, Topographical Variation in Murine Intestinal Metabolic Profiles in Relation to Microbiome Speciation and Functional Ecological Activity, Journal of Proteome Research, Vol:8, ISSN:1535-3893, Pages:3464-3474

Waldram A, Holmes E, Wang Y, et al., 2009, Top-Down Systems Biology Modeling of Host Metabotype-Microbiome Associations in Obese Rodents, Journal of Proteome Research, Vol:8, ISSN:1535-3893, Pages:2361-2375

Li JV, Holmes E, Saric J, et al., 2009, Metabolic profiling of a <i>Schistosoma mansoni</i> infection in mouse tissues using magic angle spinning-nuclear magnetic resonance spectroscopy, International Journal for Parasitology, Vol:39, ISSN:0020-7519, Pages:547-558

Martin F-PJ, Sprenger N, Yap IKS, et al., 2009, Panorganismal Gut Microbiome-Host Metabolic Crosstalk, Journal of Proteome Research, Vol:8, ISSN:1535-3893, Pages:2090-2105

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