Publications
50 results found
Saric J, Li JV, Wang Y, et al., 2009, Panorganismal Metabolic Response Modeling of an Experimental <i>Echinostoma caproni</i> Infection in the Mouse, JOURNAL OF PROTEOME RESEARCH, Vol: 8, Pages: 3899-3911, ISSN: 1535-3893
- Author Web Link
- Cite
- Citations: 29
Martin F-PJ, Wang Y, Yap IKS, et al., 2009, Topographical Variation in Murine Intestinal Metabolic Profiles in Relation to Microbiome Speciation and Functional Ecological Activity, JOURNAL OF PROTEOME RESEARCH, Vol: 8, Pages: 3464-3474, ISSN: 1535-3893
- Author Web Link
- Cite
- Citations: 53
Waldram A, Holmes E, Wang Y, et al., 2009, Top-Down Systems Biology Modeling of Host Metabotype-Microbiome Associations in Obese Rodents, JOURNAL OF PROTEOME RESEARCH, Vol: 8, Pages: 2361-2375, ISSN: 1535-3893
- Author Web Link
- Cite
- Citations: 194
Li JV, Holmes E, Saric J, et al., 2009, Metabolic profiling of a <i>Schistosoma mansoni</i> infection in mouse tissues using magic angle spinning-nuclear magnetic resonance spectroscopy, INTERNATIONAL JOURNAL FOR PARASITOLOGY, Vol: 39, Pages: 547-558, ISSN: 0020-7519
- Author Web Link
- Cite
- Citations: 49
Martin F-PJ, Sprenger N, Yap IKS, et al., 2009, Panorganismal Gut Microbiome-Host Metabolic Crosstalk, JOURNAL OF PROTEOME RESEARCH, Vol: 8, Pages: 2090-2105, ISSN: 1535-3893
- Author Web Link
- Cite
- Citations: 130
Swann J, Wang Y, Abecia L, et al., 2009, Gut microbiome modulates the toxicity of hydrazine: a metabonomic study, MOLECULAR BIOSYSTEMS, Vol: 5, Pages: 351-355, ISSN: 1742-206X
- Author Web Link
- Cite
- Citations: 47
Claus SP, Tsang TM, Wang Y, et al., 2008, Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes, Molecular Systems Biology, Vol: 4
To characterize the impact of gut microbiota on host metabolism, we investigated the multicompartmental metabolic profiles of a conventional mouse strain (C3H/HeJ) (n=5) and its germ-free (GF) equivalent (n=5). We confirm that the microbiome strongly impacts on the metabolism of bile acids through the enterohepatic cycle and gut metabolism (higher levels of phosphocholine and glycine in GF liver and marked higher levels of bile acids in three gut compartments). Furthermore we demonstrate that (1) well-defined metabolic differences exist in all examined compartments between the metabotypes of GF and conventional mice: bacterial co-metabolic products such as hippurate (urine) and 5-aminovalerate (colon epithelium) were found at reduced concentrations, whereas raffinose was only detected in GF colonic profiles. (2) The microbiome also influences kidney homeostasis with elevated levels of key cell volume regulators (betaine, choline, myo-inositol and so on) observed in GF kidneys. (3) Gut microbiota modulate metabotype expression at both local (gut) and global (biofluids, kidney, liver) system levels and hence influence the responses to a variety of dietary modulation and drug exposures relevant to personalized health-care investigations.
Huq SM, Oldapo MNJ, Wang Y, et al., 2008, High glucose and low lactate: a metabolic signature of hypertension in human serum?, 13th Annual Meeting of the European-Council-for-Cardiovascular-Research, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 758-759, ISSN: 0194-911X
Li JV, Wang Y, Saric J, et al., 2008, Global metabolic responses of NMRI mice to an experimental <i>Plasmodium berghei</i> infection, JOURNAL OF PROTEOME RESEARCH, Vol: 7, Pages: 3948-3956, ISSN: 1535-3893
- Author Web Link
- Cite
- Citations: 61
Richards SE, Wang Y, Lawler D, et al., 2008, Self modeling curve resolution recovery of temporal metabolite signal modulation in NMR spectroscopic data sets: Application to a life-long caloric restriction study in dogs, ANALYTICAL CHEMISTRY, Vol: 80, Pages: 4876-4885, ISSN: 0003-2700
- Author Web Link
- Cite
- Citations: 22
Martin F-PJ, Wang Y, Sprenger N, et al., 2008, Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model, MOLECULAR SYSTEMS BIOLOGY, Vol: 4, ISSN: 1744-4292
- Author Web Link
- Open Access Link
- Cite
- Citations: 72
Wang Y, Utzinger J, Saric J, et al., 2008, Global metabolic responses of mice to Trypanosoma brucei brucei infection, Proceedings of the National Academy of Sciences USA, Vol: 105, Pages: 6127-6132
Keun HC, Athersuch TJ, Beckonert O, et al., 2008, Heteronuclear <SUP>19</SUP>F-<SUP>1</SUP>H statistical total correlation spectroscopy as a tool in drug metabolism:: Study of flucloxacillin biotransformation, ANALYTICAL CHEMISTRY, Vol: 80, Pages: 1073-1079, ISSN: 0003-2700
- Author Web Link
- Cite
- Citations: 47
Wang Y, Cloarec O, Tang H, et al., 2008, Magic angle spinning NMR and <SUP>1</SUP>H-<SUP>31</SUP>P heteronuclear statistical total correlation spectroscopy of intact human gut biopsies, ANALYTICAL CHEMISTRY, Vol: 80, Pages: 1058-1066, ISSN: 0003-2700
- Author Web Link
- Cite
- Citations: 47
Martin F-PJ, Wang Y, Sprenger N, et al., 2008, Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model, MOLECULAR SYSTEMS BIOLOGY, Vol: 4, ISSN: 1744-4292
- Author Web Link
- Open Access Link
- Cite
- Citations: 323
Yap IKS, Li JV, Saric J, et al., 2008, Metabonomic and microbiological analysis of the dynamic effect of vancomycin-induced gut microbiota modification in the mouse, Journal of Proteome Research, Vol: 7, Pages: 3718-3728
Saric J, Wang Y, Li JV, et al., 2007, Species variation in the fecal metabolome gives insight into differential gastrointestinal function, Journal of Proteome Research, Vol: 7, Pages: 352-360
Wang Y, Holmes E, Comelli EM, et al., 2007, Topographical variation in metabolic signatures of human gastrointestinal biopsies revealed by high-resolution magic-angle spinning <SUP>1</SUP>H NMR spectroscopy, JOURNAL OF PROTEOME RESEARCH, Vol: 6, Pages: 3944-3951, ISSN: 1535-3893
- Author Web Link
- Cite
- Citations: 62
Martin F-PJ, Dumas M-E, Wang Y, et al., 2007, A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model, MOLECULAR SYSTEMS BIOLOGY, Vol: 3, ISSN: 1744-4292
- Author Web Link
- Open Access Link
- Cite
- Citations: 367
Martin F-PJ, Wang Y, Sprenger N, et al., 2007, Effects of probiotic <i>Lactobacillus Paracasei</i> treatment on the host gut tissue metabolic profiles probed <i>via</i> magic-angle-spinning NMR spectroscopy, JOURNAL OF PROTEOME RESEARCH, Vol: 6, Pages: 1471-1481, ISSN: 1535-3893
- Author Web Link
- Cite
- Citations: 74
Singer BH, Utzinger J, Ryff CD, et al., 2007, Exploiting the Potential of Metabonomics in Large Population Studies, handbook of metabonomics and metabolomics, Editors: Lindon, Nicholson, Holmes, Publisher: Elsevier B.V
Wang Y, Lawler D, Larson B, et al., 2007, Metabonomic investigations of aging and caloric restriction in a life-long dog study, JOURNAL OF PROTEOME RESEARCH, Vol: 6, Pages: 1846-1854, ISSN: 1535-3893
- Author Web Link
- Cite
- Citations: 130
Li J, Wang Y, Fenwick A, et al., 2007, A high-performance liquid chromatography and nuclear magnetic resonance spectroscopy-based analysis of commercially available praziquantel tablets, Journal of Pharmaceutical and Biomedical Analysis, Vol: 45, Pages: 263-267
Marchesi JR, Holmes E, Khan F, et al., 2007, Rapid and noninvasive metabonomic characterization of inflammatory bowel disease, JOURNAL OF PROTEOME RESEARCH, Vol: 6, Pages: 546-551, ISSN: 1535-3893
- Author Web Link
- Cite
- Citations: 454
Wang Y, Holmes E, Tang H, et al., 2006, Experimental metabonomic model of dietary variation and stress interactions, JOURNAL OF PROTEOME RESEARCH, Vol: 5, Pages: 1535-1542, ISSN: 1535-3893
- Author Web Link
- Cite
- Citations: 70
Holmes E, Tang H, Wang Y, et al., 2006, The assessment of plant metabolite profiles by NMR-based methodologies, PLANTA MEDICA, Vol: 72, Pages: 771-785, ISSN: 0032-0943
- Author Web Link
- Cite
- Citations: 106
Wang YL, Utzinger J, Xiao SH, et al., 2006, System level metabolic effects of a <i>Schistosoma japonicum</i> infection in the Syrian hamster, MOLECULAR AND BIOCHEMICAL PARASITOLOGY, Vol: 146, Pages: 1-9, ISSN: 0166-6851
- Author Web Link
- Cite
- Citations: 63
Wang YL, Bollard ME, Nicholson JK, et al., 2006, Exploration of the direct metabolic effects of mercury II chloride on the kidney of Sprague-Dawley rats using high-resolution magic angle spinning <SUP>1</SUP>H NMR spectroscopy of intact tissue and pattern recognition, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, Vol: 40, Pages: 375-381, ISSN: 0731-7085
- Author Web Link
- Cite
- Citations: 32
Gelenbe E, Wang Y, 2006, Modelling large scale autonomous systems, The 9th International Conference on Information Fusion, 10-13 July 2006, Florence, Italy
Tang HR, 2006, High resolution NMR spectroscopy in human metabolism and metabonomics, Handbook in Modern Magnetic Resonance, Editors: Webb, Publisher: Kluwer Academic Publishers
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.