Imperial College London
Professor Yulan Wang

ProfessorYulanWang

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

yulan.wang

 
 
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Location

 

MDPSir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

50 results found

Saric J, Li JV, Wang Y, Keiser J, Veselkov K, Dirnhofer S, Yap IKS, Nicholson JK, Holmes E, Utzinger Jet al., 2009, Panorganismal Metabolic Response Modeling of an Experimental Echinostoma caproni Infection in the Mouse, JOURNAL OF PROTEOME RESEARCH, Vol: 8, Pages: 3899-3911, ISSN: 1535-3893

Journal article

Martin F-PJ, Wang Y, Yap IKS, Sprenger N, Lindon JC, Rezzi S, Kochhar S, Holmes E, Nicholson JKet al., 2009, Topographical Variation in Murine Intestinal Metabolic Profiles in Relation to Microbiome Speciation and Functional Ecological Activity, JOURNAL OF PROTEOME RESEARCH, Vol: 8, Pages: 3464-3474, ISSN: 1535-3893

Journal article

Waldram A, Holmes E, Wang Y, Rantalainen M, Wilson ID, Tuohy KM, McCartney AL, Gibson GR, Nicholson JKet al., 2009, Top-Down Systems Biology Modeling of Host Metabotype-Microbiome Associations in Obese Rodents, JOURNAL OF PROTEOME RESEARCH, Vol: 8, Pages: 2361-2375, ISSN: 1535-3893

Journal article

Li JV, Holmes E, Saric J, Keiser J, Dirnhofer S, Utzinger J, Wang Yet al., 2009, Metabolic profiling of a Schistosoma mansoni infection in mouse tissues using magic angle spinning-nuclear magnetic resonance spectroscopy, INTERNATIONAL JOURNAL FOR PARASITOLOGY, Vol: 39, Pages: 547-558, ISSN: 0020-7519

Journal article

Martin F-PJ, Sprenger N, Yap IKS, Wang Y, Bibiloni R, Rochat F, Rezzi S, Cherbut C, Kochhar S, Lindon JC, Holmes E, Nicholson JKet al., 2009, Panorganismal Gut Microbiome-Host Metabolic Crosstalk, JOURNAL OF PROTEOME RESEARCH, Vol: 8, Pages: 2090-2105, ISSN: 1535-3893

Journal article

Swann J, Wang Y, Abecia L, Costabile A, Tuohy K, Gibson G, Roberts D, Sidaway J, Jones H, Wilson ID, Nicholson J, Holmes Eet al., 2009, Gut microbiome modulates the toxicity of hydrazine: a metabonomic study, MOLECULAR BIOSYSTEMS, Vol: 5, Pages: 351-355, ISSN: 1742-206X

Journal article

Huq SM, Oldapo MNJ, Wang Y, Li J, Loo RL, Braund P, Tobin M, Barton P, Samani NJ, Brown MJ, Clayton D, Connell JMC, Dominczak AF, Farrall M, Lathrop M, Webster J, Nicholson J, Caulfield MJ, Holmes E, Munroe PBet al., 2008, High glucose and low lactate: a metabolic signature of hypertension in human serum?, 13th Annual Meeting of the European-Council-for-Cardiovascular-Research, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 758-759, ISSN: 0194-911X

Conference paper

Claus SP, Tsang TM, Wang Y, Cloarec O, Skordi E, Martin FP, Rezzi S, Ross A, Kochhar S, Holmes E, Nicholson JKet al., 2008, Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes, Molecular Systems Biology, Vol: 4

To characterize the impact of gut microbiota on host metabolism, we investigated the multicompartmental metabolic profiles of a conventional mouse strain (C3H/HeJ) (n=5) and its germ-free (GF) equivalent (n=5). We confirm that the microbiome strongly impacts on the metabolism of bile acids through the enterohepatic cycle and gut metabolism (higher levels of phosphocholine and glycine in GF liver and marked higher levels of bile acids in three gut compartments). Furthermore we demonstrate that (1) well-defined metabolic differences exist in all examined compartments between the metabotypes of GF and conventional mice: bacterial co-metabolic products such as hippurate (urine) and 5-aminovalerate (colon epithelium) were found at reduced concentrations, whereas raffinose was only detected in GF colonic profiles. (2) The microbiome also influences kidney homeostasis with elevated levels of key cell volume regulators (betaine, choline, myo-inositol and so on) observed in GF kidneys. (3) Gut microbiota modulate metabotype expression at both local (gut) and global (biofluids, kidney, liver) system levels and hence influence the responses to a variety of dietary modulation and drug exposures relevant to personalized health-care investigations.

Journal article

Li JV, Wang Y, Saric J, Nicholson JK, Dirnhofer S, Singer BH, Tanner M, Wittlin S, Holmes E, Utzinger Jet al., 2008, Global metabolic responses of NMRI mice to an experimental Plasmodium berghei infection, JOURNAL OF PROTEOME RESEARCH, Vol: 7, Pages: 3948-3956, ISSN: 1535-3893

Journal article

Martin F-PJ, Wang Y, Sprenger N, Yap IKS, Rezzi S, Ramadan Z, Pere-Trepat E, Rochat F, Cherbut C, van Bladeren P, Fay LB, Kochhar S, Lindon JC, Holmes E, Nicholson JKet al., 2008, Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model, MOLECULAR SYSTEMS BIOLOGY, Vol: 4, ISSN: 1744-4292

Journal article

Richards SE, Wang Y, Lawler D, Kochhar S, Holmes E, Lindon JC, Nicholson JKet al., 2008, Self modeling curve resolution recovery of temporal metabolite signal modulation in NMR spectroscopic data sets: Application to a life-long caloric restriction study in dogs, ANALYTICAL CHEMISTRY, Vol: 80, Pages: 4876-4885, ISSN: 0003-2700

Journal article

Wang Y, Utzinger J, Saric J, Li JV, Burckhardt J, Dirnhofer S, Nicholson JK, Singer BH, Brun R, Holmes Eet al., 2008, Global metabolic responses of mice to Trypanosoma brucei brucei infection, Proceedings of the National Academy of Sciences USA, Vol: 105, Pages: 6127-6132

Journal article

Keun HC, Athersuch TJ, Beckonert O, Wang Y, Saric J, Shockcor JP, Lindon JC, Wilson ID, Holmes E, Nicholson JKet al., 2008, Heteronuclear F-19-H-1 statistical total correlation spectroscopy as a tool in drug metabolism: Study of flucloxacillin biotransformation, ANALYTICAL CHEMISTRY, Vol: 80, Pages: 1073-1079, ISSN: 0003-2700

Journal article

Wang Y, Cloarec O, Tang H, Lindon JC, Noimes E, Kochhar S, Nicholson JKet al., 2008, Magic angle spinning NMR and H-1-P-31 heteronuclear statistical total correlation spectroscopy of intact human gut biopsies, ANALYTICAL CHEMISTRY, Vol: 80, Pages: 1058-1066, ISSN: 0003-2700

Journal article

Martin F-PJ, Wang Y, Sprenger N, Yap IKS, Lundstedt T, Lek P, Rezzi S, Ramadan Z, van Bladeren P, Fay LB, Kochhar S, Lindon JC, Holmes E, Nicholson JKet al., 2008, Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model, MOLECULAR SYSTEMS BIOLOGY, Vol: 4, ISSN: 1744-4292

Journal article

Yap IKS, Li JV, Saric J, Martin FP, Davies H, Wang Y, Wilson ID, Nicholson JK, Utzinger J, Marchesi JR, Holmes Eet al., 2008, Metabonomic and microbiological analysis of the dynamic effect of vancomycin-induced gut microbiota modification in the mouse, Journal of Proteome Research, Vol: 7, Pages: 3718-3728

Journal article

Saric J, Wang Y, Li JV, Coen M, Utzinger J, Marchesi JR, Keiser J, Veselkov K, Lindon JC, Nicholson JK, Holmes Eet al., 2007, Species variation in the fecal metabolome gives insight into differential gastrointestinal function, Journal of Proteome Research, Vol: 7, Pages: 352-360

Journal article

Wang Y, Holmes E, Comelli EM, Fotopoulos G, Dorta G, Tang H, Rantalainen MJ, Lindon JC, Corthesy-Theulaz IE, Fay LB, Kochhar S, Nicholson JKet al., 2007, Topographical variation in metabolic signatures of human gastrointestinal biopsies revealed by high-resolution magic-angle spinning H-1 NMR spectroscopy, JOURNAL OF PROTEOME RESEARCH, Vol: 6, Pages: 3944-3951, ISSN: 1535-3893

Journal article

Martin F-PJ, Dumas M-E, Wang Y, Legido-Quigley C, Yap IKS, Tang H, Zirah S, Murphy GM, Cloarec O, Lindon JC, Sprenger N, Fay LB, Kochhar S, van Bladeren P, Holmes E, Nicholson JKet al., 2007, A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model, MOLECULAR SYSTEMS BIOLOGY, Vol: 3, ISSN: 1744-4292

Journal article

Marchesi JR, Holmes E, Khan F, Kochhar S, Scanlan P, Shanahan F, Wilson ID, Wang Yet al., 2007, Rapid and noninvasive metabonomic characterization of inflammatory bowel disease, JOURNAL OF PROTEOME RESEARCH, Vol: 6, Pages: 546-551, ISSN: 1535-3893

Journal article

Wang Y, Lawler D, Larson B, Ramadan Z, Kochhar S, Holmes E, Nicholson JKet al., 2007, Metabonomic investigations of aging and caloric restriction in a life-long dog study, JOURNAL OF PROTEOME RESEARCH, Vol: 6, Pages: 1846-1854, ISSN: 1535-3893

Journal article

Martin F-PJ, Wang Y, Sprenger N, Holmes E, Lindon JC, Kochhar S, Nicholson JKet al., 2007, Effects of probiotic Lactobacillus Paracasei treatment on the host gut tissue metabolic profiles probed via magic-angle-spinning NMR spectroscopy, JOURNAL OF PROTEOME RESEARCH, Vol: 6, Pages: 1471-1481, ISSN: 1535-3893

Journal article

Singer BH, Utzinger J, Ryff CD, Wang YLet al., 2007, Exploiting the Potential of Metabonomics in Large Population Studies, handbook of metabonomics and metabolomics, Editors: Lindon, Nicholson, Holmes, Publisher: Elsevier B.V

Book chapter

Li J, Wang Y, Fenwick A, Clayton TA, Lau YY, Legido-Quigley C, Lindon JC, Utzinger J, Holmes Eet al., 2007, A high-performance liquid chromatography and nuclear magnetic resonance spectroscopy-based analysis of commercially available praziquantel tablets, Journal of Pharmaceutical and Biomedical Analysis, Vol: 45, Pages: 263-267

Journal article

Wang Y, Holmes E, Tang H, Lindon JC, Sprenger N, Turini ME, Bergonzelli G, Fay LB, Kochhar S, Nicholson JKet al., 2006, Experimental metabonomic model of dietary variation and stress interactions, JOURNAL OF PROTEOME RESEARCH, Vol: 5, Pages: 1535-1542, ISSN: 1535-3893

Journal article

Holmes E, Tang H, Wang Y, Seger Cet al., 2006, The assessment of plant metabolite profiles by NMR-based methodologies, PLANTA MEDICA, Vol: 72, Pages: 771-785, ISSN: 0032-0943

Journal article

Wang YL, Utzinger J, Xiao SH, Xue J, Nicholson JK, Tanner M, Singer BH, Holmes Eet al., 2006, System level metabolic effects of a Schistosoma japonicum infection in the Syrian hamster, MOLECULAR AND BIOCHEMICAL PARASITOLOGY, Vol: 146, Pages: 1-9, ISSN: 0166-6851

Journal article

Wang YL, Bollard ME, Nicholson JK, Holmes Eet al., 2006, Exploration of the direct metabolic effects of mercury II chloride on the kidney of Sprague-Dawley rats using high-resolution magic angle spinning H-1 NMR spectroscopy of intact tissue and pattern recognition, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, Vol: 40, Pages: 375-381, ISSN: 0731-7085

Journal article

Gelenbe E, Wang Y, 2006, A mathematical approach for mission planning and rehearsal, Conference on Defense Transformation and Network-Centric Systems, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X

Conference paper

Gelenbe E, Wang Y, 2006, Modelling large scale autonomous systems, The 9th International Conference on Information Fusion, 10-13 July 2006, Florence, Italy

Conference paper

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