Publications
297 results found
Gu Z, Su J, Jiao J, et al., 2009, Simulation of micro-behaviors including nucleation, growth, and aggregation in particle system, SCIENCE IN CHINA SERIES B-CHEMISTRY, Vol: 52, Pages: 241-248, ISSN: 1006-9291
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- Citations: 8
Sun N, Torii R, Wood NB, et al., 2009, Computational Modeling of LDL and Albumin Transport in an In Vivo CT Image-Based Human Right Coronary Artery, JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol: 131, ISSN: 0148-0731
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- Citations: 32
Sun N, Leung JH, Wood NB, et al., 2009, Computational analysis of oxygen transport in a patient-specific model of abdominal aortic aneurysm with intraluminal thrombus, BRITISH JOURNAL OF RADIOLOGY, Vol: 82, Pages: S18-S23, ISSN: 0007-1285
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- Citations: 21
Torii R, Keegan J, Wood NB, et al., 2009, The effect of dynamic vessel motion on haemodynamic parameters in the right coronary artery: a combined MR and CFD study, BRITISH JOURNAL OF RADIOLOGY, Vol: 82, Pages: S24-S32, ISSN: 0007-1285
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- Citations: 25
Tan FPP, Torii R, Borghi A, et al., 2009, Fluid-structure interaction analysis of wall stress and flow patterns in a thoracic aortic aneurysm, International Journal of Applied Mechanics, Vol: 1, Pages: 179-199
In this study, fluid-structure interaction (FSI) simulation was carried out to predict wall shear stress (WSS) and blood flow patterns in a thoracic aortic aneurysm (TAA) where haemodynamic stresses on the diseased aortic wall are thought to lead to the growth, progression and rupture of the aneurysm. Based on MR images, a patient-specific TAA model was reconstructed. A newly developed two-equation laminar-turbulent transitional model was employed and realistic velocity and pressure waveforms were used as boundary conditions. Analysis of results include turbulence intensity, wall displacement, WSS, wall tensile stress and comparison of velocity profiles between MRI data, rigid and FSI simulations. Velocity profiles demonstrated that the FSI simulation gave better agreement with the MRI data while results for the time-averaged WSS (TAWSS) and oscillatory shear index (OSI) distributions showed no qualitative differences between the simulations. With the FSI model, the maximum TAWSS value was 13% lower, whereas the turbulence intensity was significantly higher than the rigid model. The FSI simulation also provided results for wall mechanical stress in terms of von Mises stress, allowing regions of high wall stress to be identified.
Liu D, Wood NB, Witt N, et al., 2009, Computational Analysis of Oxygen Transport in the Retinal Arterial Network, CURRENT EYE RESEARCH, Vol: 34, Pages: 945-956, ISSN: 0271-3683
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- Citations: 36
Liu D, Wood NB, Xu XY, et al., 2009, Image-based Blood Flow Simulation in the Retinal Circulation, 4th European Conference of the International Federation for Medical and Biological Engineering (ECIFMBE), Publisher: SPRINGER, Pages: 1963-1966, ISSN: 1680-0737
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- Citations: 1
Jackson MJ, Wood NB, Zhao S, et al., 2009, Low wall shear stress predicts subsequent development of wall hypertrophy in lower limb bypass grafts, Artery Research, Vol: 3, Pages: 32-38, ISSN: 1872-9312
Background: Venous grafts commonly develop myointimal hyperplasia, which can lead to stenoses and, ultimately, with expression of adhesion molecules, lumenal occlusion. The aim of the present study was to investigate whether wall shear stress measured post-operatively would predict subsequent myointimal hypertrophy in lower limb venous bypass grafts. Methods: Magnetic resonance imaging and ultrasound were performed in a cohort of patients following lower limb venous bypass graft surgery for peripheral arterial disease at baseline (1e2 weeks) and at follow-up (9e12 months). Wall shear stress was determined at baseline using computational fluid dynamics techniques and intima-media thickness along the length of the graft was measured by ultrasound at baseline and follow up. Results: Complete follow-up was possible in eight patients, in whom low wall shear stress at baseline predicted high intima-media thickness. The relationship between wall shear stress (WSS) and intima-media thickness (IMT)was curvilinear with IMTincreasing sharply at lower levels ofWSS (IMT >1.0 mm at <0.3 Pa). Conclusions: Low wall shear stress is associated with subsequent increase in myointimal thickness in lower limb venous bypass grafts. This is believed to be the first prospective study in humans to demonstrate the relationship between low wall shear stress and myointimal thickening and indicates a likely causative role for lowwall shear stress in the development ofmyointimal hyperplasia.
Liu D, Wood NB, Xu XY, et al., 2009, 3D Reconstruction of the Retinal Arterial Tree Using Subject-Specific Fundus Images, 1st ECCOMAS Thematic Conference on Computational Vision and Medical Image Processing, Publisher: SPRINGER, Pages: 187-+
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- Citations: 6
Tan FPP, Torii R, Borghi A, et al., 2009, Analysis of flow patterns in a patient-specific thoracic aortic aneurysm model, Publisher: Elsevier, Pages: 680-690
In this study, a newly developed two-equation transitional model was employed for the prediction of blood flow patterns in a thoracic aortic aneurysm (TAA) where the growth and progression are closely linked to low and oscillating wall shear stresses. Laminar–turbulent transition in the dilated vessel can alter the flow structure, shear stress and pressure distribution within the aneurysm. A patient-specific TAA model was reconstructed from magnetic-resonance (MR) images and measured velocity waveform was used as the inflow condition. Laminar flow and a correlation-based transitional version of Menter’s hybrid k /k x Shear Stress Transport (SST Tran) model were implemented in pulsatile simulations from which WSS distribution was obtained throughout a cardiac cycle and velocity profiles were compared with MR measurements. The correlation-based transitional model was found to produce results in closer agreement with the MR data than the laminar flow simulation.
Soloperto G, Keenan N, Sheppard M, et al., 2009, PLAQUE RUPTURE IN THE CAROTID ARTERY: A COMBINED IMAGING, COMPUTATIONAL AND HISTOLOGICAL ANALYSIS, ASME Summer Bioengineering Conference, Publisher: AMER SOC MECHANICAL ENGINEERS, Pages: 1075-1076
Tan FPP, Soloperto G, Bashford S, et al., 2008, Analysis of Flow Disturbance in a Stenosed Carotid Artery Bifurcation Using Two-Equation Transitional and Turbulence Models, Journal of Biomechanical Engineering, Vol: 130, Pages: 061008-1-061-008-12
In this study, newly developed two-equation turbulence models and transitional variants are employed for the prediction of blood flow patterns in a diseased carotid artery where the growth, progression, and structure of the plaque at rupture are closely linked to low and oscillating wall shear stresses. Moreover, the laminar-turbulent transition in the poststenotic zone can alter the separation zone length, wall shear stress, and pressure distribution over the plaque, with potential implications for stresses within the plaque. Following the validation with well established experimental measurements and numerical studies, a magnetic-resonance (MR) image-based model of the carotid bifurcation with 70% stenosis was reconstructed and simulated using realistic patient-specific conditions. Laminar flow, a correlation-based transitional version of Menter's hybrid k-/k- shear stress transport (SST) model and its “scale adaptive simulation” (SAS) variant were implemented in pulsatile simulations from which analyses of velocity profiles, wall shear stress, and turbulence intensity were conducted. In general, the transitional version of SST and its SAS variant are shown to give a better overall agreement than their standard counterparts with experimental data for pulsatile flow in an axisymmetric stenosed tube. For the patient-specific case reported, the wall shear stress analysis showed discernable differences between the laminar flow and SST transitional models but virtually no difference between the SST transitional model and its SAS variant.
Su J, Gu Z, Li Y, et al., 2008, An Adaptive Direct Quadrature Method of Moment for Population Balance Equations, AICHE JOURNAL, Vol: 54, Pages: 2872-2887, ISSN: 0001-1541
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- Citations: 22
Torii R, Wood NB, Hadjiloizou N, et al., 2008, Differences in coronary artery haemodynamics due to changes in flow and vascular geometry after percutaneous coronary intervention, 13th Annual Meeting of the European-Council-for-Cardiovascular-Research, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 762-762, ISSN: 0194-911X
Torii R, Wood NB, Hadjiloizou N, et al., 2008, Differences in coronary artery haemodynamics due to changes in flow and vascular geometry after percutaneous coronary intervention, Annual Scientific Conference of the British-Cardiovascular-Society/British-Society-for-Cardiovascular-Research, Publisher: B M J PUBLISHING GROUP, Pages: A1-A2, ISSN: 1355-6037
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- Citations: 2
Long Q, Merrifield R, Xu XY, et al., 2008, Subject-specific computational simulation of left ventricular flow based on magnetic resonance imaging, PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE, Vol: 222, Pages: 475-485, ISSN: 0954-4119
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- Citations: 43
Downie SP, Raynor SM, Firmin DN, et al., 2008, Effects of elastic compression stockings on wall shear stress in deep and superficial veins of the calf, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 294, Pages: H2112-H2120, ISSN: 0363-6135
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- Citations: 36
Borghi A, Wood NB, Mohiaddin RH, et al., 2008, Fluid-solid interaction simulation of flow and stress pattern in thoracoabdominal aneurysms: A patient-specific study, JOURNAL OF FLUIDS AND STRUCTURES, Vol: 24, Pages: 270-280, ISSN: 0889-9746
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- Citations: 59
Tan FPP, Soloperto G, Wood NB, et al., 2008, Advanced computational models for disturbed and turbulent flow in stenosed human carotid artery bifurcation, IFMBE Proceedings, Vol: 21 IFMBE, Pages: 390-394, ISSN: 1680-0737
In this study, newly developed two-equation transitional and turbulence models are employed for the prediction of blood flow patterns in diseased carotid artery where the growth, progression and structure of plaque at rupture are closely linked to low and oscillating wall shear stresses. Moreover, laminar-turbulent transition in the post-stenotic zone can alter the separation zone length, wall shear stress and pressure distribution over the plaque, with potential implications for stresses within the plaque. A separate validation study was carried out with well established experimental measurements and numerical studies. Laminar flow, Menter's hybrid k-ε/k-ω Shear Stress Transport model and its transitional version were implemented in pulsatile simulations from which analyses of velocity profiles, wall shear stress and turbulence intensity were conducted. It was found that the transitional version of SST gave better overall agreement with experimental data for pulsatile flow in an axisymmetric stenosed tube and this is further highlighted in the patient-specific geometry simulation results. A magnetic-resonance (MR) image based model of the carotid bifurcation with 70% stenosis was reconstructed and simulated using patient-specific boundary conditions. The laminar flow assumption was found to be inadequate when the differences occurred in the wall shear stress analysis of the patient-derived model. © 2008 Springer-Verlag.
Tan E, Lee S, Torii R, et al., 2008, 3D modelling of pelvic floor pressures using mri for evaluating prolapse and obstructed defecation versus asymptomatic controls, 38th Annual Meeting of the International-Continence-Society, Pages: 614-615, ISSN: 0733-2467
Tan E, Lee S, Torii R, et al., 2008, 3d modelling of pelvic floor pressures using MRI for evaluating prolapse and obstructed defecation versus asymptomatic controls, 38th Annual Meeting of the International-Continence-Society, Publisher: WILEY-BLACKWELL, Pages: 614-615, ISSN: 0733-2467
Tan FPP, Soloperto G, Wood NB, et al., 2008, Advanced Computational Models for Disturbed and Turbulent Flow in Stenosed Human Carotid Artery Bifurcation, 4th Kuala Lumpur International Conference on Biomedical Engineering, Publisher: SPRINGER, Pages: 390-+, ISSN: 1680-0737
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- Citations: 4
Liu D, Wood NB, Xu XY, et al., 2008, 3D reconstruction of the retinal arterial tree based on fundus images using a self-calibration approach, 1st ECCOMAS Thematic Conference on Computational Vision and Medical Image Processing, Publisher: TAYLOR & FRANCIS LTD, Pages: 307-+
Su J, Gu Z, Li Y, et al., 2007, Solution of population balance equation using quadrature method of moments with an adjustable factor, CHEMICAL ENGINEERING SCIENCE, Vol: 62, Pages: 5897-5911, ISSN: 0009-2509
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- Citations: 42
Sun N, Wood NB, Hughes AD, et al., 2007, Influence of pulsatile flow on LDL transport in the arterial wall, ANNALS OF BIOMEDICAL ENGINEERING, Vol: 35, Pages: 1782-1790, ISSN: 0090-6964
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- Citations: 30
Augst AD, Ariff B, Thom SAGM, et al., 2007, Analysis of complex flow and the relationship between blood pressure, wall shear stress, and intima-media thickness in the human carotid artery, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 293, Pages: H1031-H1037, ISSN: 0363-6135
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- Citations: 73
Ma CYJ, Kumar R, Xu XY, et al., 2007, A combined fluid dynamics, mass transport and cell growth model for a three-dimensional perfused biorector for tissue engineering of haematopoietic cells, BIOCHEMICAL ENGINEERING JOURNAL, Vol: 35, Pages: 1-11, ISSN: 1369-703X
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- Citations: 34
Downie SP, Firmin DN, Wood NB, et al., 2007, Role of MRI in investigating the effects of elastic compression stockings on the deformation of the superficial and deep veins in the lower leg, JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol: 26, Pages: 80-85, ISSN: 1053-1807
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- Citations: 20
Sun N, Wood NB, Hughes AD, et al., 2007, Effects of transmural pressure and wall shear stress on LDL accumulation in the arterial wall: a numerical study using a multilayered model, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 292, Pages: H3148-H3157, ISSN: 0363-6135
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- Citations: 51
XY Xu, NB Wood, 2007, The proximal carotid arteries – image-based computational modelling, Carotid Disease: The Role of Imaging in Diagnosis and Management, Editors: Gillard, Graves, Hatsukami, Yuan, Cambridge, Publisher: Cambridge University Press, Pages: 313-323, ISBN: 9780521862264
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