Publications
297 results found
Leung J, Wright A, Cheshire N, et al., 2004, Flow patterns and wall shear stresses in patient-specific models of the abdominal aortic aneurysm., Stud Health Technol Inform, Vol: 103, Pages: 235-242, ISSN: 0926-9630
Abdominal Aortic Aneurysms (AAAs) are a major cause of death in Western societies. However, the factors responsible for the growth and ultimate rupture of AAA are not fully understood. Using computation fluid dynamics combined with CT images, the flow patterns and wall shear stress (WSS) in the AAA of a patient were studied. AAA geometry was obtained from images acquired during a routine CT scan, and a realistic abdominal aortic flow waveform was used as an upstream boundary condition. The computational results showed the presence of multiple flow recirculation zones and overall low WSS in the bulge of the aneurysm. This may provide some insight into the growth of thrombus in AAA.
Merrifield R, Long Q, Xu X, et al., 2004, Combined CFD/MRI Analysis of Left Ventricular Flow, MIAR 2003, Pages: 229-236
Glor FP, Ariff B, Hughes AD, et al., 2004, The integration of medical imaging and computational fluid dynamics for measuring wall shear stress in carotid arteries, PROCEEDINGS OF THE 26TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-7, Vol: 26, Pages: 1415-1418, ISSN: 1094-687X
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- Citations: 2
Cheong PL, Bourne M, Griffith TM, et al., 2004, Comparison of in vivo MRI measurements with numerical predictions, Calgary, 2nd IASTED international conference on biomedical engineering, Innsburck, Austria, 16 - 18 February 2004, Publisher: Acta Press, Pages: 78-82
Glor FP, Ariff B, Crowe LA, et al., 2003, Carotid geometry reconstruction: a comparison between MRI and ultrasound, MEDICAL PHYSICS, Vol: 30, Pages: 3251-3261, ISSN: 0094-2405
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- Citations: 24
Long Q, Merrifield R, Yang GZ, et al., 2003, The influence of inflow boundary conditions on intra left ventricle flow predictions, JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol: 125, Pages: 922-927, ISSN: 0148-0731
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- Citations: 46
Ariff B, Zambanini A, Vamadeva S, et al., 2003, Differing effects of candesartan cilexetil and atenolol on carotid artery remodelling and carotid flow in hypertension, 76th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 452-452, ISSN: 0009-7322
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- Citations: 2
Glor F, Ariff B, Xu XY, et al., 2003, Hemodynamic impact of head rotation on carotids, Archives of Physiology and Biochemistry, Vol: 111, ISSN: 1381-3455
Zhao SZ, Papathanasopoulou P, Long Q, et al., 2003, Comparative study of magnetic resonance imaging and image-based computational fluid dynamics for quantification of pulsatile flow in a carotid bifurcation phantom, ANNALS OF BIOMEDICAL ENGINEERING, Vol: 31, Pages: 962-971, ISSN: 0090-6964
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- Citations: 48
Ariff B, O'Neill A, Stanton A, et al., 2003, Candesartan cilexetil & atenolol have different effects on common carotid artery remodelling in hypertension, 13th European Meeting on Hypertension, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S153-S154, ISSN: 0263-6352
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- Citations: 2
Augst AD, Barratt DC, Hughes AD, et al., 2003, Accuracy and reproducibility of CFD predicted wall shear stress using 3D ultrasound images, JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol: 125, Pages: 218-222, ISSN: 0148-0731
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- Citations: 42
Long Q, Merrifield R, Xu X, et al., 2003, Intra-ventricular blood flow simulation with patient specific geometry, 4th International IEEE EMBS Special Topic Conference on Information Technology Applications in Biomedicine
This study demonstrates a subject specific approach for simulating blood flow within a left ventricle (LV) by a combined analysis of computational fluid dynamics (CFD) and magnetic resonance imaging (MRI). Time dependent LV morphology and wall movements are measured by 3D multi-slice MRI. The information is then used to build numerical meshes for CFD simulation which provides detailed 3D LV velocity and pressure distributions in the LV cavity. Issues related to mesh generation and the prescription of valvular boundary conditions are also discussed. The predicted flow patterns are compared to that of the published MR measurements, demonstrating the effectiveness of the proposed approach.
Long Q, Ariff B, Zhao SZ, et al., 2003, Reproducibility study of 3D geometrical reconstruction of the human carotid bifurcation from magnetic resonance images, MAGNETIC RESONANCE IN MEDICINE, Vol: 49, Pages: 665-674, ISSN: 0740-3194
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- Citations: 17
Papathanasopoulou P, Zhao SZ, Köhler U, et al., 2003, MRI measurement of time-resolved wall shear stress vectors in a carotid bifurcation model, and comparison with CFD predictions, 10th Annual Meeting of the International-Society-for-Magnetic-Resonance-in-Medicine, Publisher: JOHN WILEY & SONS INC, Pages: 153-162, ISSN: 1053-1807
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- Citations: 128
Glor FP, Long Q, Hughes AD, et al., 2003, Reproducibility study of magnetic resonance image-based computational fluid dynamics prediction of carotid bifurcation flow, ANNALS OF BIOMEDICAL ENGINEERING, Vol: 31, Pages: 142-151, ISSN: 0090-6964
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- Citations: 70
Ricard F, Brechtelsbauer C, Lawrence C, et al., 2003, Application of electrical resistance tomography technology to pharmaceutical processes, Pages: 701-706
Recent developments in the use of non-intrusive, electrical measurements to interrogate mixing processes in batch vessels have triggered a joint GSK/Imperial College project aimed at assessing the applicability of Electrical Resistance Tomography (ERT) to pharmaceutical process development. A jacketed 3.5 L glass reactor was fitted with 64 platinum sensors arranged on 4 planes and linked to an ITS P2000 data acquisition system. Several vessel/stirrer configurations aimed at mimicking typical plant reactor geometries were investigated in connection with typical process scenarios in the pharmaceutical industry. Variations in local and bulk conductivity measurements were monitored, and the data obtained were compared with spectroscopic on-line monitoring information as well as kinetic and computational fluid dynamics modelling results. Very encouraging results were achieved for model and industrial processes. This approach shows promise for on-line control of process mixing performance as well as efficiency evaluation and optimisation of reactor geometries. This allows us to conclude that ERT is a valuable tool for the development of robust manufacturing processes for Active Pharmaceutical Ingredients.
Augst AD, Barratt DC, Hughes AD, et al., 2003, Various issues relating to computational fluid dynamics simulations of carotid bifurcation flow based on models reconstructed from three-dimensional ultrasound images, PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE, Vol: 217, Pages: 393-403, ISSN: 0954-4119
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- Citations: 21
Glor FP, Ariff B, Augst AD, et al., 2003, 3D ultrasound-based CFD for carotid flow prediction: a reproducibility study, 2nd MIT Conference on Computational Fluid and Solid Mechanics, Publisher: ELSEVIER SCIENCE BV, Pages: 1701-1704
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- Citations: 1
Lee KW, Xu XY, 2002, Modelling of flow and wall behaviour in a mildly stenosed tube, MEDICAL ENGINEERING & PHYSICS, Vol: 24, Pages: 575-586, ISSN: 1350-4533
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- Citations: 81
Augst AD, Barratt DC, Hughes AD, et al., 2002, CFD modeling of carotid bifurcation blood flow using 3D ultrasound, 7th Annual Meeting of the European-Council-for-Blood-Pressure-and-Cardiovascular-Research, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 571-571, ISSN: 0194-911X
Ariff B, O'Neill A, Xu XY, et al., 2002, Divergent effects on cardiac and carotid vascular remodelling in hypertensive subjects treated with candesartan cilexitil & atenolol., 7th Annual Meeting of the European-Council-for-Blood-Pressure-and-Cardiovascular-Research, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 582-582, ISSN: 0194-911X
Glor FP, Long Q, Hughes AD, et al., 2002, MR based CFD cardiovascular modelling: a reproducibility study on carotid blood flow, 7th Annual Meeting of the European-Council-for-Blood-Pressure-and-Cardiovascular-Research, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 582-582, ISSN: 0194-911X
Zhao SZ, Ariff B, Long Q, et al., 2002, Inter-individual variations in wall shear stress and mechanical stress distributions at the carotid artery bifurcation of healthy humans, JOURNAL OF BIOMECHANICS, Vol: 35, Pages: 1367-1377, ISSN: 0021-9290
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- Citations: 95
Ariff B, Stanton A, Barratt D, et al., 2002, Comparison of the effects of antihypertensive treatment with angiotensin II blockade and beta-blockade on carotid wall structure and haemodynamics: protocol and baseline demographics, JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, Vol: 3, Pages: 116-122, ISSN: 1470-3203
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- Citations: 8
Starmans-Kool MJ, Stanton AV, Zhao SZ, et al., 2002, Measurement of hemodynamics in human carotid artery using ultrasound and computational fluid dynamics, JOURNAL OF APPLIED PHYSIOLOGY, Vol: 92, Pages: 957-961, ISSN: 8750-7587
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- Citations: 12
Long Q, Xu XY, Köhler U, et al., 2002, Quantitative comparison of CFD predicted and MRI measured velocity fields in a carotid bifurcation phantom, BIORHEOLOGY, Vol: 39, Pages: 467-474, ISSN: 0006-355X
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- Citations: 21
King E, Xu XY, Hughes AD, et al., 2002, Quantification of the non-planarity of the human carotid bifurcation, BIORHEOLOGY, Vol: 39, Pages: 419-424, ISSN: 0006-355X
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- Citations: 5
Xu XY, Zhao SZ, Ariff B, et al., 2001, CFD and FE stress analysis of the carotid bifurcation based on individual anatomical and flow data acquired using MRI and ultrasound, American Society of Mechanical Engineers, Bioengineering Division (Publication) BED, Vol: 50, Pages: 621-622, ISSN: 1071-6947
The carotid bifurcation based on individual anatomical and flow data acquired using MRI and ultrasound was analyzed by using finite element (FE) stress analysis code. Blood was assumed to be a Newtonian fluid with a constant viscosity. The results suggested that low wall shear stress and high mechanical stress act together to predispose a particular site to atheroma formation.
Köhler U, Marshall I, Robertson MB, et al., 2001, MRI measurement of wall shear stress vectors in bifurcation models and comparison with CFD predictions., J Magn Reson Imaging, Vol: 14, Pages: 563-573, ISSN: 1053-1807
Steady fluid flow was studied in a simple bifurcation model and in a physiologically realistic model of the human carotid bifurcation. Wall shear stress (WSS) vectors were calculated from phase-contrast (PC) magnetic resonance imaging (MRI) measurements of the velocity field. Velocity measurements in the inflow regions were also used as boundary conditions for computational fluid dynamics (CFD) calculations of WSS, which were compared with those derived from MRI alone. In regions of well-behaved flow, MRI and CFD estimates of WSS were in good general agreement. In regions of disturbed flow, for example near the bifurcation, the quality of the MRI measurements was sufficient for reliable calculation of WSS vectors when a sensitive surface coil was used. The combination of MRI and CFD would seem to be a powerful technique for the investigation of flow phenomena.
Long Q, Xu XY, Ramnarine KV, et al., 2001, Numerical investigation of physiologically realistic pulsatile flow through arterial stenosis, JOURNAL OF BIOMECHANICS, Vol: 34, Pages: 1229-1242, ISSN: 0021-9290
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- Citations: 144
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