Imperial College London
Alternate

Professor Xiao Yun Xu

Faculty of Engineering, Department of Chemical Engineering

Professor, Biofluid Mechanics & Director of Graduate School
 
 
 
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Contact

 

yun.xu Website

 
 
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Location

 

407ACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Zhan:2018:10.1016/j.addr.2018.07.013,
author = {Zhan, W and Alamer, M and Xu, XY},
doi = {10.1016/j.addr.2018.07.013},
journal = {Advanced Drug Delivery Reviews},
pages = {81--103},
title = {Computational modelling of drug delivery to solid tumour: Understanding the interplay between chemotherapeutics and biological system for optimised delivery systems},
url = {http://dx.doi.org/10.1016/j.addr.2018.07.013},
volume = {132},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Drug delivery to solid tumour involves multiple physiological, biochemical and biophysical processes taking place across a wide range of length and time scales. The therapeutic efficacy of anticancer drugs is influenced by the complex interplays among the intrinsic properties of tumours, biophysical aspects of drug transport and cellular uptake. Mathematical and computational modelling allows for a well-controlled study on the individual and combined effects of a wide range of parameters on drug transport and therapeutic efficacy, which would not be possible or economically viable through experimental means. A wide spectrum of mathematical models has been developed for the simulation of drug transport and delivery in solid tumours, including PK/PD-based compartmental models, microscopic and macroscopic transport models, and molecular dynamics drug loading and release models. These models have been used as a tool to identify the limiting factors and for optimal design of efficient drug delivery systems. This article gives an overview of the currently available computational models for drug transport in solid tumours, together with their applications to novel drug delivery systems, such as nanoparticle-mediated drug delivery and convection-enhanced delivery.
AU  - Zhan,W
AU  - Alamer,M
AU  - Xu,XY
DO  - 10.1016/j.addr.2018.07.013
EP  - 103
PY  - 2018///
SN  - 0169-409X
SP  - 81
TI  - Computational modelling of drug delivery to solid tumour: Understanding the interplay between chemotherapeutics and biological system for optimised delivery systems
T2  - Advanced Drug Delivery Reviews
UR  - http://dx.doi.org/10.1016/j.addr.2018.07.013
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30059703
UR  - http://hdl.handle.net/10044/1/62926
VL  - 132
ER  -
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