Imperial College London
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DR YUTONG SAMUEL CAI

Faculty of Medicine, School of Public Health

Honorary Research Fellow
 
 
 
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Contact

 

yutong.cai

 
 
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Location

 

155Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chen:2021:10.1186/s12940-020-00684-w,
author = {Chen, Y and Hodgson, S and Gulliver, J and Granell, R and Henderson, AJ and Cai, Y and Hansell, AL},
doi = {10.1186/s12940-020-00684-w},
journal = {Environmental Health},
title = {Trimester effects of source-specific PM10 on birth weight outcomes in the Avon Longitudinal Study of Parents and Children (ALSPAC)},
url = {http://dx.doi.org/10.1186/s12940-020-00684-w},
volume = {1},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundEvidence suggests that exposure to particulate matter with aerodynamic diameter less than 10 μm (PM10) is associated with reduced birth weight, but information is limited on the sources of PM10 and exposure misclassification from assigning exposures to place of residence at birth.MethodsTrimester and source-specific PM10 exposures (PM10 from road source, local non-road source, and total source) in pregnancy were estimated using dispersion models and a full maternal residential history for 12,020 births from the Avon longitudinal study of parents and children (ALSPAC) cohort in 1990–1992 in the Bristol area. Information on birth outcomes were obtained from birth records. Maternal sociodemographic and lifestyle factors were obtained from questionnaires. We used linear regression models for continuous outcomes (birth weight, head circumference (HC), and birth length (BL) and logistic regression models for binary outcomes (preterm birth (PTB), term low birth weight (TLBW) and small for gestational age (SGA)). Sensitivity analysis was performed using multiple imputation for missing covariate data.ResultsAfter adjustment, interquartile range increases in source specific PM10 from traffic were associated with 17 to 18% increased odds of TLBW in all pregnancy periods. We also found odds of TLBW increased by 40% (OR: 1.40, 95%CI: 1.12, 1.75) and odds of SGA increased by 18% (OR: 1.18, 95%CI: 1.05, 1.32) per IQR (6.54 μg/m3) increase of total PM10 exposure in the third trimester.ConclusionThis study adds to evidence that maternal PM10 exposures affect birth weight, with particular concern in relation to exposures to PM10 from road transport sources; results for total PM10 suggest greatest effect in the third trimester. Effect size estimates relate to exposures in the 1990s and are higher than those for recent studies – this may relate to reduced exposure misclassification through use of full residential history information, changes in
AU  - Chen,Y
AU  - Hodgson,S
AU  - Gulliver,J
AU  - Granell,R
AU  - Henderson,AJ
AU  - Cai,Y
AU  - Hansell,AL
DO  - 10.1186/s12940-020-00684-w
PY  - 2021///
SN  - 1476-069X
TI  - Trimester effects of source-specific PM10 on birth weight outcomes in the Avon Longitudinal Study of Parents and Children (ALSPAC)
T2  - Environmental Health
UR  - http://dx.doi.org/10.1186/s12940-020-00684-w
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000608240500002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://ehjournal.biomedcentral.com/articles/10.1186/s12940-020-00684-w#rightslink
UR  - http://hdl.handle.net/10044/1/86185
VL  - 1
ER  -
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