Imperial College London
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DR YUTONG SAMUEL CAI

Faculty of Medicine, School of Public Health

Honorary Research Fellow
 
 
 
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Contact

 

yutong.cai

 
 
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Location

 

155Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Schikowski:2014:10.1183/09031936.00132213,
author = {Schikowski, T and Adam, M and Marcon, A and Cai, Y and Vierkotter, A and Carsin, AE and Jacquemin, B and Al, KZ and Beelen, R and Birk, M and Bridevaux, PO and Brunekeef, B and Burney, P and Cirach, M and Cyrys, J and de, HK and de, MR and de, NA and Declercq, C and Forsberg, B and Hardy, R and Heinrich, J and Hoek, G and Jarvis, D and Keidel, D and Kuh, D and Kuhlbusch, T and Migliore, E and Mosler, G and Nieuwenhuijsen, MJ and Phuleria, H and Rochat, T and Schindler, C and Villani, S and Tsai, MY and Zemp, E and Hansell, A and Kauffmann, F and Sunyer, J and Probst-Hensch, N and Kramer, U and Kunzli, N},
doi = {10.1183/09031936.00132213},
journal = {Eur.Respir.J.},
title = {Association of ambient air pollution with the prevalence and incidence of COPD},
url = {http://dx.doi.org/10.1183/09031936.00132213},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The role of air pollution in chronic obstructive pulmonary disease (COPD) remains uncertain.The aim was to assess the impact of chronic exposure to air pollution on COPD in four cohorts using the standardised ESCAPE exposure estimates. Annual average particulate matter (PM), nitrogen oxides (NOx) and road traffic exposure were assigned to home addresses using land-use regression models. COPD was defined by NHANES reference equation (forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) less than the lower limit of normal) and the Global Initiative for Chronic Obstructive Lung Disease criterion (FEV1/FVC <0.70) and categorised by severity in non-asthmatics.We included 6550 subjects with assigned NOx and 3692 with PM measures. COPD was not associated with NO2 or PM10 in any individual cohort. In meta-analyses only NO2, NOx, PM10 and the traffic indicators were positively, although not significantly, associated with COPD. The only statistically significant associations were seen in females (COPD prevalence using GOLD: OR 1.57, 95% CI 1.11-2.23; and incidence: OR 1.79, 95% CI 1.21-2.68).None of the principal results were statistically significant, the weak positive associations of exposure with COPD and the significant subgroup findings need to be evaluated in further well standardised cohorts followed up for longer time, and with time-matched exposure assignments
AU  - Schikowski,T
AU  - Adam,M
AU  - Marcon,A
AU  - Cai,Y
AU  - Vierkotter,A
AU  - Carsin,AE
AU  - Jacquemin,B
AU  - Al,KZ
AU  - Beelen,R
AU  - Birk,M
AU  - Bridevaux,PO
AU  - Brunekeef,B
AU  - Burney,P
AU  - Cirach,M
AU  - Cyrys,J
AU  - de,HK
AU  - de,MR
AU  - de,NA
AU  - Declercq,C
AU  - Forsberg,B
AU  - Hardy,R
AU  - Heinrich,J
AU  - Hoek,G
AU  - Jarvis,D
AU  - Keidel,D
AU  - Kuh,D
AU  - Kuhlbusch,T
AU  - Migliore,E
AU  - Mosler,G
AU  - Nieuwenhuijsen,MJ
AU  - Phuleria,H
AU  - Rochat,T
AU  - Schindler,C
AU  - Villani,S
AU  - Tsai,MY
AU  - Zemp,E
AU  - Hansell,A
AU  - Kauffmann,F
AU  - Sunyer,J
AU  - Probst-Hensch,N
AU  - Kramer,U
AU  - Kunzli,N
DO  - 10.1183/09031936.00132213
PY  - 2014///
TI  - Association of ambient air pollution with the prevalence and incidence of COPD
T2  - Eur.Respir.J.
UR  - http://dx.doi.org/10.1183/09031936.00132213
UR  - pm:24488569
ER  -
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