Imperial College London
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DR YUTONG SAMUEL CAI

Faculty of Medicine, School of Public Health

Honorary Research Fellow
 
 
 
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Contact

 

yutong.cai

 
 
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Location

 

155Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cai:2014:10.1136/thoraxjnl-2013-204352,
author = {Cai, Y and Schikowski, T and Adam, M and Buschka, A and Carsin, A and Jacquemin, B and Marcon, A and Sanchez, M and Vierkötter, A and Al-Kanaani, Z and Beelen, R and Birk, M and Brunekreef, B and Cirach, M and Clavel-Chapelon, F and Declercq, C and de, Hoogh K and de, Nazelle A and Ducret-Stich, RE and Valeria, Ferretti V and Forsberg, B and Gerbase, MW and Hardy, R and Heinrich, J and Hoek, G and Jarvis, D and Keidel, D and Kuh, D and Nieuwenhuijsen, MJ and Ragettli, MS and Ranzi, A and Rochat, T and Schindler, C and Sugiri, D and Temam, S and Tsai, M and Varraso, R and Kauffmann, F and Krämer, U and Sunyer, J and Künzli, N and Probst-Hensch, N and Hansell, AL},
doi = {10.1136/thoraxjnl-2013-204352},
journal = {Thorax},
pages = {1005--1014},
title = {Cross-sectional associations between air pollution and chronic bronchitis: an ESCAPE meta-analysis across five cohorts},
url = {http://dx.doi.org/10.1136/thoraxjnl-2013-204352},
volume = {69},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background This study aimed to assess associations of outdoor air pollution on prevalence of chronic bronchitis symptoms in adults in five cohort studies (Asthma-E3N, ECRHS, NSHD, SALIA, SAPALDIA) participating in the European Study of Cohorts for Air Pollution Effects (ESCAPE) project.Methods Annual average particulate matter (PM10, PM2.5, PMabsorbance, PMcoarse), NO2, nitrogen oxides (NOx) and road traffic measures modelled from ESCAPE measurement campaigns 2008–2011 were assigned to home address at most recent assessments (1998–2011). Symptoms examined were chronic bronchitis (cough and phlegm for ≥3months of the year for ≥2years), chronic cough (with/without phlegm) and chronic phlegm (with/without cough). Cohort-specific cross-sectional multivariable logistic regression analyses were conducted using common confounder sets (age, sex, smoking, interview season, education), followed by meta-analysis.Results 15279 and 10537 participants respectively were included in the main NO2 and PM analyses at assessments in 1998–2011. Overall, there were no statistically significant associations with any air pollutant or traffic exposure. Sensitivity analyses including in asthmatics only, females only or using back-extrapolated NO2 and PM10 for assessments in 1985–2002 (ECRHS, NSHD, SALIA, SAPALDIA) did not alter conclusions. In never-smokers, all associations were positive, but reached statistical significance only for chronic phlegm with PMcoarse OR 1.31 (1.05 to 1.64) per 5µg/m3 increase and PM10 with similar effect size. Sensitivity analyses of older cohorts showed increased risk of chronic cough with PM2.5abs (black carbon) exposures.Conclusions Results do not show consistent associations between chronic bronchitis symptoms and current traffic-related air pollution in adult European populations.
AU  - Cai,Y
AU  - Schikowski,T
AU  - Adam,M
AU  - Buschka,A
AU  - Carsin,A
AU  - Jacquemin,B
AU  - Marcon,A
AU  - Sanchez,M
AU  - Vierkötter,A
AU  - Al-Kanaani,Z
AU  - Beelen,R
AU  - Birk,M
AU  - Brunekreef,B
AU  - Cirach,M
AU  - Clavel-Chapelon,F
AU  - Declercq,C
AU  - de,Hoogh K
AU  - de,Nazelle A
AU  - Ducret-Stich,RE
AU  - Valeria,Ferretti V
AU  - Forsberg,B
AU  - Gerbase,MW
AU  - Hardy,R
AU  - Heinrich,J
AU  - Hoek,G
AU  - Jarvis,D
AU  - Keidel,D
AU  - Kuh,D
AU  - Nieuwenhuijsen,MJ
AU  - Ragettli,MS
AU  - Ranzi,A
AU  - Rochat,T
AU  - Schindler,C
AU  - Sugiri,D
AU  - Temam,S
AU  - Tsai,M
AU  - Varraso,R
AU  - Kauffmann,F
AU  - Krämer,U
AU  - Sunyer,J
AU  - Künzli,N
AU  - Probst-Hensch,N
AU  - Hansell,AL
DO  - 10.1136/thoraxjnl-2013-204352
EP  - 1014
PY  - 2014///
SN  - 0040-6376
SP  - 1005
TI  - Cross-sectional associations between air pollution and chronic bronchitis: an ESCAPE meta-analysis across five cohorts
T2  - Thorax
UR  - http://dx.doi.org/10.1136/thoraxjnl-2013-204352
UR  - http://hdl.handle.net/10044/1/26732
VL  - 69
ER  -
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