Imperial College London
Portrait Picture

DR YUTONG SAMUEL CAI

Faculty of Medicine, School of Public Health

Honorary Research Fellow
 
 
 
//

Contact

 

yutong.cai

 
 
//

Location

 

155Wright Fleming WingSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Adam:2014:10.1183/09031936.00130014,
author = {Adam, M and Schikowski, T and Carsin, AE and Cai, Y and Jacquemin, B and Sanchez, M and Vierkötter, A and Marcon, A and Keidel, D and Sugiri, D and Al, Kanani Z and Nadif, R and Siroux, V and Hardy, R and Kuh, D and Rochat, T and Bridevaux, P-O and Eeftens, M and Tsai, M-Y and Villani, S and Phuleria, HC and Birk, M and Cyrys, J and Cirach, M and de, Nazelle A and Nieuwenhuijsen, MJ and Forsberg, B and de, Hoogh K and Declerq, C and Bono, R and Piccioni, P and Quass, U and Heinrich, J and Jarvis, D and Pin, I and Beelen, R and Hoek, G and Brunekreef, B and Schindler, C and Sunyer, J and Krämer, U and Kauffmann, F and Hansell, AL and Künzli, N and Probst-Hensch, N},
doi = {10.1183/09031936.00130014},
journal = {European Respiratory Journal},
pages = {38--50},
title = {Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis},
url = {http://dx.doi.org/10.1183/09031936.00130014},
volume = {45},
year = {2014}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The chronic impact of ambient air pollutants on lung function in adults is not fully understood. The objective of this study was to investigate the association of long-term exposure to ambient air pollution with lung function in adult participants from five cohorts in the European Study of Cohorts for Air Pollution Effects (ESCAPE).Residential exposure to nitrogen oxides (NO2, NOx) and particulate matter (PM) was modelled and traffic indicators were assessed in a standardised manner. The spirometric parameters forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) from 7613 subjects were considered as outcomes. Cohort-specific results were combined using meta-analysis.We did not observe an association of air pollution with longitudinal change in lung function, but we observed that a 10 μg·m−3 increase in NO2 exposure was associated with lower levels of FEV1 (−14.0 mL, 95%CI −25.8– −2.1) and FVC (−14.9 mL, 95% CI −28.7– −1.1). An increase of 10 μg·m−3 in PM10, but not other PM metrics (PM2.5, coarse fraction of PM, PM absorbance), was associated with a lower level of FEV1 (−44.6 mL, 95% CI −85.4– −3.8) and FVC (−59.0 mL, 95% CI −112.3– −5.6). The associations were particularly strong in obese persons.This study adds to the evidence for an adverse association of ambient air pollution with lung function in adults at very low levels in Europe.
AU  - Adam,M
AU  - Schikowski,T
AU  - Carsin,AE
AU  - Cai,Y
AU  - Jacquemin,B
AU  - Sanchez,M
AU  - Vierkötter,A
AU  - Marcon,A
AU  - Keidel,D
AU  - Sugiri,D
AU  - Al,Kanani Z
AU  - Nadif,R
AU  - Siroux,V
AU  - Hardy,R
AU  - Kuh,D
AU  - Rochat,T
AU  - Bridevaux,P-O
AU  - Eeftens,M
AU  - Tsai,M-Y
AU  - Villani,S
AU  - Phuleria,HC
AU  - Birk,M
AU  - Cyrys,J
AU  - Cirach,M
AU  - de,Nazelle A
AU  - Nieuwenhuijsen,MJ
AU  - Forsberg,B
AU  - de,Hoogh K
AU  - Declerq,C
AU  - Bono,R
AU  - Piccioni,P
AU  - Quass,U
AU  - Heinrich,J
AU  - Jarvis,D
AU  - Pin,I
AU  - Beelen,R
AU  - Hoek,G
AU  - Brunekreef,B
AU  - Schindler,C
AU  - Sunyer,J
AU  - Krämer,U
AU  - Kauffmann,F
AU  - Hansell,AL
AU  - Künzli,N
AU  - Probst-Hensch,N
DO  - 10.1183/09031936.00130014
EP  - 50
PY  - 2014///
SN  - 1399-3003
SP  - 38
TI  - Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis
T2  - European Respiratory Journal
UR  - http://dx.doi.org/10.1183/09031936.00130014
UR  - http://hdl.handle.net/10044/1/40410
VL  - 45
ER  -
Download