Dr Yuval Elani leads the Soft Microsystems Group as an EPSRC Research Fellow in the Department of Chemistry. In under four years he has been awarded 3 Fellowships totalling c. £700k, and helped secure > £2.5 M of funding. He is an expert in soft-matter, opto- and microfluidics, synthetic biology, and chemical biology. His research centres on constructing soft chemical microsystems that can be interfaced with biology, and on the bottom-up construction of artificial cells that resemble biological cells in form and function.
He investigates how soft microsystems and artificial cells can be interfaced with living biological systems – organelles, cells, and tissues – to yield hybrid cellular bionic systems that are composed of living and synthetic components. In particular, Yuval’s research focusses on:
- How artificial cells can be used as cell mimics to probe basic biological phenomena (in particular membrane-based processes) in a simplified environment
- How artificial cells can be engineered to perform bespoke and biotechnologically useful functions as synthetic soft-matter micromachines in a suite of industrial and clinical applications.
Yuval is co-investigator of the Membrane Biophysics Platform, is co-founder and member of the executive of FABRICELL, and is Associate Editor of Experimental Biology and Medicine. Yuval sits on the management team for the Leverhulme Centre for Cellular Bionics, and has published extensively in the areas of synthetic biology, biointerfaces, and soft-matter biotechnology. His work has been recognised by the UK Parliamentary and Scientific Committee who awarded him the Roscoe Medal and Gold Award, and by the World Economic Forum, who selected him to be part of their Young Scientist Community (50 under 40 worldwide). He is also the recipient of the IC Lord Porter Prize, the Royal Society of Chemistry Rita and John Cornforth Award, and holds a prestigious EPSRC Fellowship to conduct blue skies research.
Yuval sits on the EPSRC Early Career advisory board for Engineering. Please feel free to get in touch if you like to speak about early career matters or would like him to relay any messages to the Research Councils.
Yuval’s academic training was at Cambridge University where he read Natural Sciences as an undergraduate, and at Imperial College London, where he completed a multidisciplinary MRes studying drug/membrane interactions and a PhD on developing microfluidic technologies for the generation of compartmentalised cell-mimetic microreactors. This was followed by a Doctoral Prize Fellowship, completed in 2016.
Spatially segregated vesicle-based artificial cells as chemical microreactors. Nature Communications
There are currently 3 fully-funded 3-year PhD positions available in the group.
- Engineering biointerfaces between synthetic and biological cells
- Cells and organelles as embedded biomodules in artificial cells
- Engineering novel cell mimetic membrane architectures
Please see here for more details. If you are interested in applying, or want more information on eligibility criteria, please contact me directly at email@example.com
If you are a talented and dedicated scientist that is interested in joining the group as an MSci, MRes, UROP, or PhD student, please get in touch.
Prospective PhD students should be aware of the President's PhD Scholarship Scheme, Schrödinger Scholarship Scheme, China Scholarship Council, and Imperial Marshall Scholarship. We have accepted MRes students from research programmes in Chemical Biology, Plant Chemical Biology, and Nanomaterials in the past, but those on other courses who would like to work with us are welcome to get in touch.
et al., 2017, Programming membrane permeability using integrated membrane pores and blockers as molecular regulators, Chemical Communications, Vol:53, ISSN:1359-7345, Pages:12282-12285
Salehi-Reyhani A, Ces O, Elani Y, 2017, Artificial cell mimics as simplified models for the study of cell biology, Experimental Biology and Medicine, Vol:242, ISSN:1535-3702, Pages:1309-1317
Elani Y, 2016, Construction of membrane-bound artificial cells using microfluidics: a new frontier in bottom-up synthetic biology, Biochemical Society Transactions, Vol:44, ISSN:0300-5127, Pages:723-730
et al., 2016, Microfluidic generation of encapsulated droplet interface bilayer networks (multisomes) and their use as cell-like reactors., Chemical Communications, Vol:52, ISSN:1364-548X, Pages:5961-5964
Elani Y, Law RV, Ces O, 2015, Protein synthesis in artificial cells: using compartmentalisation for spatial organisation in vesicle bioreactors, Physical Chemistry Chemical Physics, Vol:17, ISSN:1463-9076, Pages:15534-15537
Elani Y, Law RV, Ces O, 2014, Vesicle-based artificial cells as chemical microreactors with spatially segregated reaction pathways, Nature Communications, Vol:5, ISSN:2041-1723
et al., 2014, A droplet trapping microfluidic device for the study of mass-transport across droplet interface bilayers, Pages:1620-1622