Imperial College London
Alternate

Dr Melody Zhifang Ni

Faculty of Medicine, Department of Surgery & Cancer

Senior Research Fellow
 
 
 
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Contact

 

+44 (0)20 3312 7657z.ni

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Vijayasingam:2020:10.1136/thoraxjnl-2019-214177,
author = {Vijayasingam, A and Frost, E and Wilkins, J and Gillen, L and Premachandra, P and Mclaren, K and Gilmartin, D and Picinali, L and Vidal-Diez, A and Borsci, S and Ni, MZ and Tang, WY and Morris-Rosendahl, D and Harcourt, J and Elston, C and Simmonds, NJ and Shah, A},
doi = {10.1136/thoraxjnl-2019-214177},
journal = {Thorax},
pages = {632--639},
title = {Tablet and web-based audiometry to screen for hearing loss in adults with cystic fibrosis},
url = {http://dx.doi.org/10.1136/thoraxjnl-2019-214177},
volume = {75},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - INTRODUCTION: Individuals with chronic lung disease (eg, cystic fibrosis (CF)) often receive antimicrobial therapy including aminoglycosides resulting in ototoxicity. Extended high-frequency audiometry has increased sensitivity for ototoxicity detection, but diagnostic audiometry in a sound-booth is costly, time-consuming and requires a trained audiologist. This cross-sectional study analysed tablet-based audiometry (Shoebox MD) performed by non-audiologists in an outpatient setting, alongside home web-based audiometry (3D Tune-In) to screen for hearing loss in adults with CF. METHODS: Hearing was analysed in 126 CF adults using validated questionnaires, a web self-hearing test (0.5 to 4 kHz), tablet (0.25 to 12 kHz) and sound-booth audiometry (0.25 to 12 kHz). A threshold of ≥25 dB hearing loss at ≥1 audiometric frequency was considered abnormal. Demographics and mitochondrial DNA sequencing were used to analyse risk factors, and accuracy and usability of hearing tests determined. RESULTS: Prevalence of hearing loss within any frequency band tested was 48%. Multivariate analysis showed age (OR 1.127; (95% CI: 1.07 to 1.18; p value<0.0001) per year older) and total intravenous antibiotic days over 10 years (OR 1.006; (95% CI: 1.002 to 1.010; p value=0.004) per further intravenous day) were significantly associated with increased risk of hearing loss. Tablet audiometry had good usability, was 93% sensitive, 88% specific with 94% negative predictive value to screen for hearing loss compared with web self-test audiometry and questionnaires which had poor sensitivity (17% and 13%, respectively). Intraclass correlation (ICC) of tablet versus sound-booth audiometry showed high correlation (ICC >0.9) at all frequencies ≥4 kHz. CONCLUSIONS: Adults with CF have a high prevalence of drug-related hearing loss and tablet-based audiometry can be a practical, accurate screening tool within integrated ototoxicity monitoring programmes for early detection.
AU  - Vijayasingam,A
AU  - Frost,E
AU  - Wilkins,J
AU  - Gillen,L
AU  - Premachandra,P
AU  - Mclaren,K
AU  - Gilmartin,D
AU  - Picinali,L
AU  - Vidal-Diez,A
AU  - Borsci,S
AU  - Ni,MZ
AU  - Tang,WY
AU  - Morris-Rosendahl,D
AU  - Harcourt,J
AU  - Elston,C
AU  - Simmonds,NJ
AU  - Shah,A
DO  - 10.1136/thoraxjnl-2019-214177
EP  - 639
PY  - 2020///
SN  - 0040-6376
SP  - 632
TI  - Tablet and web-based audiometry to screen for hearing loss in adults with cystic fibrosis
T2  - Thorax
UR  - http://dx.doi.org/10.1136/thoraxjnl-2019-214177
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32409613
UR  - https://thorax.bmj.com/content/early/2020/05/14/thoraxjnl-2019-214177.info
UR  - http://hdl.handle.net/10044/1/80023
VL  - 75
ER  -
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