Publications
228 results found
Macsai E, Takats Z, Derzbach L, et al., 2013, Verification of Skin Autofluorescence Values by Mass Spectrometry in Adolescents with Type 1 Diabetes: Brief Report, DIABETES TECHNOLOGY & THERAPEUTICS, Vol: 15, Pages: 269-272, ISSN: 1520-9156
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- Citations: 8
Strittmatter N, Jones EA, Veselkov KA, et al., 2013, Analysis of intact bacteria using rapid evaporative ionisation mass spectrometry, CHEMICAL COMMUNICATIONS, Vol: 49, Pages: 6188-6190, ISSN: 1359-7345
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- Citations: 52
Denes J, Szabo E, Robinette SL, et al., 2012, Metabonomics of Newborn Screening Dried Blood Spot Samples: A Novel Approach in the Screening and Diagnostics of Inborn Errors of Metabolism, ANALYTICAL CHEMISTRY, Vol: 84, Pages: 10113-10120, ISSN: 0003-2700
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- Citations: 61
Nicholson JK, Holmes E, Kinross JM, et al., 2012, Metabolic phenotyping in clinical and surgical environments, Nature, Vol: 491, Pages: 384-392, ISSN: 0028-0836
Metabolic phenotyping involves the comprehensive analysis of biological fluids or tissue samples. This analysis allows biochemical classification of a person's physiological or pathological states that relate to disease diagnosis or prognosis at the individual level and to disease risk factors at the population level. These approaches are currently being implemented in hospital environments and in regional phenotyping centres worldwide. The ultimate aim of such work is to generate information on patient biology using techniques such as patient stratification to better inform clinicians on factors that will enhance diagnosis or the choice of therapy. There have been many reports of direct applications of metabolic phenotyping in a clinical setting.
Denes J, Robinette S, Hester A, et al., 2012, APPLICATION OF HIGH RESOLUTION MASS SPECTROMETRY IN NEWBORN SCREENING, JOURNAL OF INHERITED METABOLIC DISEASE, Vol: 35, Pages: S6-S6, ISSN: 0141-8955
Muirhead LJ, Kinross J, FitzMaurice TS, et al., 2012, Surgical systems biology and personalized longitudinal phenotyping in critical care, Personalized Medicine, Vol: 9, Pages: 593-608, ISSN: 1741-0541
Systems-wide molecular analysis of the metabolic, inflammatory and immune response to surgical trauma has yet to be translated into the operating room. Surgical patients are exposed to a large number of heterogeneous environmental insults that cannot only be quantified by genome-orientated ‘omics platforms. Furthermore, surgery demands rapid or near real-time analysis. Systems-level metabolic phenotyping provides a novel ‘global’ perspective of an organism’s metabolic response to surgical injury and, therefore, serves as an ideal platform for the development of personalized therapies in surgery. This article reviews current personalized approaches to healthcare in surgery and explores future directions for personalized surgical biomarker discovery and therapeutics. In particular, this article discusses our vision of ‘personalized metabolic phenotyping’ in surgery, and outlines next-generation technologies that will make this approach a reality.
Gerbig S, Golf O, Balog J, et al., 2012, Analysis of colorectal adenocarcinoma tissue by desorption electrospray ionization mass spectrometric imaging, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol: 403, Pages: 2315-2325, ISSN: 1618-2642
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- Citations: 81
Hollenhorst MI, Lips KS, Wolff M, et al., 2012, Luminal cholinergic signalling in airway lining fluid: a novel mechanism for activating chloride secretion via Ca<SUP>2+</SUP>-dependent Cl<SUP>-</SUP> and K<SUP>+</SUP> channels, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 166, Pages: 1388-1402, ISSN: 0007-1188
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- Citations: 21
Tsakiris I, Torocsik D, Gyongyosi A, et al., 2012, Carboxypeptidase-M is regulated by lipids and CSFs in macrophages and dendritic cells and expressed selectively in tissue granulomas and foam cells, LABORATORY INVESTIGATION, Vol: 92, Pages: 345-361, ISSN: 0023-6837
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- Citations: 14
Takats Z, Denes J, Kinross J, 2012, Identifying the margin: a new method to distinguish between cancerous and noncancerous tissue during surgery, Future Oncology, Vol: 8, Pages: 113-116, ISSN: 1479-6694
Telbisz A, Hegedus C, Ozvegy-Laczka C, et al., 2012, Antibody binding shift assay for rapid screening of drug interactions with the human ABCG2 multidrug transporter, EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, Vol: 45, Pages: 101-109, ISSN: 0928-0987
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- Citations: 29
Strittmatter N, Duering R-A, Takats Z, 2012, Analysis of wastewater samples by direct combination of thin-film microextraction and desorption electrospray ionization mass spectrometry, ANALYST, Vol: 137, Pages: 4037-4044, ISSN: 0003-2654
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- Citations: 44
Hinz K-P, Gelhausen E, Schaefer K-C, et al., 2011, Characterization of surgical aerosols by the compact single-particle mass spectrometer LAMPAS 3, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol: 401, Pages: 3165-3172, ISSN: 1618-2642
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- Citations: 9
Guenther S, Schoefer K-C, Balog J, et al., 2011, Electrospray Post-Ionization Mass Spectrometry of Electrosurgical Aerosols, JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Vol: 22, Pages: 2082-2089, ISSN: 1044-0305
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- Citations: 17
Gyarmati B, Szabo E, Szalay B, et al., 2011, Serum maternal hepcidin levels 3 days after delivery are higher compared to those measured at parturition, JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, Vol: 37, Pages: 1620-1624, ISSN: 1341-8076
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- Citations: 13
Schaefer K-C, Balog J, Szaniszlo T, et al., 2011, Real Time Analysis of Brain Tissue by Direct Combination of Ultrasonic Surgical Aspiration and Sonic Spray Mass Spectrometry, ANALYTICAL CHEMISTRY, Vol: 83, Pages: 7729-7735, ISSN: 0003-2700
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- Citations: 79
Roempp A, Guenther S, Takats Z, et al., 2011, Mass spectrometry imaging with high resolution in mass and space (HR<SUP>2</SUP> MSI) for reliable investigation of drug compound distributions on the cellular level, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol: 401, Pages: 65-73, ISSN: 1618-2642
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- Citations: 125
Schaefer K-C, Szaniszlo T, Guenther S, et al., 2011, In Situ, Real-Time Identification of Biological Tissues by Ultraviolet and Infrared Laser Desorption Ionization Mass Spectrometry, ANALYTICAL CHEMISTRY, Vol: 83, Pages: 1632-1640, ISSN: 0003-2700
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- Citations: 74
McHugh DMS, Cameron CA, Abdenur JE, et al., 2011, Clinical validation of cutoff target ranges in newborn screening of metabolic disorders by tandem mass spectrometry: A worldwide collaborative project, GENETICS IN MEDICINE, Vol: 13, Pages: 230-254, ISSN: 1098-3600
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- Citations: 253
Katona M, Denes J, Skoumal R, et al., 2011, Intact skin analysis by desorption electrospray ionization mass spectrometry, ANALYST, Vol: 136, Pages: 835-840, ISSN: 0003-2654
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- Citations: 18
Gyarmati B, Szabó E, Szalay B, et al., 2010, [Increased hepcidin levels three days after gynecological interventions]., Orv Hetil, Vol: 151, Pages: 1790-1794, ISSN: 0030-6002
UNLABELLED: Hepcidin is an endogenous substance that inhibits iron absorption and plasma iron levels. Due to technical reasons its levels are not routinely assessed and data regarding its clinical relevance are limited. We analyzed the alteration of hepcidin levels following gynecological interventions. Hepcidin levels were determined by mass spectrometry, along with the levels of interleukin-6, the main inductor of hepcidin with ELISA in 17 women undergoing gynecological intervention just prior to and three days after the surgery. The results were related to iron homeostasis parameters. A decrease in serum iron (median, interquartile range) (17.85 [15.25-24.9] versus 10.1 [7.6-15.0] μmol/l, p<0.01) and transferrin levels (60.3 [55.93-67.18] versus 53.1 [49.7-60.0], p< 0.01) μmol/l, simultaneously with an increase in hepcidin (2.75 [2.24-3.51] versus 8.01 [6.8-9.67] μg/l, p<0.01) and interleukin-6 levels (ND = not detected) (ND [ND - 2.2] versus 8.15 [2.31-12.86], p<0.01). CONCLUSION: As with other acute phase proteins postoperative hepcidin levels dramatically increase, simultaneously with other changes in iron homeostasis. These results indicate a possible causative relationship between increased hepcidin and decreased iron levels. In clinical practice, determination of hepcidin levels may be indicated for characterization and, possibly, prediction of postoperative iron homeostasis. However, measurement of hepcidin level in clinical practice is unlikely in the near future due to the lack of available kits for routine clinical laboratories.
Toldi G, Stenczer B, Molvarec A, et al., 2010, Hepcidin concentrations and iron homeostasis in preeclampsia, CLINICAL CHEMISTRY AND LABORATORY MEDICINE, Vol: 48, Pages: 1423-1426, ISSN: 1434-6621
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- Citations: 35
Balog J, Szaniszlo T, Schaefer K-C, et al., 2010, Identification of Biological Tissues by Rapid Evaporative Ionization Mass Spectrometry, ANALYTICAL CHEMISTRY, Vol: 82, Pages: 7343-7350, ISSN: 0003-2700
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- Citations: 160
Gerbig S, Takats Z, 2010, Analysis of triglycerides in food items by desorption electrospray ionization mass spectrometry, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, Vol: 24, Pages: 2186-2192, ISSN: 0951-4198
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- Citations: 46
Roempp A, Guenther S, Schober Y, et al., 2010, Histology by Mass Spectrometry: Label-Free Tissue Characterization Obtained from High-Accuracy Bioanalytical Imaging, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 49, Pages: 3834-3838, ISSN: 1433-7851
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- Citations: 165
Katona M, Kiss K, Angyal V, et al., 2009, A mass spectrometry based functional assay for the quantitative assessment of ABC transporter activity, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, Vol: 23, Pages: 3372-3376, ISSN: 0951-4198
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- Citations: 5
Hegedus C, Oezvegy-Laczka C, Apati A, et al., 2009, Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti-cancer effects and pharmacological properties, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 158, Pages: 1153-1164, ISSN: 0007-1188
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- Citations: 176
Denes J, Katona M, Hosszu A, et al., 2009, Analysis of Biological Fluids by Direct Combination of Solid Phase Extraction and Desorption Electrospray Ionization Mass Spectrometry, ANALYTICAL CHEMISTRY, Vol: 81, Pages: 1669-1675, ISSN: 0003-2700
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- Citations: 47
Czuczy N, Katona M, Takats Z, 2009, Selective detection of specific protein-ligand complexes by electrosonic spray-precursor ion scan tandem mass spectrometry., J Am Soc Mass Spectrom, Vol: 20, Pages: 227-237, ISSN: 1044-0305
A novel mass spectrometric method for the selective detection of specific protein-ligand complexes is presented. The new method is based on electrosonic spray ionization of samples containing protein and ligand molecules, and mass spectrometric detection using the precursor ion scanning function on a triple quadrupole instrument. Mass-selected intact protein-ligand complex ions are subjected to fragmentation by means of collision-induced dissociation in the collision cell of the instrument, while the second mass analyzer is set to the m/z of protonated ligand ions or their alkali metal adducts. The method allows for the detection of only those ions which yield ions characteristic of the ligand molecules upon fragmentation. Since the scan range of first analyzer is set well above the m/z of the ligand ion, and the CID conditions are established to permit fragmentation of only loosely bound, noncovalent complexes, the method is specific to the detection of protein-ligand complexes under described conditions. Behavior of biologically specific and nonspecific complexes was compared under various instrumental settings. Parameters were optimized to obtain maximal selectivity for specific complexes. Specific and nonspecific complexes were found to show markedly different fragmentation characteristics, which can be a basis for selective detection of complexes with biological relevance. Preparation of specific and nonspecific complexes containing identical building blocks was attempted. Complex ions with identical stoichiometry but different origin showed the expected difference in fragmentation characteristics, which gives direct evidence for the different mechanism of specific versus nonspecific complex ion formation.
Schaefer K-C, Denes J, Albrecht K, et al., 2009, In Vivo, In Situ Tissue Analysis Using Rapid Evaporative Ionization Mass Spectrometry, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 48, Pages: 8240-8242, ISSN: 1433-7851
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- Citations: 219
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