Evidence of Restoration of both pancreatic β-Cell and α-Cell Function in Type 2 Diabetes
Zhili Wang*1, Mohammad A Ghatei2, Nima Khandan-Nia2, Haiyan Xiong1, Qianyi Tang1, Fang Li1, Tu Ya Sa Ren1, Rui Yun1, Yu Song Dai1, Li Jie Geng1, Mozong Tang1, Li Zhao1, Hongmei Miao1 and Yanxia Wang1
1Beijing ChaoYang Diabetes Hospital, Beijing, China, 2Imperial College, London, United Kingdom
Poster Presentation American Endocrine Society, San Francisco, 2013
Z.L.Wang, Renming Wang, Ali A. Owji, David M. Smith, Mohammad A. Ghatei and Stephen R. Bloom
Glucagon-like peptide-1 is a physiological incretin in rat.
The Journal of Clinical Investigation 1995; 95:417-421.
Z.L.Wang, Bennet W.M., Wang R. M., Ghatei M.A., and S.R. Bloom
Evidence of a paracrine role of neuropeptide Y in the regulation of insulin release from pancreatic islets of normal and dexamethasone treated rats.
Endocrinology 1994: 135: 200-206.
Z.L.Wang, Bennet W.M., Ghatei M.A., Byfield P.G., Smith D.M., S.R. Bloom
Influence of islet amyloid polypeptide and the 8-37 fragment of islet amyloid polypeptide on insulin release from perifused rat islets.
Diabetes 1992; 42:330-335.
Gar Lo, Steve Legon, Carol Austin, Simon Wallis, Zhili Wang, and S.R. Bloom
Characterization of complementary DNA encoding the rat neuromedin U precursor.
Molecular Endocrinology 1992; 6(10) 1538-1544.
Rohit N. Kulkarni, Zhili Wang, Karen O. Akinsanya, William M. Bennet, Ren-Ming Wang, David M. Smith, Mohammad A. Ghatei, Peter Byfield, and S.R. Bloom
Pyroglutamyl-phenylalanine-proline amide attenuates TRH-stimulated insulin secretion in perifused rat islets and insulin-secreting clonal β-cell lines.
K.O. Akinsanya, A.J. Griffiths, Z.L. Wang, D. Wynick and S.R. Bloom
Paracrine control of the islet and pituitary-A model system for regulatory peptides.
In Gastrointestinal tract and endocrine system P95-112.
Edited by M.V. Singer and R. Ziegler. Dordrecht/Boston/London. 1994
Z.L. Wang, Renming Wang, Ali A. Owji, David M. Smith, Mohammad A. Ghatei, and S.R. Bloom
The role of GLP-1 (7-36) in control of insulin secretion investigated using the receptor antagonist, exendin(9-39).
Clinical Science 1995; 89 (Supply) 33:2P-M5.
(Oral presentation in the European Society of Clinical Investigation and the British Medical Research Society 1995 Meeting) 2.4.1995 Cambridge, UK.
Z.L. Wang, Rohit N. Kulkarni, Bennet W.M., Renming Wang, David M. Smith, Mohammad A. Ghatei, and Stephen R. Bloom
Evidence for the presence of a galanin-like hormone within pancreatic islets.
Diabetes 1995;44(Supply 1) 249 A: 917.
Renming Wang, Z.L. Wang, Ali A. Owji, David M. Smith, Mohammad A. Ghatei, and S.R. Bloom
Endogenous GLP-1 (7-36) amide in the regulation of insulin and glucagon secretion.
Diabetes 1995; 44 (Supply 1) 86A:323.
Z.L. Wang, Bennet W.M, Ghatei M.A., Bloom S.R
Evidence that islet amyloid polypeptide regulates insulin secretion by an intra-islet paracrine action.
Diabetic Medicine 1992; 9; (Supply) 2:S13; A10.
(Oral presentation at the British Diabetes Association Medical & Scientific Meeting 3rd – 4th September 1992. UK).
Z.L. Wang, Bennet W.M., R.M.Wang, Nandha K.A., Ghatei M.A., Bloom S.R.
Glucose-stimulated neuropeptide Y secretion from pancreatic islets is 7-fold increased by prior dexamethaone treatment.
Clinical Science 1993; 84 (Supply) 34P:123.
Z.L. Wang, Bennet W.M., Ghatei M.A., Bloom S.R.
Inhibition by islet amyloid polypeptide of insulin release from isolated perifused rat islets.
Regulatory peptides 1992; 39 (Supply) 249.
Bennet W.M., Z.L. Wang, Bloom S.R.,
Islet expression of the powerful paracrine regulator, neuropeptide Y, is 14-fold elevated by dexamethasone, insulin obliterates this change.
Diabetic Medicine 1992; 9 (Supply) S27: P19.
L. Zhao, Z.L. Wang, M.A. Ghatei, J.M.B. Hughes, and R.J.D. Winter
Increased cardiac synthesis and secretion of brain natriuretic peptide during hypoxic pulmonary remodelling in rats.
The European respiratory Journal 1993; 6: (Supply 17) 191s, P 350.
Bennet W.M., Z.L. Wang, Bretherton-Watt D., Ghatei M.A., and Bloom S.R.
Dexamethasone effects on rat islet calcitonin Gene-related peptide.
J Endocrinology 1991; 131 (Supply); 25:62.
W.M. Bennet, Z.L. Wang, J.N.P. Wilding, S.G. Gilbey, M.A. Ghatei and S.R. Bloom
Unaltered islet regulatory peptides in the islets of rats with dietary-induced obesity.
Regulatory peptides 1991; 35:22:225 (Supply).
W.M. Bennet, Z.L. Wang, J. Byrne, S. Hearn, M.A. Ghatei and S.R. Bloom
Increased vasoactive intestinal polypeptide in islets from obese zucker rats.
Diabetelogia 1991; 34 (Supply 2):A77:305.
Bennet W.M., Z.L. Wang, Bretherton-Watt D., Khandan-Nia N., Ghatei M.A., and Bloom S.R.
Elevated regulatory peptides in the islet during fasting.
Diabetic Medicine 1991; 8(Supply 1):10A-A36.
H. Jamal, K.A. Nandha, M.A. Ghatei, Z.L. Wang, and S.R. Bloom
Peptides in isolated rat islets of Langerhans: lack of effect of mifepristone (Ru486). A novel antiglucocorticoid.
Regulatory peptides 1992; 39:2-3;249 (Supply).
R.M. Wang, Z.L. Wang, Bennet W.M., Ghatei M.A., S.R. Bloom
NPY release from perifused rat islet of normal and dexamethasone treated rat is differentially modulated by glucose.
European Journal of Endocrinology 1994; 130 (Supply 2) P2.058.
W.M. Bennet, Z.L. Wang, P.M. Jones, R.M. Wang, R.F. James, N.J. London, M.A. Ghatei, and S.R. Bloom
Presence of Neuropeptide Y and its messenger ribonucleic acid in human islets; -evidence for a possible paracrine role.
Journal of Clinical Metabolic Endocrinology, 1996, 81; 2117-2120;
Wang, Z.L., R.M. Wang, R. Kulkarni, J.J. Ma, K. Meeran, W.M. Bennet, D.M.Smith, M.A. Ghatei and S.R. Bloom
Regulation of neuropeptide Y release is modulated by noradrenaline in both dexamethasone treated and control rat islets.
1996; P358: PI-895,
(Presentation at the 10th International Congress of Endocrinology, 12th-15th June, 1996. San Francisco, USA).
R. Kulkarn, Zhili Wang, Ren-Ming Wang, James D. Hurley, David M. Smith, Mohammad A. Ghatei, Dominic J. Withers, James V. Gardine, Cliff J. Bailey, and Stephen R. Bloom
Leptin rapidly suppresses insulin release from insulinoma cells, rat and Human islets and in vivo, in mice.
The Journal of Clinical Investigation 1997; 100:2729-2736.
Zhili Wang, Rohit N. Kulkarn, Ren-Ming Wang, David M. Smith, Mohammad A. Ghatei, Peter G.H.Byfield, Wiliam M. Bennet and Stephen R. Bloom
Possible evidence for endogenous production of a novel galanin-like peptide.
The Journal of Clinical Investigation 1997; 100:189-196.
D.G. Morgan, R.N.Kulkarni, J.D. Hurley, Z.L. Wang, R.M. Wang, M.A. Ghatei, A.E. Karlsen, S.R. Bloom, D.M. Smith
Inhibition of glucose stimulated insulin secretion by neuropeptide Y is mediated via the Y1 receptor and inhibition of adenylyl cyclase in RIN 5AH rat insulinoma cells.
Diabetologia 1998; 41: 1482-1491.
C. Mark, B. Edwards, Jeannie F. Todd, Mehdi Mahmoudi, Zhili Wang, Ren Ming Wang, Mohammad A. Ghatei, and Stephen R. Bloom
Glucagon-like Peptide 1 Has a Physiological Role in the Control of Postprandial Glucose in Humans Studies With the Antagonist Exendin 9-39.
Diabetes 1999; 48: 86-93.
R.N. Kulkarni, Z-L Wang, R-M Wang, D.M. Smith, M.A. Ghatei and S.R. Bloom
Glibenclamide but not other sulphonylureas stimulates release of neuropeptide Y from perifused rat islets and hamster insulinoma cells.
Journal of Endocrinology 2000; 165: 509-518 (In China).
Z.L. Wang, W. Yin, Z. Liu,
Relation between amino acids metabism and blood viscosity platelet aggregation, PGI2, TXB2, triglyceride in NIDDM.
Diabetes Research and Clinical Practice 1987; 13:58 (Supple).
Z.L. Wang, D.M. Yu
Effect of glibornuride on blood viscosity platelet aggregation, TXB2, PGI2, and the ratio of TXB2 to PGI2 in NIDDM.
Diabetes Research and Clinical Practice (supple) 1987; 13:18.
Z.L. Wang, W.Yin
Effect of sulphonylureas administration on insulin, C-peptide, glucagon secretion in NIDDM.
Diabetes Research and Clinical Practice (supple) 1987; 13:80.
W.Yin, Z.L. Wang
Glibornuride in the treatment of NIDDM.
Chinese Journal of Endocrinology and Metabolism 1989; 3:99-108.
Z.L. Wang, W.Yin
The Clinical study and method of urine C-peptide assay by solid phase RIA. Diabetes mellitus in east asia.
Elsevier Science Publishers B.V. (Biomedical Division) 1988; 293-295.
D.M. Yu, Z.L. Wang
Sacharoprotein determination in evaluation of therapeutic results of NIDDM.
Tianjin Medical Journal 1988; 16:20-22.
Z.L. Wang, Z.Y. Yin
Effect of “Ke, Tang Ling“ (Chinese Herbal Medicine) administration on the function of pancreatic islet α, β cells.
Chinese Journal of Integrated Traditional and Western Medicine 1990; 10(3): 137 140.
B.H. Du, Z.L. Wang
Repurification of radioactive iodine labelled six gastroenteric hormones.
Chinese Journal of medical Laboratory Technology 1987; 10(6):332-333.
Z.Liu, Z.L. Wang
Observations on secretory function of pancreatic islet α, and β cells in children with simple obesity.
Chinese Journal of Paediatrics 1988; 26(3):138-140.
J.C. Wang, Z.L. Wang
Pancreatic islet transplantation in treatment of IDDM.
Tianjin Medical Journal 1987; 15 (5) : 281-284.
D.M. Yu, Z.L. Wang
Plasma amino acid levels in Type 2 diabetes.
Tianjin Medical Journal 1987; 15(12):738-741.
D.M. Yu, Z.L. Wang
Preliminary observation of human fetal pancreatic islet α, β cells function and morphology.
Proceedings of the Chinese Academy of Medical Science and the Peking Union Medical College 1988;3:89.
The Special heart disease during diabetes patients.
Foreign Countries Medical Journal Section of Endocrinology 1983;2:112-114.
Prevention of insulin dependent diabetes mellitus.
Foreign Countries Medical Journal Section: Endocrinology 1984; 4:219-220.
Z.L. Wang, C.S.Xun, X. Wu
Serum oestrogen and testosterone in relation to the clinical course of acute myocardial infarction.
Journal of Clinical Medicine 1985;5:47-48.
X.Wu, Z.L. Wang, S.X. Chen
Acute myocardial infarction and platelet aggregation.
Tianjin Medical Journal 1985; 13:707-710.
Z.L. Wang, Z.Y. Zhang
Evaluation of the effect of GIK solution on acute myocardial infarction- Analysis of 506 cases.
Tianjin Medical Journal 1983;9:560-562.
X.Wu, Z.L. Wang
Acute myocardial infarction and blood viscosity.
Tianjin Medical Journal 1985;13:555-558.
S.X.Chen, Z.L. Wang
Preliminary study of the relationship between acute myocardial infarction and thyroid hormone.
Chinese Journal of Internal Medicine. 1988;27(6):339-340.