Imperial College London

DrZacharyWhinnett

Faculty of MedicineNational Heart & Lung Institute

Reader in Cardiac Electrophysiology
 
 
 
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z.whinnett

 
 
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Location

 

South- NHLI Cardiovascular ScienceBlock B Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

138 results found

Whinnett ZI, Francis DP, 2013, Cardiac Resynchronization Therapy Mechanisms in Atrial Fibrillation, HEART FAILURE CLINICS, Vol: 9, Pages: 475-+, ISSN: 1551-7136

Journal article

Kyriacou A, Wa MELK, Pabari PA, Unsworth B, Baruah R, Willson K, Peters NS, Kanagaratnam P, Hughes AD, Mayet J, Whinnett ZI, Francis DPet al., 2013, A systematic approach to designing reliable VV optimization methodology: Assessment of internal validity of echocardiographic, electrocardiographic and haemodynamic optimization of cardiac resynchronization therapy, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 167, Pages: 954-964, ISSN: 0167-5273

Journal article

Ploux S, Lumens J, Whinnett Z, Montaudon M, Strom M, Ramanathan C, Derval N, Zemmoura A, Denis A, De Guillebon M, Shah A, Hocini M, Jais P, Ritter P, Haissaguerre M, Wilkoff BL, Bordachar Pet al., 2013, Noninvasive Electrocardiographic Mapping to Improve Patient Selection for Cardiac Resynchronization Therapy Beyond QRS Duration and Left Bundle Branch Block Morphology, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 61, Pages: 2435-2443, ISSN: 0735-1097

Journal article

Bordachar P, Whinnett Z, Ploux S, Labrousse L, Haissaguerre M, Thambo J-Bet al., 2013, Pathophysiology, clinical course, and management of congenital complete atrioventricular block, HEART RHYTHM, Vol: 10, Pages: 760-766, ISSN: 1547-5271

Journal article

van Geldorp IE, Bordachar P, Lumens J, de Guillebon M, Whinnett ZI, Prinzen FW, Haissaguerre M, Delhaas T, Thambo J-Bet al., 2013, Acute hemodynamic benefits of biventricular and single-site systemic ventricular pacing in patients with a systemic right ventricle, HEART RHYTHM, Vol: 10, Pages: 676-682, ISSN: 1547-5271

Journal article

Barakat MF, Chehab O, Hayat S, Kelshiker M, Turner H, Norrington K, Konstantinou K, Whinnett Z, Koa-Wing M, Manisty C, Wright I, Jamil-Copley S, Lim B, Sutaria N, Nihoyannopoulos P, Lefroy D, Mayet J, Francis DP, Davies DW, Peters N, Kanagaratnam P, Okonko DOet al., 2013, ATTENUATIONS IN TISSUE DOPPLER-DERIVED LEFT VENTRICULAR SYSTOLIC VELOCITY PREDICT AN AMPLIFIED RISK OF LETHAL ARRHYTHMIAS IN ICD RECIPIENTS INDEPENDENTLY OF EJECTION FRACTION, 62nd Annual Scientific Session of the American-College-of-Cardiology, Publisher: ELSEVIER SCIENCE INC, Pages: E818-E818, ISSN: 0735-1097

Conference paper

Whinnett ZI, Francis DP, Denis A, Willson K, Pascale P, van Geldorp I, De Guillebon M, Ploux S, Ellenbogen K, Haissaguerre M, Ritter P, Bordachar Pet al., 2013, Comparison of different invasive hemodynamic methods for AV delay optimization in patients with cardiac resynchronization therapy: Implications for clinical trial design and clinical practice, International Journal of Cardiology, Vol: 168, Pages: 2228-2237, ISSN: 1874-1754

Journal article

Hayat SA, Kojodjojo P, Mason A, Benfield A, Wright I, Whinnett Z, Lim PB, Davies DW, Lefroy D, Peters NS, Kanagaratnam Pet al., 2013, Malfunction of Subpectorally Implanted Cardiac Resynchronization Therapy Defibrillators Due to Weakened Header Bond, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Vol: 24, Pages: 351-355, ISSN: 1045-3873

Journal article

Kyriacou A, Whinnett ZI, Davies JE, Pabari PA, Peters NS, Kanagaratnam P, Mayet J, Hughes AD, Francis DPet al., 2013, First-in-man evidence of the mechanistic effects of biventricular pacing on coronary physiology, Spring Meeting for Clinician Scientists in Training, Publisher: ELSEVIER SCIENCE INC, Pages: 62-62, ISSN: 0140-6736

Conference paper

Malcolme-Lawes LC, Lim PB, Koa-Wing M, Whinnett ZI, Jamil-Copley S, Hayat S, Francis DP, Kojodjojo P, Davies DW, Peters NS, Kanagaratnam Pet al., 2013, Robotic assistance and general anaesthesia improve catheter stability and increase signal attenuation during atrial fibrillation ablation, EUROPACE, Vol: 15, Pages: 41-47, ISSN: 1099-5129

Journal article

Mielewczik M, Cole GD, Nowbar AN, Schilling R, Whinnett ZI, Bordachar P, Wilmshurst P, Chambers JC, Olshansky B, Morgan J, otherset al., 2013, The C-CURE Randomized Clinical Trial (Cardiopoietic stem Cell therapy in heart failURE), Journal of the American College of Cardiology, Vol: 62, Pages: 2453-2453

Journal article

Whinnett ZI, Sohaib SMA, Davies DW, 2012, Diagnosis and management of supraventricular tachycardia, BMJ-BRITISH MEDICAL JOURNAL, Vol: 345, ISSN: 1756-1833

Journal article

Kyriacou A, Whinnett ZI, Sen S, Pabari PA, Wright I, Cornelussen R, Lefroy D, Davies DW, Peters NS, Kanagaratnam P, Mayet J, Hughes AD, Francis DP, Davies JEet al., 2012, Improvement in Coronary Blood Flow Velocity With Acute Biventricular Pacing Is Predominantly Due to an Increase in a Diastolic Backward-Travelling Decompression (Suction) Wave, CIRCULATION, Vol: 126, Pages: 1334-+, ISSN: 0009-7322

Journal article

Davies JE, Alastruey J, Francis DP, Hadjiloizou N, Whinnett ZI, Manisty CH, Aguado-Sierra J, Willson K, Foale RA, Malik IS, Hughes AD, Parker KH, Mayet Jet al., 2012, Attenuation of Wave Reflection by Wave Entrapment Creates a "Horizon Effect" in the Human Aorta, HYPERTENSION, Vol: 60, Pages: 778-+, ISSN: 0194-911X

Journal article

Sohaib SMA, Chen ZC, Whinnett Z, Francis DP, Manisty Cet al., 2012, Systematic review of genuine symptomatic response to cardiac resynchronization therapy: acknowledging the contribution of spontaneous response, Congress of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 995-995, ISSN: 0195-668X

Conference paper

Kyriacou A, Pabari PA, Whinnett ZI, Arri S, Willson K, Baruah R, Stegemann B, Mayet J, Kanagaratnam P, Hughes AD, Francis DPet al., 2012, Fully Automatable, Reproducible, Noninvasive Simple Plethysmographic Optimization: Proof of Concept and Potential for Implantability, PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, Vol: 35, Pages: 948-960, ISSN: 0147-8389

Journal article

Ploux S, Whinnett Z, Lumens J, Denis A, Zemmoura A, De Guillebon M, Ramoul K, Ritter P, Jaïs P, Clementy J, Haïssaguerre M, Bordachar Pet al., 2012, Acute hemodynamic response to biventricular pacing in heart failure patients with narrow, moderately, and severely prolonged QRS duration, Heart Rhythm, Vol: 9, Pages: 1247-1250, ISSN: 1547-5271

Journal article

Pascale P, Shah AJ, Roten L, Whinnett Z, Wilton SB, Jadidi AS, Scherr D, Miyazaki S, Pedersen M, Derval N, Knecht S, Sacher F, Hocini M, Haïssaguerre M, Jaïs Pet al., 2012, Disparate activation of the coronary sinus and inferior left atrium during atrial tachycardia after persistent atrial fibrillation ablation: prevalence, pitfalls, and impact on mapping., J Cardiovasc Electrophysiol, Vol: 23, Pages: 697-707

INTRODUCTION: Persistent atrial fibrillation (AF) ablation may lead to partial disconnection of the coronary sinus (CS). As a result, disparate activation sequences of the local CS versus contiguous left atrium (LA) may be observed during atrial tachycardia (AT). We aimed to evaluate the prevalence of this phenomenon and its impact on activation mapping. METHODS: AT occurring after persistent AF ablation were investigated in 74 consecutive patients. Partial CS disconnection during AT was suspected when double potentials with disparate activation sequences were observed on the CS catheter. Endocardial mapping facing CS bipoles was performed to differentiate LA far-field from local CS potentials. RESULTS: A total of 149 ATs were observed. Disparate LA-CS activations were apparent in 20 ATs after magnifying the recording scale (13%). The most common pattern (90%) was distal to proximal endocardial LA activation against proximal to distal CS activation, the latter involving the whole CS or its distal part. Perimitral macroreentry was more common when disparate LA-CS activations were observed (67% vs 29%; P = 0.002). Partial CS disconnection also resulted in "pseudo" mitral isthmus (MI) block during LA appendage pacing in 20% of patients as local CS activation was proximal to distal despite distal to proximal activation of the contiguous LA. CONCLUSION: Careful analysis of CS recordings during AT following persistent AF ablation often reveals disparate patterns of activation. Recognizing when endocardial LA activation occurs in the opposite direction to the more obvious local CS signals is critical to avoid misleading interpretations during mapping of AT and evaluation of MI block.

Journal article

PLOUX S, VERDOUX H, WHINNETT Z, RITTER P, SANTOS PD, PICARD F, CLEMENTY J, HAÏSSAGUERRE M, BORDACHAR Pet al., 2012, Depression and Severe Heart Failure: Benefits of Cardiac Resynchronization Therapy, Journal of Cardiovascular Electrophysiology, Vol: 23, Pages: 631-636, ISSN: 1045-3873

Journal article

Kyriacou A, Wa MLK, Pabari P, Kanagaratnam P, Peters NS, Mayet J, Francis DP, Whinnett ZIet al., 2012, SHOULD CURRENT MODALITIES OF VV OPTIMISATION BE TRUSTED? AN ASSESSMENT OF THE INTERNAL VALIDITY OF ECHOCARDIOGRAPHIC, ELECTROCARDIOGRAPHIC AND HAEMODYNAMIC MODALITIES OF OPTIMISATION, Annual Conference of the British-Cardiovascular-Society (BCS), Publisher: B M J PUBLISHING GROUP, Pages: A8-A8, ISSN: 1355-6037

Conference paper

Sohaib SMA, Chen Z, Whinnett Z, Francis DP, Manisty Cet al., 2012, UNBIASED ASSESSMENT OF SYMPTOMATIC "RESPONSE RATE" TO CARDIAC RESYNCHRONISATION THERAPY BY SYSTEMATIC REVIEW OF RANDOMISED CONTROLLED TRIALS (REVERSE, MIRACLE, MIRACLE ICD, MIRACLE ICD II, CARE-HF, COMPANION, CONTAK-CD, AND MUSTIC), Annual Conference of the British-Cardiovascular-Society (BCS), Publisher: B M J PUBLISHING GROUP, Pages: A4-A4, ISSN: 1355-6037

Conference paper

Pabari PA, Kyriacou A, Wright I, Hughes AD, Mayet J, Whinnett ZI, Francis DP, Manisty CHet al., 2012, SIMULTANEOUS INVASIVE PRESSURE AND FLOW MEASUREMENTS DURING ATRIOVENTRICULAR DELAY IMPROVEMENT REVEAL A COMPENSATORY PERIPHERAL VASODILATOR RESPONSE WHICH ATTENUATES THE INITIAL BLOOD PRESSURE INCREMENT: IMPLICATIONS FOR THE DESIGN OF OPTIMISATION PROTOCOLS, Annual Conference of the British-Cardiovascular-Society (BCS), Publisher: BMJ PUBLISHING GROUP, Pages: A5-A6, ISSN: 1355-6037

Conference paper

Kyriacou A, Whinnett ZI, Sen S, Pabari P, Davies DW, Peters NS, Kanagaratnam P, Mayet J, Hughes AD, Francis DP, Davies JEet al., 2012, IMPROVEMENT IN CORONARY BLOOD FLOW WITH ACUTE BIVENTRICULAR PACING IS PREDOMINANTLY DUE TO AN INCREASE IN A DIASTOLIC BACKWARD-TRAVELLING DECOMPRESSION (SUCTION) WAVE, Annual Conference of the British-Cardiovascular-Society (BCS), Publisher: B M J PUBLISHING GROUP, Pages: A7-A8, ISSN: 1355-6037

Conference paper

Ploux S, Whinnett Z, Bordachar P, 2012, Left Ventricular Endocardial Pacing and Multisite Pacing to Improve CRT Response, Journal of Cardiovascular Translational Research, Vol: 5, Pages: 213-218, ISSN: 1937-5387

Journal article

JAN E, CAMOU F, TEXIER-MAUGEIN J, WHINNETT Z, CAUBET O, PLOUX S, PELLEGRIN J-L, RITTER P, METAYER PL, ROUDAUT R, HAISSAGUERRE M, BORDACHAR Pet al., 2012, Microbiologic Characteristics and In Vitro Susceptibility to Antimicrobials in a Large Population of Patients with Cardiovascular Implantable Electronic Device Infection, Journal of Cardiovascular Electrophysiology, Vol: 23, Pages: 375-381, ISSN: 1045-3873

Journal article

Manisty CH, Al-Hussaini A, Unsworth B, Baruah R, Pabari PA, Mayet J, Hughes AD, Whinnett ZI, Francis DPet al., 2012, The Acute Effects of Changes to AV Delay on BP and Stroke Volume Potential Implications for Design of Pacemaker Optimization Protocols, CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, Vol: 5, Pages: 122-U209, ISSN: 1941-3149

Journal article

Whinnett Z, Bordachar P, 2012, The risks and benefits of transseptal endocardial pacing, CURRENT OPINION IN CARDIOLOGY, Vol: 27, Pages: 19-23, ISSN: 0268-4705

Journal article

Ploux S, Riviere A, Amraoui S, Whinnett Z, Barandon L, Lafitte S, Ritter P, Papaioannou G, Clementy J, Jais P, Bordenave L, Haissaguerre M, Bordachar Pet al., 2011, Positron emission tomography in patients with suspected pacing system infections may play a critical role in difficult cases, Heart Rhythm, Vol: 8, Pages: 1478-1481, ISSN: 1547-5271

Journal article

Kyriacou A, Pabari P, Wright I, Cornellussen R, Sen S, Mayet J, Peters N, Kanagaratnam P, Whinnett Z, Francis DPet al., 2011, The effect of cardiac resynchronization therapy and of atrioventricular delay optimization on mechanoenergetic efficiency: simply, a better value for money, EUROPEAN HEART JOURNAL, Vol: 32, Pages: 151-151, ISSN: 0195-668X

Journal article

Pabari PA, Kyriacou A, Whinnett ZI, Wright I, Willson K, Mayet J, Hughes AD, Francis DPet al., 2011, Invasive evaluation of whether decline in pressure after initial immediate increment on improving AV delay of CRT is due to vasodilatation or decline in cardiac function, EUROPEAN HEART JOURNAL, Vol: 32, Pages: 782-782, ISSN: 0195-668X

Journal article

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