Imperial College London

DrZacharyWhinnett

Faculty of MedicineNational Heart & Lung Institute

Reader in Cardiac Electrophysiology
 
 
 
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Contact

 

z.whinnett

 
 
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Location

 

South- NHLI Cardiovascular ScienceBlock B Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

138 results found

Manisty CH, Unsworth B, Baruah R, Pabari P, Whinnett ZI, Mayet J, Francis DPet al., 2011, PRESSURE VS FLOW AS A GUIDE FOR PACEMAKER OPTIMISATION? THE ACUTE HAEMODYNAMIC EFFECTS OF CHANGES TO ATRIOVENTRICULAR DELAY, Annual Conference of the British-Cardiovascular-Society (BCS), Publisher: B M J PUBLISHING GROUP, Pages: A58-A58, ISSN: 1355-6037

Conference paper

Whinnett ZI, Nott G, Davies JER, Willson K, Manisty CH, Kanagaratnam P, Peters NS, Davies DW, Hughes AD, Mayet J, Francis DPet al., 2011, Maximizing Efficiency of Alternation Algorithms for Hemodynamic Optimization of the AV Delay of Cardiac Resynchronization Therapy, PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, Vol: 34, Pages: 217-225, ISSN: 0147-8389

Journal article

Pabari PA, Kyriacou A, Whinnett ZI, Wright I, Willson K, Mayet J, Hughes AD, Francis DPet al., 2011, Invasive evaluation of whether decline in pressure after initial immediate increment on improving AV delay of CRT is due to vasodilatation or decline in cardiac function, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 183, Pages: 782-782, ISSN: 1073-449X

Journal article

Kojodjojo P, O'Neill MD, Lim PB, Malcolm-Lawes L, Whinnett ZI, Salukhe TV, Linton NW, Lefroy D, Mason A, Wright I, Peters NS, Kanagaratnam P, Davies DWet al., 2010, Pulmonary venous isolation by antral ablation with a large cryoballoon for treatment of paroxysmal and persistent atrial fibrillation: medium-term outcomes and non-randomised comparison with pulmonary venous isolation by radiofrequency ablation, Heart, Vol: 96, Pages: 1379-1384, ISSN: 1468-201X

Background To prevent atrial fibrillation (AF) recurrenceafter catheter ablation, pulmonary venous isolation (PVI)at an antral level is more effective than segmental ostialablation. Cryoablation around the pulmonary venous (PV)ostia for AF therapy is potentially safer compared toradiofrequency ablation (RFA). The aim of this study wasto investigate the efficacy of a strategy using a largecryoablation balloon to perform antral cryoablation with‘touch-up’ ostial cryoablation for PVI in patients withparoxysmal and persistent AF.Methods Paroxysmal and persistent AF patientsundergoing their first left atrial ablation were recruited.After cryoballoon therapy, each PV was assessed forisolation and if necessary, treated with focal ostialcryoablation until PVI was achieved. Follow-up withHolter monitoring was performed. Clinical outcomes ofthe cryoablation protocol were compared, withconsecutive patients undergoing PVI by RFA.Results 124 consecutive patients underwentcryoablation. 77% of paroxysmal and 48% of persistentAF subjects were free from AF at 12 months aftera single procedure. Over the same time period, 53consecutive paroxysmal AF subjects underwent PVI withRFA and at 12 months, 72% were free from AF at12 months (p¼NS). There were too few persistent AFsubjects (n¼8) undergoing solely PVI by RFA asa comparison group. Procedural and fluoroscopic timesduring cryoablation were significantly shorter than RFA.Conclusions PV isolation can be achieved in less than2 h by a simple cryoablation protocol with excellentresults after a single intervention, particularly forparoxysmal AF.

Journal article

Kyriacou A, Whinnett ZI, Pabari PA, Willson K, Lefroy D, Davies DW, Peters NS, Mayet J, Kanagaratnam P, Francis DPet al., 2010, Adaptation of non-invasive haemodynamic technologies and development of algorithms for cost effective, automated optimisation of cardiac resynchronisation devices, ESC Congress, Publisher: OXFORD UNIV PRESS, Pages: 418-418, ISSN: 0195-668X

Conference paper

Davies JE, Baksi J, Francis DP, Hadjiloizou N, Whinnett ZI, Manisty CH, Aguado-Sierra J, Foale RA, Malik IS, Tyberg JV, Parker KH, Mayet J, Hughes ADet al., 2010, The arterial reservoir pressure increases with aging and is the major determinant of the aortic augmentation index, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 298, Pages: H580-H586, ISSN: 0363-6135

Journal article

Davies JE, Francis DP, Hadjiloizou N, Whinnett ZI, Manisty CH, Aguado-Sierra J, Malik IS, Parker KH, Hughes AD, Mayet Jet al., 2010, Augmentation of Coronary Blood Flow in Systole by Reflected Waves in the Proximal Aorta, 11th International Congress of the IUPESM/World Congress on Medical Physics and Biomedical Engineering, Publisher: SPRINGER, Pages: 61-64, ISSN: 1680-0737

Conference paper

Linton NWF, Koa-Wing M, Francis DP, Kojodjojo P, Lim PB, Salukhe TV, Whinnett Z, Davies DW, Peters NS, O'Neill MD, Kanagaratnam Pet al., 2009, Cardiac ripple mapping: A novel three-dimensional visualization method for use with electroanatomic mapping of cardiac arrhythmias, HEART RHYTHM, Vol: 6, Pages: 1754-1762, ISSN: 1547-5271

Journal article

Koa-Wing M, Kojodjojo P, Malcolme-Lawes LC, Salukhe TV, Linton NWF, Grogan AP, Bergman D, Lim PB, Whinnett ZI, McCarthy K, Ho SY, O'Neill MD, Peters NS, Davies DW, Kanagaratnam Pet al., 2009, Robotically Assisted Ablation Produces More Rapid and Greater Signal Attenuation Than Manual Ablation, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Vol: 20, Pages: 1398-1404, ISSN: 1045-3873

Journal article

Lim PB, Stuber T, Koa-Wing M, Salukhe TV, Linton NWF, Kojodjojo P, Whinnett ZI, Francis DP, Davies DW, Peters NS, O'Neill MD, Kanagaratnam Pet al., 2009, ACTIVATION OF THE INTRINSIC CARDIAC AUTONOMIC NERVOUS SYSTEM INDUCES ECTOPY, INITIATING ATRIAL FIBRILLATION AND RESULTS IN A GRADIENT OF SHORTENING IN ATRIAL FIBRILLATION CYCLE LENGTHS IN THE PULMONARY VEINS AND ATRIA, Annual Scientific Conference of the British-Cardiovascular-Society, Publisher: B M J PUBLISHING GROUP, Pages: A1-A3, ISSN: 1355-6037

Conference paper

Raphael CE, Whinnett ZI, Davies JE, Fontana M, Ferenczi EA, Manisty CH, Mayet J, Francis DPet al., 2009, Quantifying the paradoxical effect of higher systolic blood pressure on mortality in chronic heart failure, HEART, Vol: 95, Pages: 56-62, ISSN: 1355-6037

Journal article

Whinnett ZI, Francis DP, 2008, To the editor-response., Heart Rhythm, Vol: 5, Pages: e4-e4, ISSN: 1556-3871

Journal article

Davies JER, Whinnett ZI, Hadjiloizou N, Aguado-Sierra J, Parker KH, Francis DP, Hughes AD, Mayet Jet al., 2008, Evidence of augmentation of systolic coronary blood flow by retrograde wave reflection travelling-back from the proximal aorta, JOURNAL OF HUMAN HYPERTENSION, Vol: 22, Pages: 718-719, ISSN: 0950-9240

Journal article

Whinnett ZI, Davies JER, Nott G, Willson K, Manisty CH, Peters NS, Kanagaratnam P, Davies DW, Hughes AD, Mayet J, Francis DPet al., 2008, Efficiency, reproducibility and agreement of five different hemodynamic measures for optimization of cardiac resynchronization therapy, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 129, Pages: 216-226, ISSN: 0167-5273

Journal article

Manisty CH, Willson K, Davies JER, Whinnett ZI, Baruah R, Mebrate Y, Kanagaratnam P, Peters NS, Hughes AD, Mayet J, Francis DPet al., 2008, Induction of oscillatory ventilation pattern using dynamic modulation of heart rate through a pacemaker, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, Vol: 295, Pages: R219-R227, ISSN: 0363-6119

Journal article

Davies JE, Whinnett ZI, Hadjiloizou N, Manisty CH, Hughes AD, Parker KH, Francis DP, Mayet Jet al., 2008, Microcirculatory-originating pressure predominantly determines coronary blood flow in humans: Evaluation using wave intensity analysis, Annual Scientific Conference of the British-Cardiovascular-Society/British-Society-for-Cardiovascular-Research, Publisher: B M J PUBLISHING GROUP, Pages: A121-+, ISSN: 1355-6037

Conference paper

Davies JE, Hadjiloizou N, Manisty CH, Whinnett ZI, Francis DP, Parker KH, Mayet J, Hughes ADet al., 2008, Evidence to support the role of the aortic reservoir via a direct mechanism in determination of the pressure waveform with ageing, 57th Annual Scientific Session of the American-College-of-Cardiology, Publisher: ELSEVIER SCIENCE INC, Pages: A339-A339, ISSN: 0735-1097

Conference paper

Whinnett ZI, Briscoe C, Davies JE, Willson K, Manisty CH, Davies DW, Peters NS, Kanagaratnam P, Hughes AD, Mayet J, Francis DPet al., 2008, The atrioventricular delay of cardiac resynchronization can be optimized hemodynamically during exercise and predicted from resting measurements., Heart Rhythm, Vol: 5, Pages: 378-386, ISSN: 1547-5271

Atrioventricular (AV) optimization of cardiac resynchronization therapy (CRT) is typically calculated at rest. However, patients often become symptomatic during exercise.

Journal article

Manisty C, Willson K, Davies JE, Whinnett ZI, Mebrate Y, Oldfield WLG, Hughes A, Mayet J, Francis DPet al., 2007, Cardiac output manipulation using pacemakers to dynamically modulate ventilation: a new potential therapeutic avenue for periodic breathing in heart failure, EUROPEAN HEART JOURNAL, Vol: 28, Pages: 872-872, ISSN: 0195-668X

Journal article

Hadjiloizou N, Davies JE, Manisty CH, Whinnett ZI, Francis DP, Willson K, Malik IS, Hughes AD, Parker KH, Mayet Jet al., 2007, Physiological mechansims underlying the differences in flow velocity in the left and right coronary arteries, EUROPEAN HEART JOURNAL, Vol: 28, Pages: 753-753, ISSN: 0195-668X

Journal article

Manisty C, Willson K, Hadjiloizou N, Davies JE, Whinnett ZI, Hughes AD, Mayet J, Francis DPet al., 2007, Chemoreflex gain: a physiological reflex without adaptation?, EUROPEAN HEART JOURNAL, Vol: 28, Pages: 873-873, ISSN: 0195-668X

Journal article

Manisty C, Davies J, Whinnett Z, Francis D, Zambanini A, Zambanini A, Curtis S, Thom S, Hughes A, Mayet Jet al., 2007, Differences in the magnitude rather than the timing of wave reflection can explain the ASCOT results, Annual Scientific Conference of the British-Cardiovascular-Society, Publisher: B M J PUBLISHING GROUP, Pages: A80-A80, ISSN: 1355-6037

Conference paper

Davies J, Hadjiloizou N, Manisty C, Whinnett Z, Foale R, Malik I, Hughes A, Parker K, Darrel D, Mayet Jet al., 2007, A unifying explanation of the arterial pulse waveform in humans and the implications for central blood pressure augmentation, Annual Scientific Conference of the British-Cardiovascular-Society, Publisher: B M J PUBLISHING GROUP, Pages: A79-A80, ISSN: 1355-6037

Conference paper

Raphael C, Briscoe C, Davies J, Whinnett ZI, Manisty C, Sutton R, Mayet J, Francis DPet al., 2007, Limitations of the New York Heart Association functional classification system and self-reported walking distances in chronic heart failure, HEART, Vol: 93, Pages: 476-482, ISSN: 1355-6037

Journal article

Davies JE, Hadjiloizou N, Leibovich D, Malaweera A, Alastruey J, Whinnett ZI, Manisty CH, Francis DP, Aguado-Sierra J, Foale RA, Malik IS, Parker KH, Mayet J, Hughes ADet al., 2007, Importance of the aortic reservoir in determining the shape of the arterial pressure waveform - The forgotten lessons of Frank, Artery Research, Vol: 1, Pages: 40-45

It has been recognised for nearly 200 years that the human pressure waveform changes in shape with ageing and disease. The shape of the pressure waveform has been explained in terms of two fundamental models: the Windkessel (reservoir) and wave theory. In its simplest form the Windkessel model satisfactorily explains the pressure waveform in diastole but cannot model pressure changes in systole. Wave theory satisfactorily models the pressure waveform but predicts the existence of ‘self-cancelling’ forward and backward waves in diastole which are difficult to explain in biological terms. We propose that a hybrid reservoir–wave model better describes the pressure waveform and may enable assessment of aortic function from pressure measurements made at any large systemic artery.

Journal article

Manisty CH, Willson K, Wensel R, Whinnett ZI, Davies JE, Oldfield WLG, Mayet J, Francis DPet al., 2006, Apnoeic threshold: A true determinant of cardiorespiratory control stability or a marker of chemoreflex gain?, Winter Meeting of the British-Thoracic-Society/British-Lung-Foundation (BTS/BLF), Publisher: B M J PUBLISHING GROUP, Pages: II48-II49, ISSN: 0040-6376

Conference paper

Manisty CH, Willson K, Davies JE, Whinnett ZI, Oldfield WLG, Hughes A, Mayet J, Francis DPet al., 2006, Can cardiac pacemakers directly control ventilation?, Winter Meeting of the British-Thoracic-Society/British-Lung-Foundation (BTS/BLF), Publisher: B M J PUBLISHING GROUP, Pages: II49-II49, ISSN: 0040-6376

Conference paper

Manisty CH, Willson K, Wensel R, Whinnett ZI, Davies JE, Oldfield WLG, Mayet J, Francis DPet al., 2006, Development of respiratory control instability in heart failure: a novel approach to dissect the pathophysiological mechanisms, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 577, Pages: 387-401, ISSN: 0022-3751

Journal article

Whinnett ZI, Davies JER, Willson K, Manisty CH, Chow AW, Foale RA, Davies DW, Hughes AD, Mayet J, Francis DPet al., 2006, Haemodynamic effects of changes in atrioventricular and interventricular delay in cardiac resynchronisation therapy show a consistent pattern: Analysis of shape, magnitude and relative importance of atrioventricular and interventricular delay, HEART, Vol: 92, Pages: 1628-1634, ISSN: 1355-6037

Journal article

Manisty CH, Davies JE, Zambanini A, Curtis SL, Whinnett ZI, Thom SM, Francis DP, Hughes AD, Mayet Jet al., 2006, Differential arterial wave reflection in ASCOT: An explanation for the results?, 79th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 537-537, ISSN: 0009-7322

Conference paper

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