Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Reader in Cardiac Electrophysiology







South- NHLI Cardiovascular ScienceBlock B Hammersmith HospitalHammersmith Campus






BibTex format

author = {Ali, N and Keene, D and Arnold, A and Shun-Shin, M and Whinnett, ZI and Sohaib, SMA},
doi = {10.15420/aer.2018.6.2},
journal = {Arrhythmia & electrophysiology review},
pages = {103--110},
title = {His bundle pacing: a new frontier in the treatment of heart failure},
url = {},
volume = {7},
year = {2018}

RIS format (EndNote, RefMan)

AB - Biventricular pacing has revolutionised the treatment of heart failure in patients with sinus rhythm and left bundle branch block; however, left ventricular-lead placement is not always technically possible. Furthermore, biventricular pacing does not fully normalise ventricular activation and, therefore, the ventricular resynchronisation is imperfect. Right ventricular pacing for bradycardia may cause or worsen heart failure in some patients by causing dyssynchronous ventricular activation. His bundle pacing activates the ventricles via the native His-Purkinje system, resulting in true physiological pacing, and, therefore, is a promising alternate site for pacing in bradycardia and traditional CRT indications in cases where it can overcome left bundle branch block. Furthermore, it may open up new indications for pacing therapy in heart failure, such as targeting patients with PR prolongation, but a narrow QRS duration. In this article we explore the physiology, technology and potential roles of His bundle pacing in the prevention and treatment of heart failure.
AU - Ali,N
AU - Keene,D
AU - Arnold,A
AU - Shun-Shin,M
AU - Whinnett,ZI
AU - Sohaib,SMA
DO - 10.15420/aer.2018.6.2
EP - 110
PY - 2018///
SN - 2050-3369
SP - 103
TI - His bundle pacing: a new frontier in the treatment of heart failure
T2 - Arrhythmia & electrophysiology review
UR -
UR -
VL - 7
ER -