Imperial College London

DrZacharyWhinnett

Faculty of MedicineNational Heart & Lung Institute

Reader in Cardiac Electrophysiology
 
 
 
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Contact

 

z.whinnett

 
 
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Location

 

South- NHLI Cardiovascular ScienceBlock B Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Leong:2017:10.1016/j.amjcard.2017.10.027,
author = {Leong, KMW and chow, J-J and Ng, FS and Falaschetti, E and Qureshi, N and Koa-Wing, M and Linton, N and Whinnett, Z and Lefroy, D and Davies, DW and Lim, PB and Peters, N and Kanagaratnam, P and Varnava, A and Leong, KMW and Chow, J and Ng, FS and falaschetti, E and Qureshi, N and Koa-Wing, M and Linton, N and Whinnett, Z and Lefroy, DC and Davies, DW and Lim, PB and Peters, N and Kanagaratnam, P and Varnava, AM},
doi = {10.1016/j.amjcard.2017.10.027},
journal = {American Journal of Cardiology},
pages = {349--355},
title = {Comparison of the Prognostic Usefulness of the European Society of Cardiology and American Heart Association/American College of Cardiology Foundation Risk Stratification Systems for Patients With Hypertrophic Cardiomyopathy},
url = {http://dx.doi.org/10.1016/j.amjcard.2017.10.027},
volume = {121},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Implantable cardio-defibrillators (ICDs) have proven benefit in preventing sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HC), making risk stratification essential. Data on the predictive accuracy on the European Society of Cardiology (ESC) risk scoring system has been conflicting. We independently evaluated the ESC risk scoring system in our cohort of HC patients from a large tertiary centre and compared this to previous guidance by the American College of Cardiology Foundation and Heart Association (ACCF/AHA). Risk factor profiles, 5-year SCD risk estimates and ICD recommendations as defined by the ACCF/AHA and ESC guidelines, were retrospectively ascertained for 288 HC patients with and without SCD or equivalent events at our centre. In the SCD group (n=14), a significantly higher proportion of patients would not have met the criteria for an ICD implant using the ESC scoring algorithm than ACCF/AHA guidance (43%vs7%, p=0.029). In those without SCD events (n=274), a larger proportion of individuals not requiring an ICD was identified using the ESC risk score model compared to the ACCF/AHA model (82%vs57%; p<0.0001). Based on risk stratification criteria alone, 5 more individuals with a previously aborted SCD event would not have received an ICD with the ESC risk model than the ACCF/AHA risk model. In conclusion, we found that the current ESC scoring system potentially leaves more high-risk patients unprotected from sudden death in our cohort of patients.
AU - Leong,KMW
AU - chow,J-J
AU - Ng,FS
AU - Falaschetti,E
AU - Qureshi,N
AU - Koa-Wing,M
AU - Linton,N
AU - Whinnett,Z
AU - Lefroy,D
AU - Davies,DW
AU - Lim,PB
AU - Peters,N
AU - Kanagaratnam,P
AU - Varnava,A
AU - Leong,KMW
AU - Chow,J
AU - Ng,FS
AU - falaschetti,E
AU - Qureshi,N
AU - Koa-Wing,M
AU - Linton,N
AU - Whinnett,Z
AU - Lefroy,DC
AU - Davies,DW
AU - Lim,PB
AU - Peters,N
AU - Kanagaratnam,P
AU - Varnava,AM
DO - 10.1016/j.amjcard.2017.10.027
EP - 355
PY - 2017///
SN - 0002-9149
SP - 349
TI - Comparison of the Prognostic Usefulness of the European Society of Cardiology and American Heart Association/American College of Cardiology Foundation Risk Stratification Systems for Patients With Hypertrophic Cardiomyopathy
T2 - American Journal of Cardiology
UR - http://dx.doi.org/10.1016/j.amjcard.2017.10.027
UR - http://hdl.handle.net/10044/1/53840
VL - 121
ER -