Imperial College London
Alternate

DrZacharyWhinnett

Faculty of Medicine, National Heart & Lung Institute

Reader in Cardiac Electrophysiology
 
 
 
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Contact

 

z.whinnett

 
 
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Location

 

South- NHLI Cardiovascular ScienceBlock B Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
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212 results found

Finegold J, Bordachar P, Kyriacou A, Sohaib SMA, Kanagaratnam P, Ploux S, Lim B, Peters N, Davies DW, Lefroy D, Ritter P, Francis D, Whinnett Zet al., 2014, CORRELATION AND REPRODUCIBILITY OF INVASIVE AND NON-INVASIVE HAEMODYNAMIC PARAMETERS FOR IDENTIFYING OPTIMAL AV DELAY IN CARDIAC RESYNCHRONISATION THERAPY, HEART, Vol: 100, Pages: A22-A23, ISSN: 1355-6037

Journal article

Finegold J, Cazeau S, Sohaib SMA, Kyriacou A, Manisty C, Ritter P, Bordachar P, Whinnett Z, Francis Det al., 2014, THE EFFECT OF ALTERING AV DELAY ON THE PRE-EJECTION PERIOD IN PATIENTS WITH BIVENTRICULAR PACEMAKERS, HEART, Vol: 100, Pages: A22-A22, ISSN: 1355-6037

Journal article

Whinnett ZI, Sohaib SMA, Jones S, Kyriacou A, March K, Coady E, Mayet J, Hughes AD, Frenneaux M, Francis DPet al., 2014, British randomised controlled trial of AV and VV optimization ("BRAVO") study: rationale, design, and endpoints, BMC CARDIOVASCULAR DISORDERS, Vol: 14, ISSN: 1471-2261

Journal article

Jamil-Copley S, Bokan R, Kojodjojo P, Qureshi N, Koa-Wing M, Hayat S, Kyriacou A, Sandler B, Sohaib A, Wright I, Davies DW, Whinnett Z, Peters NS, Kanagaratnam P, Lim PBet al., 2014, Noninvasive electrocardiographic mapping to guide ablation of outflow tract ventricular arrhythmias, HEART RHYTHM, Vol: 11, Pages: 587-594, ISSN: 1547-5271

Journal article

Jones S, Shun-Shin MJ, Cole GD, Sau A, March K, Williams S, Kyriacou A, Hughes AD, Mayet J, Frenneaux M, Manisty CH, Whinnett ZI, Francis DPet al., 2014, Applicability of the iterative technique for cardiac resynchronization therapy optimization: full-disclosure, 50-sequential-patient dataset of transmitral Doppler traces, with implications for future research design and guidelines, EUROPACE, Vol: 16, Pages: 541-550, ISSN: 1099-5129

Journal article

Kyriacou A, Pabari PA, Mayet J, Peters NS, Davies DW, Lim PB, Lefroy D, Hughes AD, Kanagaratnam P, Francis DP, Whinnett ZIet al., 2014, Cardiac resynchronization therapy and AV optimization increase myocardial oxygen consumption, but increase cardiac function more than proportionally, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 171, Pages: 144-152, ISSN: 0167-5273

Journal article

Nijjer SS, Sohaib SMA, Whinnett ZI, Lefroy DCet al., 2014, Management of supraventricular tachycardias, BRITISH JOURNAL OF HOSPITAL MEDICINE, Vol: 75, Pages: C26-C28, ISSN: 1750-8460

Journal article

Nijjer SS, Sohaib SMA, Hinnett ZI, Lefroy DCet al., 2014, Diagnosis of supraventricular tachycardias, BRITISH JOURNAL OF HOSPITAL MEDICINE, Vol: 75, Pages: C22-C25, ISSN: 1750-8460

Journal article

Bouri S, Whinnett ZI, Cole GD, Manisty CH, Cleland JG, Francis DPet al., 2014, Definitions of Outcome, Response and Effect in Imaging Research to Avoid Confusion, JACC-CARDIOVASCULAR IMAGING, Vol: 7, Pages: 104-106, ISSN: 1936-878X

Journal article

Finegold JA, Raphael CE, Levy WC, Whinnett Z, Francis DPet al., 2013, Quantification of survival gain from cardiac resynchronization therapy: nonlinear growth with time, and greater gain in low-risk patients, make raw trial data an underestimate of real-world behavior., J Am Coll Cardiol, Vol: 62, Pages: 2406-2413

OBJECTIVES: The goal of this study was to examine the impact of calculation-window duration on lifespan gain (as observed in trials) and on who gains most. BACKGROUND: The landmark trials of biventricular pacing (cardiac resynchronization therapy [CRT]) typically ran for <1 device battery life, and they may therefore underestimate lifespan benefit over longer durations. METHODS: We conducted a meta-analysis of biventricular pacing trials to calculate lifespan gained: first, within the duration of randomized controlled trial data up to 2 years; second, over a 5-year typical battery life; and third, over >1 battery life. Importantly, we applied the Gompertz method for age-related increase in mortality from non-CRT-preventable causes. RESULTS: Five landmark trials (COMPANION [Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure], CARE-HF (CArdiac REsynchronization-Heart Failure), MADIT-CRT [Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy], REVERSE [Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction], RAFT (Resynchronization-Defibrillation for Ambulatory Heart Failure)) provided data for 2 years (6,561 patients), with an average hazard ratio of 0.71. Lifespan gained across all trials increased nonlinearly with time from 0.1 month at 1 year, to 0.5 month at 2 years, and a projected 6.5 months at 5 years (65 times more than at 1 year). After multiple devices, it reached 14 months, involving on average 1.6 devices (i.e., 8.8 months per device implanted). Moreover, while over a short window (e.g., 2 years), lower-mortality patients may gain less than higher-mortality patients (1.4 vs. 2.3 months), their positions reverse by 15 years (16.0 vs. 13.7 months). CONCLUSIONS: Lifespan gain from biventricular pacing rises nonlinearly with time. Early on, higher-risk patients exhibit more gain, but later, lower-risk patients exhibit more gain. Quantifying ga

Journal article

Sohaib SMA, Whinnett ZI, Ellenbogen KA, Stellbrink C, Quinn TA, Bogaard MD, Bordachar P, van Gelder BM, van Geldorp IE, Linde C, Meine M, Prinzen FW, Turcott RG, Spotnitz HM, Wichterle D, Francis DPet al., 2013, Cardiac resynchronisation therapy optimisation strategies: Systematic classification, detailed analysis, minimum standards and a roadmap for development and testing, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 170, Pages: 118-131, ISSN: 0167-5273

Journal article

Sohaib SMA, Chen Z, Whinnett ZI, Bouri S, Dickstein K, Linde C, Hayes DL, Manisty CH, Francis DPet al., 2013, Meta-analysis of symptomatic response attributable to the pacing component of cardiac resynchronization therapy, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 15, Pages: 1419-1428, ISSN: 1388-9842

Journal article

Jamil-Copley S, Linton N, Koa-Wing M, Kojodjojo P, Lim PB, Malcolme-Lawes L, Whinnett Z, Wright I, Davies W, Peters N, Francis DP, Kanagaratnam Pet al., 2013, Application of Ripple Mapping with an Electroanatomic Mapping System for Diagnosis of Atrial Tachycardias, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Vol: 24, Pages: 1361-1369, ISSN: 1045-3873

Journal article

Whinnett ZI, Francis DP, 2013, Cardiac Resynchronization Therapy Mechanisms in Atrial Fibrillation, HEART FAILURE CLINICS, Vol: 9, Pages: 475-+, ISSN: 1551-7136

Journal article

Kyriacou A, Wa MELK, Pabari PA, Unsworth B, Baruah R, Willson K, Peters NS, Kanagaratnam P, Hughes AD, Mayet J, Whinnett ZI, Francis DPet al., 2013, A systematic approach to designing reliable VV optimization methodology: Assessment of internal validity of echocardiographic, electrocardiographic and haemodynamic optimization of cardiac resynchronization therapy, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 167, Pages: 954-964, ISSN: 0167-5273

Journal article

Ploux S, Lumens J, Whinnett Z, Montaudon M, Strom M, Ramanathan C, Derval N, Zemmoura A, Denis A, De Guillebon M, Shah A, Hocini M, Jais P, Ritter P, Haissaguerre M, Wilkoff BL, Bordachar Pet al., 2013, Noninvasive Electrocardiographic Mapping to Improve Patient Selection for Cardiac Resynchronization Therapy Beyond QRS Duration and Left Bundle Branch Block Morphology, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 61, Pages: 2435-2443, ISSN: 0735-1097

Journal article

Bordachar P, Whinnett Z, Ploux S, Labrousse L, Haissaguerre M, Thambo J-Bet al., 2013, Pathophysiology, clinical course, and management of congenital complete atrioventricular block, HEART RHYTHM, Vol: 10, Pages: 760-766, ISSN: 1547-5271

Journal article

van Geldorp IE, Bordachar P, Lumens J, de Guillebon M, Whinnett ZI, Prinzen FW, Haissaguerre M, Delhaas T, Thambo J-Bet al., 2013, Acute hemodynamic benefits of biventricular and single-site systemic ventricular pacing in patients with a systemic right ventricle, HEART RHYTHM, Vol: 10, Pages: 676-682, ISSN: 1547-5271

Journal article

Barakat MF, Chehab O, Hayat S, Kelshiker M, Turner H, Norrington K, Konstantinou K, Whinnett Z, Koa-Wing M, Manisty C, Wright I, Jamil-Copley S, Lim B, Sutaria N, Nihoyannopoulos P, Lefroy D, Mayet J, Francis DP, Davies DW, Peters N, Kanagaratnam P, Okonko DOet al., 2013, ATTENUATIONS IN TISSUE DOPPLER-DERIVED LEFT VENTRICULAR SYSTOLIC VELOCITY PREDICT AN AMPLIFIED RISK OF LETHAL ARRHYTHMIAS IN ICD RECIPIENTS INDEPENDENTLY OF EJECTION FRACTION, 62nd Annual Scientific Session of the American-College-of-Cardiology, Publisher: ELSEVIER SCIENCE INC, Pages: E818-E818, ISSN: 0735-1097

Conference paper

Whinnett ZI, Francis DP, Denis A, Willson K, Pascale P, van Geldorp I, De Guillebon M, Ploux S, Ellenbogen K, Haissaguerre M, Ritter P, Bordachar Pet al., 2013, Comparison of different invasive hemodynamic methods for AV delay optimization in patients with cardiac resynchronization therapy: Implications for clinical trial design and clinical practice, International Journal of Cardiology, Vol: 168, Pages: 2228-2237, ISSN: 1874-1754

Journal article

Hayat SA, Kojodjojo P, Mason A, Benfield A, Wright I, Whinnett Z, Lim PB, Davies DW, Lefroy D, Peters NS, Kanagaratnam Pet al., 2013, Malfunction of Subpectorally Implanted Cardiac Resynchronization Therapy Defibrillators Due to Weakened Header Bond, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Vol: 24, Pages: 351-355, ISSN: 1045-3873

Journal article

Kyriacou A, Whinnett ZI, Davies JE, Pabari PA, Peters NS, Kanagaratnam P, Mayet J, Hughes AD, Francis DPet al., 2013, First-in-man evidence of the mechanistic effects of biventricular pacing on coronary physiology, Spring Meeting for Clinician Scientists in Training, Publisher: ELSEVIER SCIENCE INC, Pages: 62-62, ISSN: 0140-6736

Conference paper

Malcolme-Lawes LC, Lim PB, Koa-Wing M, Whinnett ZI, Jamil-Copley S, Hayat S, Francis DP, Kojodjojo P, Davies DW, Peters NS, Kanagaratnam Pet al., 2013, Robotic assistance and general anaesthesia improve catheter stability and increase signal attenuation during atrial fibrillation ablation, EUROPACE, Vol: 15, Pages: 41-47, ISSN: 1099-5129

Journal article

Mielewczik M, Cole GD, Nowbar AN, Schilling R, Whinnett ZI, Bordachar P, Wilmshurst P, Chambers JC, Olshansky B, Morgan J, otherset al., 2013, The C-CURE Randomized Clinical Trial (Cardiopoietic stem Cell therapy in heart failURE), Journal of the American College of Cardiology, Vol: 62, Pages: 2453-2453

Journal article

Whinnett ZI, Sohaib SMA, Davies DW, 2012, Diagnosis and management of supraventricular tachycardia, BMJ-BRITISH MEDICAL JOURNAL, Vol: 345, ISSN: 1756-1833

Journal article

Kyriacou A, Whinnett ZI, Sen S, Pabari PA, Wright I, Cornelussen R, Lefroy D, Davies DW, Peters NS, Kanagaratnam P, Mayet J, Hughes AD, Francis DP, Davies JEet al., 2012, Improvement in Coronary Blood Flow Velocity With Acute Biventricular Pacing Is Predominantly Due to an Increase in a Diastolic Backward-Travelling Decompression (Suction) Wave, CIRCULATION, Vol: 126, Pages: 1334-+, ISSN: 0009-7322

Journal article

Davies JE, Alastruey J, Francis DP, Hadjiloizou N, Whinnett ZI, Manisty CH, Aguado-Sierra J, Willson K, Foale RA, Malik IS, Hughes AD, Parker KH, Mayet Jet al., 2012, Attenuation of Wave Reflection by Wave Entrapment Creates a "Horizon Effect" in the Human Aorta, HYPERTENSION, Vol: 60, Pages: 778-+, ISSN: 0194-911X

Journal article

Sohaib SMA, Chen ZC, Whinnett Z, Francis DP, Manisty Cet al., 2012, Systematic review of genuine symptomatic response to cardiac resynchronization therapy: acknowledging the contribution of spontaneous response, Congress of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 995-995, ISSN: 0195-668X

Conference paper

Ploux S, Whinnett Z, Lumens J, Denis A, Zemmoura A, De Guillebon M, Ramoul K, Ritter P, Jaïs P, Clementy J, Haïssaguerre M, Bordachar Pet al., 2012, Acute hemodynamic response to biventricular pacing in heart failure patients with narrow, moderately, and severely prolonged QRS duration, Heart Rhythm, Vol: 9, Pages: 1247-1250, ISSN: 1547-5271

Journal article

Kyriacou A, Pabari PA, Whinnett ZI, Arri S, Willson K, Baruah R, Stegemann B, Mayet J, Kanagaratnam P, Hughes AD, Francis DPet al., 2012, Fully Automatable, Reproducible, Noninvasive Simple Plethysmographic Optimization: Proof of Concept and Potential for Implantability, PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, Vol: 35, Pages: 948-960, ISSN: 0147-8389

Journal article

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