Publications
212 results found
Whinnett ZI, Briscoe C, Davies JE, et al., 2008, The atrioventricular delay of cardiac resynchronization can be optimized hemodynamically during exercise and predicted from resting measurements., Heart Rhythm, Vol: 5, Pages: 378-386, ISSN: 1547-5271
Atrioventricular (AV) optimization of cardiac resynchronization therapy (CRT) is typically calculated at rest. However, patients often become symptomatic during exercise.
Manisty C, Willson K, Davies JE, et al., 2007, Cardiac output manipulation using pacemakers to dynamically modulate ventilation: a new potential therapeutic avenue for periodic breathing in heart failure, EUROPEAN HEART JOURNAL, Vol: 28, Pages: 872-872, ISSN: 0195-668X
Hadjiloizou N, Davies JE, Manisty CH, et al., 2007, Physiological mechansims underlying the differences in flow velocity in the left and right coronary arteries, EUROPEAN HEART JOURNAL, Vol: 28, Pages: 753-753, ISSN: 0195-668X
Manisty C, Willson K, Hadjiloizou N, et al., 2007, Chemoreflex gain: a physiological reflex without adaptation?, EUROPEAN HEART JOURNAL, Vol: 28, Pages: 873-873, ISSN: 0195-668X
Davies J, Hadjiloizou N, Manisty C, et al., 2007, A unifying explanation of the arterial pulse waveform in humans and the implications for central blood pressure augmentation, Annual Scientific Conference of the British-Cardiovascular-Society, Publisher: B M J PUBLISHING GROUP, Pages: A79-A80, ISSN: 1355-6037
Manisty C, Davies J, Whinnett Z, et al., 2007, Differences in the magnitude rather than the timing of wave reflection can explain the ASCOT results, Annual Scientific Conference of the British-Cardiovascular-Society, Publisher: B M J PUBLISHING GROUP, Pages: A80-A80, ISSN: 1355-6037
Raphael C, Briscoe C, Davies J, et al., 2007, Limitations of the New York Heart Association functional classification system and self-reported walking distances in chronic heart failure, HEART, Vol: 93, Pages: 476-482, ISSN: 1355-6037
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- Citations: 293
Davies JE, Hadjiloizou N, Leibovich D, et al., 2007, Importance of the aortic reservoir in determining the shape of the arterial pressure waveform - The forgotten lessons of Frank, Artery Research, Vol: 1, Pages: 40-45
It has been recognised for nearly 200 years that the human pressure waveform changes in shape with ageing and disease. The shape of the pressure waveform has been explained in terms of two fundamental models: the Windkessel (reservoir) and wave theory. In its simplest form the Windkessel model satisfactorily explains the pressure waveform in diastole but cannot model pressure changes in systole. Wave theory satisfactorily models the pressure waveform but predicts the existence of ‘self-cancelling’ forward and backward waves in diastole which are difficult to explain in biological terms. We propose that a hybrid reservoir–wave model better describes the pressure waveform and may enable assessment of aortic function from pressure measurements made at any large systemic artery.
Manisty CH, Willson K, Wensel R, et al., 2006, Apnoeic threshold: A true determinant of cardiorespiratory control stability or a marker of chemoreflex gain?, Winter Meeting of the British-Thoracic-Society/British-Lung-Foundation (BTS/BLF), Publisher: B M J PUBLISHING GROUP, Pages: II48-II49, ISSN: 0040-6376
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- Citations: 1
Manisty CH, Willson K, Davies JE, et al., 2006, Can cardiac pacemakers directly control ventilation?, Winter Meeting of the British-Thoracic-Society/British-Lung-Foundation (BTS/BLF), Publisher: B M J PUBLISHING GROUP, Pages: II49-II49, ISSN: 0040-6376
Manisty CH, Willson K, Wensel R, et al., 2006, Development of respiratory control instability in heart failure: a novel approach to dissect the pathophysiological mechanisms, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 577, Pages: 387-401, ISSN: 0022-3751
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- Citations: 24
Whinnett ZI, Davies JER, Willson K, et al., 2006, Haemodynamic effects of changes in atrioventricular and interventricular delay in cardiac resynchronisation therapy show a consistent pattern: Analysis of shape, magnitude and relative importance of atrioventricular and interventricular delay, HEART, Vol: 92, Pages: 1628-1634, ISSN: 1355-6037
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- Citations: 96
Davies JC, Francis DP, Whinnett ZI, et al., 2006, Coronary Microcirculation Suction Wave is Reduced in Left Ventricular Hypertrophy: A Novel Assessment Using Wave Intensity Analysis, 79th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 368-369, ISSN: 0009-7322
Manisty CH, Davies JE, Zambanini A, et al., 2006, Differential arterial wave reflection in ASCOT: An explanation for the results?, 79th Annual Scientific Session of the American-Heart-Association, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 537-537, ISSN: 0009-7322
Whinnett ZI, Davies JER, Briscoe KA, et al., 2006, Optimisation of the atrioventricular delay of cardiac resynchronisation determined during exercise can be predicted by a resting pacing model, 28th Congress of the European-Society-of-Cardiology/World Congress of Cardiology, Publisher: OXFORD UNIV PRESS, Pages: 193-193, ISSN: 0195-668X
Davies JE, Hadjiloizou N, Whinnett ZI, et al., 2006, Evidence to support the augmentation of coronary blood flow in systole, by wave reflection from the aorta, 28th Congress of the European-Society-of-Cardiology/World Congress of Cardiology, Publisher: OXFORD UNIV PRESS, Pages: 512-512, ISSN: 0195-668X
Manisty C, Davies J, Willson K, et al., 2006, Harnessing physiological cardiorespiratory interaction to modulate ventilation by dynamic changes in cardiac output, Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health, Publisher: B M J PUBLISHING GROUP, Pages: A39-A40, ISSN: 1355-6037
Davies J, Whinnett Z, Francis D, et al., 2006, Evidence of a dominant backward-propagating "suction" wave, responsible for diastolic coronary filling in humans, attenuated in left ventricular hypertrophy, Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health, Publisher: B M J PUBLISHING GROUP, Pages: A2-A3, ISSN: 1355-6037
Whinnett Z, Davies J, Briscoe C, et al., 2006, By pacing at increased rates at rest it is possible to predict the haemodynamic optimal atrioventricular delay of biventricular pacing determined during exercise, Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health, Publisher: B M J PUBLISHING GROUP, Pages: A113-A114, ISSN: 1355-6037
Davies J, Whinnett Z, Francis D, et al., 2006, Coronary blood flow is not augmented by aortic wave reflection: An invasive assessment using wave intensity analysis, Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health, Publisher: B M J PUBLISHING GROUP, Pages: A35-A35, ISSN: 1355-6037
Whinnett ZI, Davies JER, Willson K, et al., 2006, Determination of optimal atrioventricular delay for cardiac resynchronization therapy using acute non-invasive blood pressure, EUROPACE, Vol: 8, Pages: 358-366, ISSN: 1099-5129
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- Citations: 73
Manisty C, Davies J, Whinnett Z, et al., 2006, The role of wave reflection in the pathophysiology of hypertension: Assessed using non-invasive wave intensity analysis, Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health, Publisher: B M J PUBLISHING GROUP, Pages: A33-A33, ISSN: 1355-6037
Whinnett Z, Davies J, Willson K, et al., 2006, Changes in atrioventricular delay of cardiac resynchronisation therapy have a significantly larger haemodynamic effect compared with altering interventricular delay, Annual Scientific Conference of the British-Society-Promoting-Cardiovascular-Health, Publisher: B M J PUBLISHING GROUP, Pages: A114-A115, ISSN: 1355-6037
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- Citations: 2
Davies JE, Whinnett ZI, Francis DP, et al., 2006, Evidence of a dominant backward-propagating "suction" wave responsible for diastolic coronary filling in humans, attenuated in left ventricular hypertrophy, CIRCULATION, Vol: 113, Pages: 1768-1778, ISSN: 0009-7322
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- Citations: 299
Whinnett ZI, Davies JER, Willson K, et al., 2006, The haemodynamic response to changes in atrioventricular and interventricular delay of cardiac resynchronization therapy closely fits a parabola, which may allow more efficient optimization, 55th Annual Scientific Session of the American-College-of-Cardiology, Publisher: ELSEVIER SCIENCE INC, Pages: 22A-22A, ISSN: 0735-1097
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- Citations: 1
Davies JE, Whinnett ZI, Francis DP, et al., 2006, Use of simultaneous pressure and velocity measurements to estimate arterial wave speed at a single site in humans, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol: 290, Pages: H878-H885, ISSN: 0363-6135
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- Citations: 116
Davies JE, Hadjiloizou N, Whinnett ZI, et al., 2006, "The push me pull you" of coronary haemodynamics, 5th World Congress of Biomechanics/World Council of Biomechanics, Publisher: MEDIMOND S R L, Pages: 425-+
Whinnett ZI, Davies JER, Lane RE, et al., 2005, Echocardiographic methods for selecting patients suitable for biventricular pacing therapy., Minerva Cardioangiol, Vol: 53, Pages: 211-220, ISSN: 0026-4725
The large outcome studies of biventricular pacing to date have selected patients using electrocardiogram criteria (prolonged QRS and left bundle branch block morphology). However, 20-30% of patients do not appear to respond clinically, and as a result there has been much interest in developing more specific methods of detecting mechanical dyssynchrony. A number of different echocardiographic techniques have been developed which appear to offer greater sensitivity and specificity than ECG in selecting these patients. This paper reviews the most promising of the echocardiographic techniques and gives guidance for the clinical use of echocardiography in selecting patients for biventricular pacing.
Davies J, Whinnett Z, Francis D, et al., 2005, Effect of nitrate administration on wave speed propagation in the human coronary artery, Annual Conference of G-MEX/MICC, Publisher: B M J PUBLISHING GROUP, Pages: A66-A67, ISSN: 1355-6037
Whinnett Z, Davies J, Willson K, et al., 2005, Optimisation of atrioventricular (AV) and interventricular (VV) delay in biventricular pacing using continuous non-invasive measurement of blood pressure (BP), Annual Conference of G-MEX/MICC, Publisher: B M J PUBLISHING GROUP, Pages: A52-A53, ISSN: 1355-6037
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