Summary
I joined the section of Biomolecular Medicine at Imperial, in 2019, as a Lecturer in Lipid Metabolism & Signalling. Prior to this, I carried out my PhD at the University of Oxford and held post-doctoral appointments at the London School of Hygiene and Tropical Medicine (2013-2014) and the University of Cambridge (2014-2019).
My research interests lie at the intersection of mass spectrometry imaging, lipid metabolism and spatial systems biology, and fall broadly into the following themes:
- Spatial (dis)organisation in liver injury, repair and cancer
- Mapping cancer metabolism in time and space
- Tools and method development for spatial systems biology
Selected Publications
Journal Articles
Paterson HAB, Yu S, Artigas N, et al. , 2022, Liver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice, Nature Metabolism, Vol:4, ISSN:2522-5812, Pages:1812-1829
Belenguer G, Mastrogiovanni G, Pacini C, et al. , 2022, RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state., Nature Communications, Vol:13, ISSN:2041-1723, Pages:1-18
Newberry E, Hall ZL, Yan X, et al. , 2021, Liver specific deletion of mouse Tm6sf2 promotes steatosis, fibrosis and hepatocellular cancer, Hepatology, Vol:74, ISSN:0270-9139, Pages:1203-1219
Azzu V, Vacca M, Kamzolas I, et al. , 2021, Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression, Molecular Metabolism, Vol:48, ISSN:2212-8778, Pages:1-10
Hall Z, Chiarugi D, Charidemou E, et al. , 2021, Lipid remodelling in hepatocyte proliferation and hepatocellular carcinoma, Hepatology, Vol:73, ISSN:0270-9139, Pages:1028-1044
Bianchi A, Marchetti L, Hall Z, et al. , 2021, Moderate exercise inhibits age-related inflammation, liver steatosis, senescence, and tumorigenesis., Journal of Immunology, Vol:206, ISSN:0022-1767, Pages:904-916
Hall Z, Wilson CH, Burkhart DL, et al. , 2020, Myc linked to dysregulation of cholesterol transport and storage in non-small cell lung cancer., Journal of Lipid Research, Vol:61, ISSN:0022-2275, Pages:1390-1399
Bond NJ, Koulman A, Griffin JL, et al. , 2017, massPix: an R package for annotation and interpretation of mass spectrometry imaging data for lipidomics, Metabolomics, Vol:13, ISSN:1573-3882
Hall Z, Chu Y, Griffin JL, 2017, Liquid extraction surface analysis mass spectrometry method for identifying the presence and severity of nonalcoholic fatty liver disease, Analytical Chemistry, Vol:89, ISSN:0003-2700, Pages:5161-5170
Hall Z, Bond NJ, Ashmore T, et al. , 2017, Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease, Hepatology, Vol:65, ISSN:0270-9139, Pages:1165-1180
Hall Z, Ament Z, Wilson CH, et al. , 2016, Myc expression drives aberrant lipid metabolism in lung cancer, Cancer Research, Vol:76, ISSN:1538-7445, Pages:4608-4618