Imperial College London
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Dr Zulma M Cucunubá

Faculty of Medicine, School of Public Health

Honorary Lecturer
 
 
 
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Contact

 

zulma.cucunuba

 
 
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Location

 

G27Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Carrera:2020:10.4269/ajtmh.20-0408,
author = {Carrera, J-P and Cucunubá, ZM and Neira, K and Lambert, B and Pittí, Y and Liscano, J and Garzón, JL and Beltran, D and Collado-Mariscal, L and Saenz, L and Sosa, N and Rodriguez-Guzman, LD and González, P and Lezcano, AG and Pereyra-Elías, R and Valderrama, A and Weaver, SC and Vittor, AY and Armién, B and Pascale, J-M and Donnelly, CA},
doi = {10.4269/ajtmh.20-0408},
journal = {American Journal of Tropical Medicine and Hygiene},
pages = {2429--2437},
title = {Endemic and epidemic human alphavirus infections in eastern Panama: an analysis of population-based cross-sectional surveys.},
url = {http://dx.doi.org/10.4269/ajtmh.20-0408},
volume = {103},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Madariaga virus (MADV) has recently been associated with severe human disease in Panama, where the closely related Venezuelan equine encephalitis virus (VEEV) also circulates. In June 2017, a fatal MADV infection was confirmed in a community of Darien Province. We conducted a cross-sectional outbreak investigation with human and mosquito collections in July 2017, where sera were tested for alphavirus antibodies and viral RNA. In addition, by applying a catalytic, force-of-infection (FOI) statistical model to two serosurveys from Darien Province in 2012 and 2017, we investigated whether endemic or epidemic alphavirus transmission occurred historically. In 2017, MADV and VEEV IgM seroprevalences were 1.6% and 4.4%, respectively; IgG antibody prevalences were MADV: 13.2%, VEEV: 16.8%, Una virus (UNAV): 16.0%, and Mayaro virus: 1.1%. Active viral circulation was not detected. Evidence of MADV and UNAV infection was found near households, raising questions about its vectors and enzootic transmission cycles. Insomnia was associated with MADV and VEEV infections, depression symptoms were associated with MADV, and dizziness with VEEV and UNAV. Force-of-infection analyses suggest endemic alphavirus transmission historically, with recent increased human exposure to MADV and VEEV in Aruza and Mercadeo, respectively. The lack of additional neurological cases suggests that severe MADV and VEEV infections occur only rarely. Our results indicate that over the past five decades, alphavirus infections have occurred at low levels in eastern Panama, but that MADV and VEEV infections have recently increased-potentially during the past decade. Endemic infections and outbreaks of MADV and VEEV appear to differ spatially in some locations of eastern Panama.
AU  - Carrera,J-P
AU  - Cucunubá,ZM
AU  - Neira,K
AU  - Lambert,B
AU  - Pittí,Y
AU  - Liscano,J
AU  - Garzón,JL
AU  - Beltran,D
AU  - Collado-Mariscal,L
AU  - Saenz,L
AU  - Sosa,N
AU  - Rodriguez-Guzman,LD
AU  - González,P
AU  - Lezcano,AG
AU  - Pereyra-Elías,R
AU  - Valderrama,A
AU  - Weaver,SC
AU  - Vittor,AY
AU  - Armién,B
AU  - Pascale,J-M
AU  - Donnelly,CA
DO  - 10.4269/ajtmh.20-0408
EP  - 2437
PY  - 2020///
SN  - 0002-9637
SP  - 2429
TI  - Endemic and epidemic human alphavirus infections in eastern Panama: an analysis of population-based cross-sectional surveys.
T2  - American Journal of Tropical Medicine and Hygiene
UR  - http://dx.doi.org/10.4269/ajtmh.20-0408
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33124532
UR  - http://www.ajtmh.org/content/journals/10.4269/ajtmh.20-0408
UR  - http://hdl.handle.net/10044/1/84062
VL  - 103
ER  -
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