@inbook{Montaldo:2015,
author = {Montaldo, P and Montaldo, L and Chaban, B and Thayyil, S},
booktitle = {Asphyxia: Risk Factors, Prevalence and Neurological Impacts},
pages = {55--72},
title = {Perinatal infection as risk factor of neonatal encephalopathy},
year = {2015}
}

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TY  - CHAP
AB  - Fetal exposure to inflammation and infection has been shown to increase brain vulnerability to hypoxia-ischemia via stimulation of immune and inflammatory responses, chemotaxis, toll-like receptors and cell death. Perinatal infection is a potentially modifiable, risk factor for encephalopathy that has been linked to adverse outcomes. Nevertheless, the exact role of perinatal infection among neonates with a history of encephalopathy, is not yet completely understood. Emerging experimental data suggest that hypothermia may not be neuroprotective after a bacterial lipopolysaccharide-sensitized encephalopathy brain injury whereas it can be neuroprotective if a bacterial lipopolysaccharide-sensitized encephalopathy is not present. Hence, therapeutic hypothermia in the presence of infection might even be deleterious as hypothermia may impair innate immune function, including neutrophil migration and function. This chapter aims to discuss how an infective insult can affect the vulnerability of the neonatal brain to the hypoxic damage. We review whether newborns with encephalopathy and signs of neonatal sepsis are associated with a higher risk of neonatal brain injury and worse long-term neurodevelopmental outcome. Finally, we highlight new therapeutic strategies in this scenario.
AU  - Montaldo,P
AU  - Montaldo,L
AU  - Chaban,B
AU  - Thayyil,S
EP  - 72
PY  - 2015///
SN  - 9781634822251
SP  - 55
TI  - Perinatal infection as risk factor of neonatal encephalopathy
T1  - Asphyxia: Risk Factors, Prevalence and Neurological Impacts
ER  - 

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