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• Journal article
  NUTT D, 1988,

  BENZODIAZEPINE TERMINOLOGY

  , TRENDS IN PHARMACOLOGICAL SCIENCES, Vol: 9, Pages: 86-86, ISSN: 0165-6147
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• Journal article
  NUTT D, GLUE P, MOLYNEUX S, CLARK Eet al., 1988,

  ALPHA-2-ADRENOCEPTOR FUNCTION IN ALCOHOL WITHDRAWAL - A PILOT-STUDY OF THE EFFECTS OF IV-CLONIDINE IN ALCOHOLICS AND NORMALS

  , ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH, Vol: 12, Pages: 14-18
  • Cite
  • Citations: 54
• Journal article
  GLEITER CH, THIAGARAJAN AB, NUTT DJ, 1988,

  AN ANIMAL-MODEL FOR THE CNS ACTIONS OF ELECTRO-CONVULSIVE SHOCK (ECS)

  , CLINICAL PHARMACOLOGY & THERAPEUTICS, Vol: 43, Pages: 177-177, ISSN: 0009-9236
  • Author Web Link
  • Cite
• Journal article
  LISTER RG, NUTT DJ, 1988,

  INTERACTIONS OF THE IMIDAZODIAZEPINE RO-15-4513 WITH CHEMICAL CONVULSANTS

  , BRITISH JOURNAL OF PHARMACOLOGY, Vol: 93, Pages: 210-214, ISSN: 0007-1188
  • Cite
  • Citations: 41
• Journal article
  GLEITER CH, DECKERT J, NUTT DJ, 1988,

  CHANGES IN CAFFEINE SEIZURE THRESHOLD AFTER ELECTROCONVULSIVE SHOCK

  , PSYCHOPHARMACOLOGY, Vol: 95, Pages: 544-545, ISSN: 0033-3158
  • Author Web Link
  • Cite
  • Citations: 3
• Journal article
  THIAGARAJAN AB, GLEITER CH, NUTT DJ, 1988,

  ELECTROCONVULSIVE SHOCK DOES NOT INCREASE PLASMA-INSULIN IN RATS

  , CONVULSIVE THERAPY, Vol: 4, Pages: 292-296, ISSN: 0749-8055
  • Author Web Link
  • Cite
  • Citations: 7
• Journal article
  Risher-Flowers D, Adinoff B, Ravitz B, Bone GH, Martin PR, Nutt D, Linnoila Met al., 1988,

  Circadian rhythms of cortisol during alcohol withdrawal.

  , Adv Alcohol Subst Abuse, Vol: 7, Pages: 37-41, ISSN: 0270-3106

  The authors have investigated the function of the hypothalamic-pituitary-adrenocortical (HPA) axis during and after withdrawal from alcohol. 24 hour rhythms of cortisol were abnormal in that elevated levels were seen throughout the day in patients with moderate to severe, but not mild, withdrawal. This abnormality of circadian secretion of cortisol, which is similar to that seen in Cushing's syndrome and post-operative trauma, returned to normal after a period of one week of abstinence on their in-patient ward. Such excessive secretion of cortisol may explain some of the complications of chronic alcoholism.

  • Abstract
  • Author Web Link
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• Journal article
  Lister RG, Nutt DJ, 1988,

  RO 15-4513 and its interaction with ethanol.

  , Adv Alcohol Subst Abuse, Vol: 7, Pages: 119-123, ISSN: 0270-3106

  It has recently been claimed that RO 15-4513 selectively opposes some of the behavioral actions of ethanol. Our studies on the intrinsic effects of this compound have shown it to be proconvulsant and to reduce exploratory behavior in mice. In these respects RO 15-4513 resembles a benzodiazepine receptor partial inverse agonist. Such intrinsic actions may well explain its alcohol-antagonizing properties, and argue against its potential in humans. In addition to partially reversing the effects of ethanol, RO 15-4513 also partially reverses the behavioral effect of a barbiturate and completely reverses the effects of a benzodiazepine.

  • Abstract
  • Author Web Link
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• Journal article
  GLEITER CH, NUTT DJ, 1988,

  A SINGLE ELECTROCONVULSIVE SHOCK SUBSTANTIALLY LOWERS BLOOD-GLUCOSE LEVELS IN OBESE MICE (C57BL/6J OB/OB)

  , PSYCHOPHARMACOLOGY, Vol: 95, Pages: 287-288, ISSN: 0033-3158
  • Author Web Link
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• Journal article
  NUTT DJ, TAYLOR SC, LITTLE HJ, STANDING BL, GALE RGet al., 1988,

  CHANGES IN BENZODIAZEPINE GABA RECEPTOR COMPLEX FUNCTION IN BENZODIAZEPINE-TOLERANT MICE

  , PSYCHOPHARMACOLOGY, Vol: 95, Pages: 407-412, ISSN: 0033-3158
  • Cite
  • Citations: 19

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