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  • Journal article
    Timmermann Slater CB, Bauer P, Gosseries O, Vanhaudenhuyse A, Vollenweider F, Laureys S, Singer T, Mind and Life MLE ENCECON Research Group, Antonova E, Lutz Aet al., 2023,

    A neurophenomenological approach to non-ordinary states of consciousness: hypnosis, meditation, and psychedelics

    , Trends in Cognitive Sciences, Vol: 27, Pages: 139-159, ISSN: 1364-6613

    No contemporary unifying framework has been provided for the study of non-ordinary states of consciousness (NSCs) despite increased interest in hypnosis, meditation, and psychedelics. NSCs induce shifts in experiential contents (what appears to the experiencer) and/or structure (how it appears). This can allow the investigation of the plastic and dynamic nature of experience from a multiscale perspective that includes mind, brain, body, and context. We propose a neurophenomenological (NP) approach to the study of NSCs which highlights their role as catalysts of transformation in clinical practice by refining our understanding of the relationships between experiential (subjective) and neural dynamics. We outline the ethical implications of the NP approach for standard conceptions of health and pathology as well as the crucial role of experience-based know-how in NSC-related research and application.

  • Journal article
    Luppi AI, Vohryzek J, Kringelbach ML, Mediano PAM, Craig MM, Adapa R, Carhart-Harris RL, Roseman L, Pappas I, Peattie ARD, Manktelow AE, Sahakian BJ, Finoia P, Williams GB, Allanson J, Pickard JD, Menon DK, Atasoy S, Stamatakis EAet al., 2023,

    Distributed harmonic patterns of structure-function dependence orchestrate human consciousness.

    , Commun Biol, Vol: 6

    A central question in neuroscience is how consciousness arises from the dynamic interplay of brain structure and function. Here we decompose functional MRI signals from pathological and pharmacologically-induced perturbations of consciousness into distributed patterns of structure-function dependence across scales: the harmonic modes of the human structural connectome. We show that structure-function coupling is a generalisable indicator of consciousness that is under bi-directional neuromodulatory control. We find increased structure-function coupling across scales during loss of consciousness, whether due to anaesthesia or brain injury, capable of discriminating between behaviourally indistinguishable sub-categories of brain-injured patients, tracking the presence of covert consciousness. The opposite harmonic signature characterises the altered state induced by LSD or ketamine, reflecting psychedelic-induced decoupling of brain function from structure and correlating with physiological and subjective scores. Overall, connectome harmonic decomposition reveals how neuromodulation and the network architecture of the human connectome jointly shape consciousness and distributed functional activation across scales.

  • Journal article
    Scagliarini T, Nuzzi D, Antonacci Y, Faes L, Rosas FE, Marinazzo D, Stramaglia Set al., 2023,

    Gradients of O-information: Low-order descriptors of high-order dependencies

    , Physical Review Research, Vol: 5, Pages: 1-8, ISSN: 2643-1564

    O-information is an information-theoretic metric that captures the overall balance between redundant and synergistic information shared by groups of three or more variables. To complement the global assessment provided by this metric, here we propose the gradients of the O-information as low-order descriptors that can characterize how high-order effects are localized across a system of interest. We illustrate the capabilities of the proposed framework by revealing the role of specific spins in Ising models with frustration, in Ising models with three-spin interactions, and in a linear vectorial autoregressive process. We also provide an example of practical data analysis on U.S. macroeconomic data. Our theoretical and empirical analyses demonstrate the potential of these gradients to highlight the contribution of variables in forming high-order informational circuits.

  • Journal article
    Zeifman R, Spriggs M, Kettner H, Lyons T, Rosas F, Mediano P, Erritzoe D, Carhart-Harris Ret al., 2023,

    From Relaxed Beliefs Under Psychedelics (REBUS) to Revised Beliefs After Psychedelics (REBAS)

    , Scientific Reports, ISSN: 2045-2322

    Objectives: This was a cross sectional study aimed at describing chest x-ray findings among children hospitalised with clinically diagnosed severe pneumonia and hypoxaemia (SpO2<92%) in three tertiary facilities in Uganda.Methods: We studied chest x-rays of 375 children aged 28 days to 12 years enrolled into the Children’s Oxygen Administration Strategies Trial (COAST)(ISRCTN15622505). Radiologists blinded to the clinical findings reported chest x-rays using the standardized World Health Organization methodology for paediatric chest Xray reporting. We summarised clinical data and chest x-ray findings using descriptive statistics. Chi-square and proportion tests were used to compare proportions and quantile regression compared medians. Results: We found 172, (45.8%) children had radiological pneumonia, 136 (36.3%) normal chest radiographs while 123 (32.8%) non-pneumonia findings, the major one being cardiovascular abnormalities,106 (28.3%); 56 (14.9%) chest radiographs had both pneumonia and other abnormalities. There was no difference in the prevalence of radiological pneumonia, cardiovascular abnormalities, and mortality between the group with severe hypoxaemia (SpO2<80%) and that with mild hypoxaemia (SpO280 to <92%), (95% CI: -13.2,7.1, -6.1,15.9) and -37.2, 20.4) respectively. Conclusion: This study highlights a relatively high prevalence of cardiovascular abnormalities in children who fulfill the WHO clinical criteria for severe pneumonia and have hypoxaemia. We recommend that chest x-ray examinations be routinely done for all children in this population because information concerning cardiovascular and respiratory systems can be obtained in one sitting and guide management better. We hope that these findings can prompt discussions into refining the clinical criteria used to classify and manage pneumonia in children in limited resource settings.

  • Journal article
    Cieri F, Carhart-Harris RL, Mathys C, Turnbull O, Solms Met al., 2023,

    Editorial: Frontiers in psychodynamic neuroscience

    , Frontiers in Human Neuroscience, Vol: 17
  • Journal article
    Dourron HM, Nichols CD, Simonsson O, Bradley M, Carhart-Harris R, Hendricks PSet al., 2023,

    5-MeO-DMT: An atypical psychedelic with unique pharmacology, phenomenology &amp; risk?

    , Psychopharmacology, ISSN: 0033-3158

    5-MeO-DMT is a tryptamine being developed as a potential antidepressant that may display a distinct therapeutic mechanism due to its unique pharmacology and subjective effects compared to typical psychedelics. In this article, we parallel the relatively distinct phenomenology and behavioral effects of the acute and post-acute effects of 5-MeO-DMT to those induced by epileptiform activity, particularly in instances within epileptogenic zones of the temporal lobes. This is done by reviewing aberrant 5-HT1A receptor functioning in epilepsy, noting that 5-MeO-DMT has notable 5-HT1A receptor agonist properties—and then comparing the acute behavioral and subjective effects induced by 5-MeO-DMT to those that occur in seizures. It might be that 5-MeO-DMT's therapeutic mechanism is partly mediated by evoking temporary epileptiform activity, suggesting a similarity to electroconvulsive therapy. It is also noted that “reactivations,” the sudden re-experiencing of drug effects common after 5-MeO-DMT but not after typical psychedelics, may suggest that 5-MeO-DMT produces recurrent epileptiform activity. Overall, this review indicates that further evaluation of 5-MeO-DMT's unique mechanisms in research settings and among naturalistic users are warranted.

  • Journal article
    Hadar A, David J, Shalit N, Roseman L, Gross R, Sessa B, Lev-Ran Set al., 2023,

    The Psychedelic Renaissance in Clinical Research: A Bibliometric Analysis of Three Decades of Human Studies with Classical Psychedelics

    , JOURNAL OF PSYCHOACTIVE DRUGS, Vol: 55, Pages: 1-10, ISSN: 0279-1072
  • Journal article
    Vamvakopoulou IA, Narine KAD, Campbell I, Dyck JRB, Nutt DJet al., 2023,

    Mescaline: The forgotten psychedelic*

    , NEUROPHARMACOLOGY, Vol: 222, ISSN: 0028-3908
  • Journal article
    Shukuroglou M, Roseman L, Wall M, Nutt D, Kaelen M, Carhart-Harris Ret al., 2023,

    Changes in music-evoked emotion and ventral striatal functional connectivity after psilocybin therapy for depression

    , JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 37, Pages: 70-79, ISSN: 0269-8811
  • Journal article
    Forstmann M, Kettner HS, Sagioglou C, Irvine A, Gandy S, Carhart-Harris RL, Luke Det al., 2023,

    Among psychedelic-experienced users, only past use of psilocybin reliably predicts nature relatedness

    , JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 37, Pages: 93-106, ISSN: 0269-8811

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