In this section
@article{Vohryzek:2022:rs.3.rs-2060381/v1,
author = {Vohryzek, J and Cabral, J and Lord, L-D and Fernandes, H and Roseman, L and Nutt, D and Carhart-Harris, R and Deco, G and Kringelbach, M},
doi = {rs.3.rs-2060381/v1},
title = {Brain dynamics predictive of response to psilocybin for treatment-resistant depression},
url = {http://dx.doi.org/10.21203/rs.3.rs-2060381/v1},
year = {2022}
}
TY - JOUR
AB - <title>Abstract</title> <p>Psilocybin therapy for depression has started to show promise, yet the underlying causal mechanisms are not currently known. Here we leveraged the differential outcome in responders and non-responders to psilocybin (10mg and 25mg, 7 days apart) therapy for depression - to gain new insights into regions and networks implicated in the restoration of healthy brain dynamics. We used whole-brain modelling to fit the spatiotemporal brain dynamics at rest in both responders and non-responders before treatment. Dynamic sensitivity analysis of systematic perturbation of these models enabled us to identify specific brain regions implicated in a transition from a depressive brain state to a heathy one. Binarizing the sample into treatment responders (> 50% reduction in depressive symptoms) versus non-responders enabled us to identify a subset of regions implicated in this change. Interestingly, these regions correlate with in vivo density maps of serotonin receptors 5-HT<sub>2A</sub> and 5-HT<sub>1A</sub>, which psilocin, the active metabolite of psilocybin, has an appreciable affinity for, and where it acts as a full-to-partial agonist. Serotonergic transmission has long been associated with depression and our findings provide causal mechanistic evidence for the role of brain regions in the recovery from depression via psilocybin.</p>
AU - Vohryzek,J
AU - Cabral,J
AU - Lord,L-D
AU - Fernandes,H
AU - Roseman,L
AU - Nutt,D
AU - Carhart-Harris,R
AU - Deco,G
AU - Kringelbach,M
DO - rs.3.rs-2060381/v1
PY - 2022///
TI - Brain dynamics predictive of response to psilocybin for treatment-resistant depression
UR - http://dx.doi.org/10.21203/rs.3.rs-2060381/v1
UR - https://doi.org/10.21203/rs.3.rs-2060381/v1
ER -
