Citation

BibTex format

@article{Weiss:2024:10.1017/S0033291723001514,
author = {Weiss, B and Ginige, I and Shannon, L and Giribaldi, B and Murphy-Beiner, A and Murphy, R and Baker-Jones, M and Martell, J and Nutt, DJ and Carhart-Harris, RL and Erritzoe, D},
doi = {10.1017/S0033291723001514},
journal = {Psychological Medicine},
pages = {178--192},
title = {Personality change in a trial of psilocybin therapy vs escitalopram treatment for depression},
url = {http://dx.doi.org/10.1017/S0033291723001514},
volume = {54},
year = {2024}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Background:Psilocybin Therapy (PT) is being increasingly studied as a psychiatric intervention. Personality relates to mental health and can be used to probe the nature of PT's therapeutic action.Methods:In a phase 2, double-blind, randomized, active comparator controlled trial involving patients with moderate-to-severe major depressive disorder, we compared psilocybin with escitalopram, over a core 6-week trial period. Five-Factor model personality domains, Big Five Aspect Scale Openness aspects, Absorption, and Impulsivity were measured at Baseline, Week 6, and Month 6 follow-up.Results:PT was associated with decreases in neuroticism (B = −0.63), introversion (B = −0.38), disagreeableness (B = −0.47), impulsivity (B = −0.40), and increases in absorption (B = 0.32), conscientiousness (B = 0.30), and openness (B = 0.23) at week 6, with neuroticism (B = −0.47) and disagreeableness (B = −0.41) remaining decreased at month 6. Escitalopram Treatment (ET) was associated with decreases in neuroticism (B = −0.38), disagreeableness (B = −0.26), impulsivity (B = −0.35), and increases in openness (B = 0.28) at week 6, with neuroticism (B = −0.46) remaining decreased at month 6. No significant between-condition differences were observed.Conclusions:Personality changes across both conditions were in a direction consistent with improved mental health. With the possible exception of trait absorption, there were no compelling between-condition differences warranting conclusions regarding a selective action of PT (v. ET) on personality; however, post-ET changes in personality were significantly moderated by pre-trial positive expectancy for escitalopram, whereas expectancy did not moderate response to PT.
AU - Weiss,B
AU - Ginige,I
AU - Shannon,L
AU - Giribaldi,B
AU - Murphy-Beiner,A
AU - Murphy,R
AU - Baker-Jones,M
AU - Martell,J
AU - Nutt,DJ
AU - Carhart-Harris,RL
AU - Erritzoe,D
DO - 10.1017/S0033291723001514
EP - 192
PY - 2024///
SN - 0033-2917
SP - 178
TI - Personality change in a trial of psilocybin therapy vs escitalopram treatment for depression
T2 - Psychological Medicine
UR - http://dx.doi.org/10.1017/S0033291723001514
UR - http://hdl.handle.net/10044/1/104385
VL - 54
ER -