In this section
@article{Piccinini:2025:10.1038/s42003-025-07576-0,
author = {Piccinini, JI and Sanz, Perl Y and Pallavicini, C and Deco, G and Kringelbach, M and Nutt, D and Carhart-Harris, R and Timmermann, C and Tagliazucchi, E},
doi = {10.1038/s42003-025-07576-0},
journal = {Commun Biol},
title = {Transient destabilization of whole brain dynamics induced by N,N-Dimethyltryptamine (DMT).},
url = {http://dx.doi.org/10.1038/s42003-025-07576-0},
volume = {8},
year = {2025}
}
TY - JOUR
AB - The transition towards the brain state induced by psychedelic drugs is frequently neglected in favor of a static description of their acute effects. We use a time-dependent whole-brain model to reproduce large-scale brain dynamics measured with fMRI from 15 volunteers under 20 mg intravenous N,N-Dimethyltryptamine (DMT), a short-acting psychedelic. To capture its transient effects, we parametrize the proximity to a global bifurcation using a pharmacokinetic equation. Simulated perturbations reveal a transient of heightened reactivity concentrated in fronto-parietal regions and visual cortices, correlated with serotonin 5HT2a receptor density, the primary target of psychedelics. These advances suggest a mechanism to explain key features of the psychedelic state and also predicts that the temporal evolution of these features aligns with pharmacokinetics. Our results contribute to understanding how psychedelics introduce a transient where minimal perturbations can achieve a maximal effect, shedding light on how short psychedelic episodes may extend an overarching influence over time.
AU - Piccinini,JI
AU - Sanz,Perl Y
AU - Pallavicini,C
AU - Deco,G
AU - Kringelbach,M
AU - Nutt,D
AU - Carhart-Harris,R
AU - Timmermann,C
AU - Tagliazucchi,E
DO - 10.1038/s42003-025-07576-0
PY - 2025///
TI - Transient destabilization of whole brain dynamics induced by N,N-Dimethyltryptamine (DMT).
T2 - Commun Biol
UR - http://dx.doi.org/10.1038/s42003-025-07576-0
UR - https://www.ncbi.nlm.nih.gov/pubmed/40069397
VL - 8
ER -
