the 3Rs Hub
To continue Imperial College’s drive towards becoming world-leader for its 3Rs activities, in 2021, the CBS department has created a new Hub for the 3Rs at Imperial College London. The primary aim of the Hub is to promote the 3Rs principles across the College and influence the College Culture of Care.
If you want to know more, please contact the Communications and 3Rs Programme manager, Dr Anna Napolitano.
3Rs initiatives widget
We have developed a series of training activities to help animal care staff and researchers continuously refine and improve their knowledge in applying 3Rs principles.
Introduction to the 3Rs for new starters
We offer a general introduction about 3Rs principles to all researcher and staff start working with animals at Imperial.
Experimental design and power analysis for in-vivo scientists
We run twice a year a course focused on using statistics and experimental design for in vivo studies.
We organize seminar series and dedicated workshops in collaboration with internal and external stakeholders.
We want to help to improve the internal and external visibility of the 3Rs activities that take place at Imperial. therefore we have established a series of initiatives to improve the reduction and refinement of the animal used in our facilities.
We have developed a systematic approach to sharing resources within College. We are implementing the current animal management software to allow researchers within the different campuses to share animal resources from the units they work within. This initiative will enable better use of the resources and implement a 3Rs approach to animals’ use.
Technician led projects
We work closely with the Environmental Enrichment Committee to scientifically and financially support 3Rs projects conceived from or involving CBS staff.
Examples of current President's PhD students with a 3Rs-oriented project
"My project aims to develop novel in vitro models of pulmonary arteries based on medical imaging and using 3D printing methods. Animal models of chronic thromboembolic pulmonary hypertension (CTEPH) are currently limited and do not fully replicate the pathobiology of the disease. My devices will be addressing these gaps, thus reducing the need for animal studies and providing a potential platform for personalised medicine". (Salina Nicoleau, Wojciak-Stothard Group - National Heart and Lung Institute)
"The aim of my work is to replace animal-derived antibodies in diagnostic and therapeutic applications with synthetic alternatives, in the form of molecularly imprinted polymer (MIP) nanoparticles. These plastic antibodies are low cost, easy to produce, highly customizable and require no animal-derived materials in order to achieve similar affinity and specificity to their natural counterparts". (Stanislav Piletsky, Spivey Group - Department of Chemistry)