Group II - Type II receptors

Human sequence alignment

Joint human/mouse sequence alignment

Introduction

 

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CYTOPLASMIC TAIL and TRANSMEMBRANE REGION

 

LSECtin                        MDTTRYSKWGGSSEEVPGGPWGRWVHWSRRPLFLALAVLVTTVLWAVILSILL

IgFcR                                   MEEGQYSEIEELPRRRCC—RRGTQIVLLGLVTAALWAGLLTLLLLWHW

Prolectin  GLDLAAVTCPPPQLAVNLEPSPLQPSLAATPVPWLNQRSGGPGCCQKRWMVYLCLLVVTSLFLGCLGLTVTLIKY

DC-SIGN        MSDSKEPRLQQLGLLEEE--------QLRGLGFRQTRGYKSLAGCLGHGPLVLQLLSFTLLAGLL----VQVS

DC-SIGNR       MSDSKEPRVQQLGLLEEDPTTSGIRLFPRDFQFQQIHGHKSSTGCLGHGALVLQLLSFMLLAGVLVAILVQVS

ASGPR-H1  MTKEYQDLQHLDNEESDHHQLR------------------KGPPPPQPLLQRLCSGPRLLLLSLGLSLLLLVVVCVIGS

ASGPR-H2  MAKDFQDIQQLSSEENDHPFHQGEGPGTRRLNPRRGNPFLKGPPPAQPLAQRLCSMVCFSLLALSFNILLLVVICVTGS

ASGPR-M   MTRTYENFQYLENKVKVQGFK-------------------NGPLPLQSLLQRLRSGPCHLLLSLGLGLLLLVIICVVGF

DCIR MT                  SEITYAEVRFKNEFKSSGINTASSAASKERTAPLKSNTGFPKLLCASLLIFFLLLAISFFIAFVIFF

Dectin-2                                         MMQEQQPQSTEKRGWLSLRLWSVAGISIALLSACFIVSCVV

Mincle                                       MNSSKSSETQCTERGCF-SSQMFLWTVAGIPILFLSACFITRCVVTF

BDCA-2                                          MVPEEEPQDREKGLWWFQLKVWSMAVVSILLLSVCFTVSSVV

CLEC-6                                           MGLEKPQSKLEGGMHPQLIPSVIAVVFILLLGVCFIASCLV

SRCL                          MKDDFAEEEEVQSFGYKRFGIQEGTQCTKCKNNWALKFSIILLYILCALLTITVAILGY

Langerin             MTVEKEAPDAHFTVDKQNISLWPREPPPKSGPSLVPGKTPTVRAALICLTLVLVASVLLQAVLYP

 

POTENTIAL INTERNALISATION SIGNAL     TRANSMEMBRANE DOMAIN

NECK REGION: COILED-COIL and COLLAGEN-LIKE DOMAINS

 

LSECtin   SKASTERAALLDGHDLLRTNASKQTAALGALKEEVGDCHSCCSGTQAQLQTTRAELGEAQAKLMEQESALRELRERVTQGLAEAGRGREDVRTELFRALEAVRLQN

IgFcR                               DTTQSLKQLEERAARNVSQVSKNLESHHGDQMAQKSQSTQ

ISQELEELRAEQQRLKSQDLE

LSWNLNGLQADLSSFKSQELNERNE

ASDLLERLREEVTKLRMELQVSSG

Prolectin  KYQELMEELRMLSFQQMTWRTNMTGMAGLAGLKHDIARVRADTNQSLVELWGLLDCRRITCPEGWLPL

 

DC-SIGN   KVPSSISQEQSRQDAIYQNLTQLKAAVGELSEKSKLQE

                         IYQELTQLKAAVGELPEKSKLQE

                         IYQELTRLKAAVGELPEKSKLQE

                         IYQELTWLKAAVGELPEKSKMQE

                         IYQELTRLKAAVGELPEKSKQQE

                         IYQELTRLKAAVGELPEKSKQQE

                         IYQELTRLKAAVGELPEK

DC-SIGNR  KVPSSLSQEQSEQDAIYQNLTQLKAAVGELSEKSKLQE

                         IYQELTQLKAAVGELPEKSKLQE

                         IYQELTRLKAAVGELPEKSKLQE

                         IYQELTRLKAAVGELPEKSKLQE

                         IYQELTRLKAAVGELPEKSKLQE

                         IYQELTELKAAVGELPEKSKLQE

                         IYQELTQLKAAVGELPDQSKQQQ

                         IYQELTDLKTAFE

 

 

ASGPR-H1  QN-----SQLQEELRGLRETFSNFTASTEAQVKGLSTQGGNVGRKMKSLESQLEKQQKDLSEDHSSLLLHVKQFVSDLRS

ASGPR-H2  QSEGHRGAQLQAELRSLKEAFSNFSSSTLTEVQAISTHGGSVGDKITSLGAKLEKQQQDLKADHDALLFHLKHFPVDLRF

ASGPR-M   QN-----SKFQRDLVTLRTDFSNFTSNTVAEIQALTSQGSSLEETIASLKAEVEGFKQERQAVHSEMLLR------------------------VQQLVQDLKK

                       

DCIR      QKYSQLLEKKTTKELVHTT

Dectin-2  TYHFTYGETGKRLSELHSYHSS

Mincle    RIFQTCDEKKFQLPENFTE

BDCA-2    PHNFMY SKTVKRLSKLREYQQYHPS

CLEC-6    THHNFSRCKRGTGVHKLEHHAK

 

SRCL        KVVEKMDNVTGGMETSRQTYDDKLTAVESDLKKLGDQTGKKAISTNSE

              LSTFRSDILDLRQQLREITEKTSKNKDT

              LEKLQASGDALVDRQSQLKETLENNSFLITTVNKTLQAYNGYVTNLQQDTSVLQGNLQNQMYSHNV

          VIMNLNNLNLTQVQQRNL

              ITNLQRSVDDTSQAIQRIKNDFQNLQQVFLQAKKDTDWLKEKVQSLQTLAANNSALAKANNDT

              LEDMNSQLNSFTGQMENITTISQANEQNLKDLQDLHKDAENRTAIK

              FNQLEERFQLFETDIVNIISNISYTAHHLRTLTSNLNEVRTTCTDTLTKHTDD

              LTSLNNTLANIRLDSVSLRMQQDLMRSR

          LDTEVANLSVIMEEMKLVDSKHGQL

              IKNFTILQ

 

SRCL      GPPGPRGPRGDRGSQGPPGPTGNKGQKGEKGEPGPPGPAGERGPIGPAGPPGERGGKGSKGSQGPKGSRGSPGKP

                GPQGPSGDPGPPGPPGKEGLPGPQGPPGFQGLQGTVGEPGVPGPRGLPGLPGVPGMPGPKGPPGPPGPSGAV

 

 

Langerin  RFMGTISDVKTNVQLLKGRVDNISTLDSEIKKNSDGMEAAGVQIQMVNESLGYVRSQFLKLKTSV

                EKANAQIQILTRSWEEVSTLNAQIPELKSDLEKASALNTKIRALQGSLENMSKLLKRQNDIL

 

 

Kupffer*  ANAEIQGLKENLQNTNALNSQTQAFIKSSFDNTSAEIQFLRGHLERAGDEIHVLKRDLKMVTAQTQKANGRLDQTDTQIQVFKSEMENVNT

                LNAQIQVLNGHMKNASREIQTLKQGMK-NASALTSQTQMLDSNLQKASAEIQRLRGDLENTKALTMEIQQEQSRLKTLHVVITSQEQLQRTQS

 

              HEPTAD REPEAT     COLLAGENOUS DOMAIN

CTLD - N-TERMINAL

 

LSECtin                   NSCEPCPTSWLSFEGSCYFFSVPKTT--WAAAQDHCADASAHLVIVGGLDEQGFLTRNT-RGRGY-WLGLRAVRHLGKVQ

IgFcR                     FVCNTCPEKWINFQRKCYYFGKGTKQ--WVHARYACDDMEGQLVSIHSPEEQDFLTKHASHTG--SWIGLRNLDLKG

Prolectin LDC--------------RRITCPEGWLPFEGKCYYFSPSTKS--WDEARMFCQENYSHLVIINSFAEHNFVAKAHGSPRV-YWLGLNDRAQEG

DC-SIGN                   RLCHPCPWEWTFFQGNCYFMSNSQRN--WHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEG

DC-SIGNR                  RLCRHCPKDWTFFQGNCYFMSNSQRN--WHDSVTACQEVRAQLVVIKTAEEQNFLQLQTSRSNRFSWMGLSDLNQEG

ASGPR-H1  LSCQMAALQGNG----SERTCCPVNWVEHERSCYWFSRSGKA--WADADNYCRLEDAHLVVVTSWEEQKFVQHHIGPVN--TWMGLHD--QNG

ASGPR-H2  VACQMELLHSNG----SQRTCCPVNWVEHQGSCYWFSHSGKA--WAEAEKYCQLENAHLVVINSWEEQKFIVQHTNPFN--TWIGLTD--SDG

ASGPR-M   LTCQVATLNNNGEEASTEGTCCPVNWVEHQDSCYWFSHSGMS--WAEAEKYCQLKNAHLVVINSREEQNFVQKYLGSAY--TWMGLSD--PEG

DCIR      LECVKKNM----PVEETAWSCCPKNWKSFSSNCYFISTESAS--WQDCEKDCARMEAHLLVINTQEEQDFIFQNLQEES-AYFVGLSDPEGQR

Dectin-2  LTCFSEGV----STKVPAWGCCPASWKSFGSSCYFISSEEKV--WSKSEQNCVEMGAHLVVFNTEAEQNFIVQQLNESF-SYFLGLSDPQGNN

Mincle    LSCYNYGS-------GSVKNCCPLNWEYFQSSCYFFSTDTIS--WALSLKNCSAMGAHLVVINSQEEQEFLSYKKPKMR-EFFIGLSDQVVEG

BDCA-2    LTCVMEGK------DIEDWSCCPTPWTSFQSSCYFISTGMQS--WTKSQKNCSVMGADLVVINTREEQDFIIQNLKRNS-SYFLGLSDPGGRR

CLEC-6    LKCIKEK-SELKSAEGSTWNCCPIDWRAFQSNCYFPLTDNKT--WAESERNCSGMGAHLMTISTEAEQNFIIQFLDRRL-SYFLGLRDENAKG

SRCL          VPLALQNEPTPAPEDNSCPPHWKNFTDKCYYFSVEKEI--FEDAKLFCEDKSSHLVFINTREEQQWIKKQMVGRE-SHWIGLTDSEREN

Langerin                     QVVSQGWKYFKGNFYYFSLIPKT--WYSAEQFCVSRNSHLTSVTSESEQEFLYKTAGGLI--YWIGLTKAGMEG

Kupffer                      QMVLQGWKFNGGSLYYFSSVKKS--WHEAEQFCVSQGAHLASVASKEEQAFLVEFTSKVY--YWIGLTDRGTEG

DC-SIGN                   RLCHPCPWEWTFFQGNCYFMSNSQRN--WHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEG

 

 

 

CTLD - C-TERMINAL

 

LSECtin                   GYQWVDGVSLSFS---------HWNQGEPND-----AWGRENCVMML-HTGL-----WNDAPCDSEKDGWICEKRHN-C
IgFcR                     EFIWVDGSHVDYS---------NWAPGEPTS-----RSQGEDCVMMR-GSGR-----WNDAFCDRKLGAWVCDRLAT-CTPPASEGSAESMGPDSRPDPDGRLPTPSAPLHS

Prolectin                 DWRWLDGSPVTLS---------FWEPEEPNN------IHDEDCATMNKGGT------WNDLSCYKTT-YWICER-KCSC

DC-SIGN                   TWQWVDGSPLLPSFKQ------YWNRGEPNN------VGEEDCAEFS-GNG------WNDDKCNLAK-FWICKKSAASCSRDEEQFLSPAPATPNPPPA

DC-SIGNR                  TWQWVDGSPLSPSFQR------YWNSGEPNN------SGNEDCAEFS-GSG------WNDNRCDVDN-YWICKKPAA-CFRDE

ASGPR-H1                  PWKWVDGTDYETGFK-------NWRPEQPDDWYGHGLGGGEDCAHFT-DDGR-----WNDDVCQRPY-RWVCETELDKASQEPPLL

ASGPR-H2                  SWKWVDGTDYRHNYK-------NWAVTQPDNWHGHELGGSEDCVEVQ-PDGR-----WNDDFCLQVY-RWVCEKRRNATGEVA

ASGPR-M                   AWKWVDGTDYATGFQ-------NWKPGQPDDWQGHGLGGGEDCAHFH-PDGR-----WNDDVCQRPY-HWVCEAGLGQTSQESH

DCIR                      HWQWVDQTPYNESST-------FWHPREPSD-------PNERCVVLN-FRKSPKRWGWNDVNCLGPQ-RSVCEMMKIHL

Dectin-2                  NWQWIDKTPYEKNVR-------FWHLGEPN-------HSAEQCASIV-FWKPT-GWGWNDVICETRR-NSICEMNKIYL

Mincle                    QWQWVDGTPLTKSLS-------FWDVGEPNN-----IATLEDCATMR-DSSNP-RQNWNDVTCFLNY-FRICEMVGINPLNKGKSL

BDCA-2                    HWQWVDQTPYNENVT-------FWHSGEPNN-------LDERCAIIN-FRSSE-EWGWNDIHCHVPQ-KSICKMKKIYI

CLEC-6                    QWRWVDQTPFNPRRV-------FWHKNEPDN------SQGENCVVLV-YNQD--KWAWNDVPCNFEA-SRICKIPGTTLN

SRCL                      EWKWLDGTSPDYK---------NWKAGQPDNW-GHGHGPGEDCAGLI-YAGQ-----WNDFQCEDVN-NFICEKDRETVLSSAL

Langerin                  DWSWVDDTPFNKVQSAR-----FWIPGEPNN-----AGNNEHCGNIK-APSLQA---WNDAPCDKTF-LFICKRPYVPSEP

Kupffer                   SWRWTDGTPFNAAQNKAPVVFGFWEKNQSDNWR-HKNGQTEDCVQIQ-QK-------WNDMTCDTPY-QWVCKK

 

CONSERVED CORE RESIDUES     Ca SITE 1 LIGANDS     Ca SITE 2 LIGANDS (SUGAR-BINDING SITE)

 

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This page last updated:	Wednesday, 01 January 2014	Animal lectins home
Contact information:	This site is supported by:
Kurt Drickamer Division of Molecular Biosciences Faculty of Natural Sciences Imperial College London   Email: k.drickamer@imperial.ac.uk