Group XIII - IDD
IDD (integral membrane protein, deleted in DiGeorge syndrome) is a unique CTLD-containing type 1 transmembrane protein expressed in a range of cell types and notably in the developing nervous system. The extracellular region consists of a CTLD sandwiched between a membrane-distal low density lipoprotein (LDL)-receptor class A domain and a membrane-proximal von Willebrand Factor C domain. IDD also has a sizeable intracellular region.
IDD may function as an adhesion receptor in cell-cell or cell-matrix interactions during cell differentiation and migration, particularly in the nervous system, or may be involved in signalling. The IDD gene lies within the DiGeorge syndrome critical region – the minimal region of chromosome 22 which when deleted gives rise to this condition. However, it is not known if IDD has a role in the aetiology of DiGeorge syndrome, or of other ‘CATCH 22’ developmental defects associated with deletions in this region of chromosome 22.
The CTLD in IDD is not known to have sugar-binding activity.
