TY - UNPB AB - Rationale: The impact of COVID-19 on patients with Interstitial Lung Disease (ILD) has not been established. Objectives: To assess outcomes following COVID-19 in patients with ILD versus those without in a contemporaneous age, sex and comorbidity matched population. Methods: An international multicentre audit of patients with a prior diagnosis of ILD admitted to hospital with COVID-19 between 1 March and 1 May 2020 was undertaken and compared with patients, without ILD obtained from the ISARIC 4C cohort, admitted with COVID-19 over the same period. The primary outcome was survival. Secondary analysis distinguished IPF from non-IPF ILD and used lung function to determine the greatest risks of death. Measurements and Main Results: Data from 349 patients with ILD across Europe were included, of whom 161 were admitted to hospital with laboratory or clinical evidence of COVID-19 and eligible for propensity-score matching. Overall mortality was 49% (79/161) in patients with ILD with COVID-19. After matching ILD patients with COVID-19 had higher mortality (HR 1.60, Confidence Intervals 1.17-2.18 p=0.003) compared with age, sex and co-morbidity matched controls without ILD. Patients with a Forced Vital Capacity (FVC) of <80% had an increased risk of death versus patients with FVC ≥80% (HR 1.72, 1.05-2.83). Furthermore, obese patients with ILD had an elevated risk of death (HR 1.98, 1.13−3.46). Conclusions: Patients with ILD are at increased risk of death from COVID-19, particularly those with poor lung function and obesity. Stringent precautions should be taken to avoid COVID-19 in patients with ILD. AU - Drake,TM AU - Docherty,AB AU - Harrison,EM AU - Quint,JK AU - Adamali,H AU - Agnew,S AU - Babu,S AU - Barber,CM AU - Barratt,S AU - Bendstrup,E AU - Bianchi,S AU - Villegas,DC AU - Chaudhuri,N AU - Chua,F AU - Coker,R AU - Chang,W AU - Crawshaw,A AU - Crowley,LE AU - Dosanjh,D AU - Fiddler,CA AU - Forrest,IA AU - George,P AU - Gibbons,MA AU - Groom,K AU - Haney,S AU - Hart,SP AU - Heiden,E AU - Henry,M AU - Ho,L-P AU - Hoyles,RK AU - Hutchinson,J AU - Hurley,K AU - Jones,M AU - Jones,S AU - Kokosi,M AU - Kreuter,M AU - MacKay,L AU - Mahendran,S AU - Margaritopoulos,G AU - Molina-Molina,M AU - Molyneaux,PL AU - OBrien,A AU - OReilly,K AU - Packham,A AU - Parfrey,H AU - Poletti,V AU - Porter,J AU - Renzoni,E AU - Rivera-Ortega,P AU - Russell,A-M AU - Saini,G AU - Spencer,LG AU - Stella,GM AU - Stone,H AU - Sturney,S AU - Thickett,D AU - Thillai,M AU - Wallis,T AU - Ward,K AU - Wells,AU AU - West,A AU - Wickremasinghe,M AU - Woodhead,F AU - Hearson,G AU - Howard,L AU - Baillie,JK AU - Openshaw,PJM AU - Semple,MG AU - Stewart,I AU - ISARIC4C,Investigators AU - Jenkins,RG DO - 10.1101/2020.07.15.20152967 PB - bioRxiv PY - 2020/// TI - Outcome of hospitalisation for COVID-19 in patients with interstitial lung disease: an international multicentre study. UR - http://dx.doi.org/10.1101/2020.07.15.20152967 UR - https://www.medrxiv.org/content/10.1101/2020.07.15.20152967v1 UR - http://hdl.handle.net/10044/1/81952 ER -