TY - JOUR AB - Motivation: The field of toxicogenomics (the application of ‘-omics’ technologies to risk assessment of compound toxicities) has expanded in the last decade, partly driven by new legislation, aimed at reducing animal testing in chemical risk assessment but mainly as a result of a paradigm change in toxicology towards the use and integration of genome wide data. Many research groups worldwide have generated large amounts of such toxicogenomics data. However, there is no centralized repository for archiving and making these data and associated tools for their analysis easily available.Results: The Data Infrastructure for Chemical Safety Assessment (diXa) is a robust and sustainable infrastructure storing toxicogenomics data. A central data warehouse is connected to a portal with links to chemical information and molecular and phenotype data. diXa is publicly available through a user-friendly web interface. New data can be readily deposited into diXa using guidelines and templates available online. Analysis descriptions and tools for interrogating the data are available via the diXa portal.Availability and implementation:http://www.dixa-fp7.euContact:d.hendrickx@maastrichtuniversity.nl; info@dixa-fp7.euSupplementary information:Supplementary data are available at Bioinformatics online. AU - Hendrickx,DM AU - Aerts,HJWL AU - Caiment,F AU - Clark,D AU - Ebbels,TMD AU - Evelo,CT AU - Gmuender,H AU - Hebels,DGAJ AU - Herwig,R AU - Hescheler,J AU - Jennen,DGJ AU - Jetten,MJA AU - Kanterakis,S AU - Keun,HC AU - Matser,V AU - Overington,JP AU - Pilicheva,E AU - Sarkans,U AU - Segura-Lepe,MP AU - Sotiriadou,I AU - Wittenberger,T AU - Wittwehr,C AU - Zanzi,A AU - Kleinjans,JCS DO - bioinformatics/btu827 EP - 1507 PY - 2015/// SN - 1367-4803 SP - 1505 TI - diXa: a data infrastructure for chemical safety assessment T2 - Bioinformatics UR - http://dx.doi.org/10.1093/bioinformatics/btu827 UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000355665800031&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202 UR - https://academic.oup.com/bioinformatics/article/31/9/1505/200092 UR - http://hdl.handle.net/10044/1/93305 VL - 31 ER -