TY - JOUR AB - T cell receptor interactions with peptide/major histocompatibility complex (pMHC) ligandscontrol the selection of T cells in the thymus as well as their homeostasis in peripheral lymphoidorgans. Here we show that pMHC contact modulates the expression of CD5 by naiveCD4 T cells in a process that requires the continued expression of p56lck. Reduced CD5 levelsin T cells deprived of pMHC contact are predictive of elevated Ca2 responses to subsequentTCR engagement by anti-CD3 or nominal antigen. Adaptation to peripheral pMHC contactmay be important for regulating naive CD4 T cell responsiveness. AU - Smith,K AU - Seddon,B AU - Purbhoo,MA AU - Zamoyska,R AU - Fisher,AG AU - Merkenslchlager,M DO - 10.1084/jem.194.9.1253 EP - 1261 PY - 2001/// SN - 1540-9538 SP - 1253 TI - Sensory adaptation in naive peripheral CD4 T cells T2 - Journal of Experimental Medicine UR - http://dx.doi.org/10.1084/jem.194.9.1253 UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000172159500007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202 UR - http://hdl.handle.net/10044/1/31081 VL - 194 ER -