TY - JOUR AB - BackgroundPrevious studies have reported national and regional Global Burden of Disease (GBD) estimates for the UK. Because of substantial variation in health within the UK, action to improve it requires comparable estimates of disease burden and risks at country and local levels. The slowdown in the rate of improvement in life expectancy requires further investigation. We use GBD 2016 data on mortality, causes of death, and disability to analyse the burden of disease in the countries of the UK and within local authorities in England by deprivation quintile.MethodsWe extracted data from the GBD 2016 to estimate years of life lost (YLLs), years lived with disability (YLDs), disability-adjusted life-years (DALYs), and attributable risks from 1990 to 2016 for England, Scotland, Wales, Northern Ireland, the UK, and 150 English Upper-Tier Local Authorities. We estimated the burden of disease by cause of death, condition, year, and sex. We analysed the association between burden of disease and socioeconomic deprivation using the Index of Multiple Deprivation. We present results for all 264 GBD causes of death combined and the leading 20 specific causes, and all 84 GBD risks or risk clusters combined and 17 specific risks or risk clusters.FindingsThe leading causes of age-adjusted YLLs in all UK countries in 2016 were ischaemic heart disease, lung cancers, cerebrovascular disease, and chronic obstructive pulmonary disease. Age-standardised rates of YLLs for all causes varied by two times between local areas in England according to levels of socioeconomic deprivation (from 14274 per 100000 population [95% uncertainty interval 12791–15875] in Blackpool to 6888 [6145–7739] in Wokingham). Some Upper-Tier Local Authorities, particularly those in London, did better than expected for their level of deprivation. Allowing for differences in age structure, more deprived Upper-Tier Local Authorities had higher attributable YLLs for most major risk factors in the GBD. AU - Steel,N AU - Ford,JA AU - Newton,JN AU - Davis,ACJ AU - Vos,T AU - Naghavi,M AU - Glenn,S AU - Hughes,A AU - Dalton,AM AU - Stockton,D AU - Humphreys,C AU - Dallat,M AU - Schmidt,J AU - Flowers,J AU - Fox,S AU - Abubakar,I AU - Aldridge,RW AU - Baker,A AU - Brayne,C AU - Brugha,T AU - Capewell,S AU - Car,J AU - Cooper,C AU - Ezzati,M AU - Fitzpatrick,J AU - Greaves,F AU - Hay,R AU - Hay,S AU - Kee,F AU - Larson,HJ AU - Lyons,RA AU - Majeed,A AU - McKee,M AU - Rawaf,S AU - Rutter,H AU - Saxena,S AU - Sheikh,A AU - Smeeth,L AU - Viner,RM AU - Vollset,SE AU - Williams,HC AU - Wolfe,C AU - Woolf,A AU - Murray,CJL DO - 10.1016/S0140-6736(18)32207-4 EP - 1661 PY - 2018/// SN - 0140-6736 SP - 1647 TI - Changes in health in the countries of the UK and 150 English Local Authority areas 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 T2 - The Lancet UR - http://dx.doi.org/10.1016/S0140-6736(18)32207-4 UR - http://hdl.handle.net/10044/1/64093 VL - 392 ER -