TY - JOUR AB - Bacterial infections of the pulmonary system are increasing. With almost half of today's infections beingcaused by strains of bacteria that are resistant to existing conventional antibiotics, there is an urgent needfor the development of novel therapeutic platforms. Silver nanoparticles (AgNPs) have been receivingincreasing attention due to their unique antibacterial properties, and whilst the biological efficacy of silveris well known, the mechanisms by which AgNPs degrade within cells and how these processes correlate totheir bioreactivity are poorly understood. This review summarises the current knowledge on thebactericidal pathways of AgNPs and discusses the challenges to be faced before we are able to developefficient and safe antibacterial agents for the treatment of bacterial infections in the lung. AU - Theodorou,I AU - Porter,AE AU - Ryan,M AU - leo,BF AU - López-Heras,M DO - 10.1039/C5EN00051C EP - 326 PY - 2015/// SN - 2051-8161 SP - 312 TI - Towards understanding the antibacterial activity of Ag nanoparticles: electron microscopy in the analysis of the materials-biology interface in the lung T2 - Environmental Science: Nano UR - http://dx.doi.org/10.1039/C5EN00051C UR - http://hdl.handle.net/10044/1/25009 VL - 2 ER -