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• Journal article
  Massey LA, Micallef C, Paviour DC, O'Sullivan SS, Ling H, Williams DR, Kallis C, Holton JL, Revesz T, Burn DJ, Yousry T, Lees AJ, Fox NC, Jaeger HRet al., 2012,

  Conventional Magnetic Resonance Imaging in Confirmed Progressive Supranuclear Palsy and Multiple System Atrophy

  , MOVEMENT DISORDERS, Vol: 27, Pages: 1755-1762, ISSN: 0885-3185
  • Author Web Link
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  • Citations: 133
• Journal article
  Windsor RE, Strauss SJ, Kallis C, Wood NE, Whelan JSet al., 2012,

  Germline Genetic Polymorphisms May Influence Chemotherapy Response and Disease Outcome in Osteosarcoma

  , CANCER, Vol: 118, Pages: 1856-1867, ISSN: 0008-543X
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  • Citations: 105
• Journal article
  Gregoire SM, Smith K, Jaeger HR, Benjamin M, Kallis C, Brown MM, Cipolotti L, Werring DJet al., 2012,

  Cerebral Microbleeds and Long-Term Cognitive Outcome: Longitudinal Cohort Study of Stroke Clinic Patients

  , CEREBROVASCULAR DISEASES, Vol: 33, Pages: 430-435, ISSN: 1015-9770
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  • Citations: 58
• Journal article
  Thillai M, Eberhardt C, Lewin AM, Potiphar L, Hingley-Wilson S, Sridhar S, Macintyre J, Kon OM, Wickremasinghe M, Wells A, Weeks ME, Mitchell D, Lalvani Aet al., 2012,

  Sarcoidosis and tuberculosis cytokine profiles: indistinguishable in bronchoalveolar lavage but different in blood

  , PLoS One, Vol: 7, ISSN: 1932-6203

  BACKGROUND: The clinical, radiological and pathological similarities between sarcoidosis and tuberculosis can make disease differentiation challenging. A complicating factor is that some cases of sarcoidosis may be initiated by mycobacteria. We hypothesised that immunological profiling might provide insight into a possible relationship between the diseases or allow us to distinguish between them. METHODS: We analysed bronchoalveolar lavage (BAL) fluid in sarcoidosis (n = 18), tuberculosis (n = 12) and healthy volunteers (n = 16). We further investigated serum samples in the same groups; sarcoidosis (n = 40), tuberculosis (n = 15) and healthy volunteers (n = 40). A cross-sectional analysis of multiple cytokine profiles was performed and data used to discriminate between samples. RESULTS: We found that BAL profiles were indistinguishable between both diseases and significantly different from healthy volunteers. In sera, tuberculosis patients had significantly lower levels of the Th2 cytokine interleukin-4 (IL-4) than those with sarcoidosis (p = 0.004). Additional serum differences allowed us to create a linear regression model for disease differentiation (within-sample accuracy 91%, cross-validation accuracy 73%). CONCLUSIONS: These data warrant replication in independent cohorts to further develop and validate a serum cytokine signature that may be able to distinguish sarcoidosis from tuberculosis. Systemic Th2 cytokine differences between sarcoidosis and tuberculosis may also underly different disease outcomes to similar respiratory stimuli.

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• Journal article
  Sharma S, Bandopadhyay R, Lashley T, Renton AEM, Kingsbury AE, Kumaran R, Kallis C, Vilarino-Gueell C, O'Sullivan SS, Lees AJ, Revesz T, Wood NW, Holton JLet al., 2011,

  LRRK2 expression in idiopathic and G2019S positive Parkinson's disease subjects: a morphological and quantitative study

  , NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol: 37, Pages: 777-790, ISSN: 0305-1846
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  • Citations: 35
• Journal article
  Parkkinen L, O'Sullivan SS, Kuoppamaki M, Collins C, Kallis C, Holton JL, Williams DR, Revesz T, Lees AJet al., 2011,

  Does levodopa accelerate the pathologic process in Parkinson disease brain?

  , NEUROLOGY, Vol: 77, Pages: 1420-1426, ISSN: 0028-3878
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  • Citations: 51
• Journal article
  Clayton LM, Devile M, Punte T, Kallis C, de Haan G-J, Sander JW, Acheson J, Sisodiya SMet al., 2011,

  Retinal Nerve Fiber Layer Thickness in Vigabatrin-Exposed Patients

  , ANNALS OF NEUROLOGY, Vol: 69, Pages: 845-854, ISSN: 0364-5134
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  • Citations: 38
• Journal article
  Compta Y, Parkkinen L, O'Sullivan SS, Vandrovcova J, Holton JL, Collins C, Lashley T, Kallis C, Williams DR, de Silva R, Lees AJ, Revesz Tet al., 2011,

  Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important?

  , BRAIN, Vol: 134, Pages: 1493-1505, ISSN: 0006-8950
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  • Citations: 402
• Journal article
  Flouri E, Kallis C, 2011,

  Adverse life events and mental health in middle adolescence

  , JOURNAL OF ADOLESCENCE, Vol: 34, Pages: 371-377, ISSN: 0140-1971
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  • Citations: 15
• Journal article
  Jenkins T, Toosy AT, Ciccarelli O, Miszkiel KA, Wheeler-Kingshott CA, Henderson AP, Kallis C, Mancini L, Plant GT, Miller DH, Thompson AJet al., 2010,

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  , Annals of Neurology, Vol: 68, ISSN: 0364-5134
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